| 1. |
- Chang, E. T., et al.
(författare)
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Re : Zinc supplement use and risk of prostate cancer (multiple letters) [1]
- 2004
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Ingår i: Journal of the National Cancer Institute. - Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden. Umea Univ, Dept Radiat Sci Oncol, Umea, Sweden. : OXFORD UNIV PRESS INC. - 0027-8874 .- 1460-2105. ; 96:14, s. 1108-1109
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Lindmark, F, et al.
(författare)
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H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer
- 2004
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Ingår i: Journal of the National Cancer Institute. - Umea Univ, Dept Radiat Sci Oncol, S-90187 Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Umea Univ Hosp, Dept Urol & Androl, S-90185 Umea, Sweden. Wake Forest Univ, Sch Med, Ctr Human Genomics, Winston Salem, NC 27109 USA. Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA. : OXFORD UNIV PRESS INC. - 0027-8874 .- 1460-2105. ; 96:16, s. 1248-1254
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Tidskriftsartikel (refereegranskat)abstract
- Background: Accumulating epidemiologic and molecular evidence suggest that inflammation is an important component in the etiology of prostate cancer. Macrophage-inhibitory cytokine-1 (MIC-1), a member of the transforming growth factor beta superfamily, is thought to play an important role in inflammation by regulating macrophage activity. We examined whether sequence variants in the MIC-1 gene are associated with the risk of prostate cancer. Methods: The study population, a population-based case-control study in Sweden, consisted of 1383 prostate cancer case patients and 780 control subjects. From 94 of the control subjects, we constructed gene-specific haplotypes of MIC-1 and identified four haplotype-tagging single-nucleotide polymorphisms (SNPs): Exon1+25 (V9L), Exon1+142 (S48T), IVS1+1809, and Exon2+2423 (H6D). All study subjects were genotyped for the four SNPs, and conditional logistic regression analysis was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Results: A statistically significant difference (P = .006) in genotype frequency was observed for the nonsynonymous change H6D) (histidine to aspartic acid at position 6) between prostate cancer patients and control subjects. Carriers of the GC genotype, which results in the H6D change, experienced a lower risk of sporadic prostate cancer (OR = 0.80, 95% CI = 0.66 to 0.97) and of familial prostate cancer (OR = 0.61, 95% CI = 0.42 to 0.89) than the CC genotype carriers. In the study population, the proportion of prostate cancer cases attributable to the CC genotype was 7.2% for sporadic cancer and 19.2% for familial cancer. None of the other SNPs or haplotypes was associated with prostate cancer. Conclusion: This study shows an association between a nonsynonymous change (H6D) in the MIC-1 gene and prostate cancer. This finding supports the hypothesis that genetic variation in the inflammatory process contributes to prostate cancer susceptibility.
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| 3. |
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| 4. |
- Lundgren, Berit, 1951-
(författare)
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Att som vuxen bli litterat på sitt andraspråk
- 2002. - 1
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Ingår i: Forskning i nordiske sprog som andet- og fremmedsprog. - Reykjavík : Háskóli Íslands. - 9979545402 ; , s. 295-314
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Lundgren, Berit, 1951-
(författare)
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"Jag har tio barn så jag behöver inte bekymra mig om min ålderdom" : om skolans möjligheter att skapa förståelse
- 2004. - 1
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Ingår i: Andra nationella konferensen i svenska med didaktisk inriktning. - Göteborg : Göteborgs universitet. - 9197472212 ; , s. 123-139
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Skolan har ett stort och viktigt ansvar för att utveckla kunskaper i det svenska språket för människor som kommer till Sverige från andra länder. I kapitlet beskrivs, utifrån ett sociokulturellt perspektiv, hur några kvinnor som är analfabeter lär sig det svenska språket samt lär sig läsa och skriva på svenska inom svenskundervisning för invandrare. Studien som har sitt ursprung i avhandlingen Skolan i livet - Livet i skolan visar att kommunikation vanligtvis bygger på I-R-U mönster men att kollaborativa samtal förekommer. Det som också framkommer är att deltagarnas erfrenheter inte tas tillvara i undersvisningssituationer i någon större utsträckning. Det medför i sin tur att deltagarna känner sig okunniga.
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| 6. |
- Sjöberg, R L, et al.
(författare)
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Decision-making and euthanasia
- 2003
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Ingår i: British Journal of Psychiatry. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 182:2, s. 171-173
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Sjöberg, Rickard L, et al.
(författare)
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Gender biases in decisions on euthanasia among Swedish jurors
- 2003
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Ingår i: Nordic Journal of Psychiatry. - : Informa UK Limited. - 0803-9488 .- 1502-4725. ; 57:6, s. 469-471
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Tidskriftsartikel (refereegranskat)abstract
- The present study set out to investigate whether group- based biases may influence decisions regarding euthanasia in Swedish jurors ( namndeman). Thirty- eight Swedish jurors were presented with a case description of euthanasia in a severely brain- damaged patient. Age and gender of the patient were systematically varied. The jurors were asked to what extent they believed that euthanasia was ethical in the case presented to them and whether they thought that it should be legal. Jurors tended to be supportive of euthanasia and were more so when it was used on patients who belonged to the opposite gender. These results suggest that group- based biases may influence decisions regarding euthanasia in Swedish jurors. The finding has implication for the Swedish debate regarding a possible legalization of such procedures.
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