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Plasma 25-hydroxyvi...
Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition : A nested case-control study
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Kühn, Tilman (author)
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Kaaks, Rudolf (author)
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Becker, Susen (author)
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show more...
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Eomois, Piia-Piret (author)
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Clavel-Chapelon, Françoise (author)
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Kvaskoff, Marina (author)
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Dossus, Laure (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Overvad, Kim (author)
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Chang-Claude, Jenny (author)
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Lukanova, Annekatrin (author)
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Buijsse, Brian (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Bamia, Christina (author)
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Masala, Giovanna (author)
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Krogh, Vittorio (author)
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Sacerdote, Carlotta (author)
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Tumino, Rosario (author)
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Mattiello, Amalia (author)
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Buckland, Genevieve (author)
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Sánchez, María-José (author)
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Menéndez, Virginia (author)
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Chirlaque, María-Dolores (author)
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Barricarte, Aurelio (author)
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Bueno-de-Mesquita, H Bas (author)
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van Duijnhoven, Fränzel J B (author)
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van Gils, Carla H (author)
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Bakker, Marije F (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Skeie, Guri (author)
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Brustad, Magritt (author)
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- Andersson, Anne (author)
- Umeå universitet,Onkologi
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi
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Wareham, Nick (author)
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Khaw, Kay Tee (author)
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Travis, Ruth C (author)
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Schmidt, Julie A (author)
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Rinaldi, Sabina (author)
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Romieu, Isabelle (author)
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Gallo, Valentina (author)
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Murphy, Neil (author)
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Riboli, Elio (author)
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Linseisen, Jakob (author)
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(creator_code:org_t)
- 2013-04-22
- 2013
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 133:7, s. 1689-1700
- Related links:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case-control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case-control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) was carried out comprising 1,391 incident breast cancer cases and 1,391 controls. Multivariable conditional logistic regression models did not reveal a significant overall association between season-standardized 25(OH)D levels and the risk of breast cancer (ORQ4-Q1 [95% CI]: 1.07 [0.85-1.36], ptrend = 0.67). Moreover, 25(OH)D levels were not related to the risks of estrogen receptor positive tumors (ORQ4-Q1 [95% CI]: 0.97 [0.67-1.38], ptrend = 0.90) and estrogen receptor negative tumors (ORQ4-Q1 [95% CI]: 0.97 [0.66-1.42], ptrend = 0.98). In hormone replacement therapy (HRT) users, 25(OH)D was significantly inversely associated with incident breast cancer (ORlog2 [95% CI]: 0.62 [0.42-0.90], p = 0.01), whereas no significant association was found in HRT nonusers (ORlog2 [95% CI]: 1.14 [0.80-1.62], p = 0.48). Further, a nonsignificant inverse association was found in women with body mass indices (BMI) < 25 kg/m(2) (ORlog2 [95% CI]: 0.83 [0.67-1.03], p = 0.09), as opposed to a borderline significant positive association in women with BMI ≥ 25 kg/m(2) (ORlog2 [95% CI]: 1.30 [1.0-1.69], p = 0.05). Overall, prediagnostic levels of circulating 25(OH)D were not related to the risk of breast cancer in the EPIC study. This result is in line with findings in the majority of prospective studies and does not support a role of vitamin D in the development of breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kühn, Tilman
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Kaaks, Rudolf
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Becker, Susen
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Eomois, Piia-Pir ...
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Clavel-Chapelon, ...
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Kvaskoff, Marina
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show more...
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Dossus, Laure
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Kim
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Chang-Claude, Je ...
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Lukanova, Anneka ...
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Buijsse, Brian
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Boeing, Heiner
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Trichopoulou, An ...
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Lagiou, Pagona
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Bamia, Christina
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Masala, Giovanna
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Krogh, Vittorio
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Sacerdote, Carlo ...
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Tumino, Rosario
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Mattiello, Amali ...
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Buckland, Genevi ...
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Sánchez, María-J ...
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Menéndez, Virgin ...
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Chirlaque, María ...
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Barricarte, Aure ...
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Bueno-de-Mesquit ...
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van Duijnhoven, ...
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van Gils, Carla ...
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Bakker, Marije F
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Weiderpass, Elis ...
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Skeie, Guri
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Brustad, Magritt
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Andersson, Anne
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Sund, Malin, 197 ...
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Wareham, Nick
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Khaw, Kay Tee
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Travis, Ruth C
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Schmidt, Julie A
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Rinaldi, Sabina
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Romieu, Isabelle
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Gallo, Valentina
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Murphy, Neil
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Riboli, Elio
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Linseisen, Jakob
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet