| 1. |
- Widenheim, Jan, 1930-, et al.
(författare)
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Förebyggande tandvård
- 1997. - 1
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Bok (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Brånemark, Rickard, 1960, et al.
(författare)
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Biomechanical characterization of osseointegration during healing: an experimental in vivo study in the rat.
- 1997
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Ingår i: Biomaterials. - 0142-9612. ; 18:14, s. 969-78
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Tidskriftsartikel (refereegranskat)abstract
- This study reports torsion tests and pull-out tests on osseointegrated commercially pure titanium fixtures. The tests were performed in vivo on a total of 26 rats. Three fixtures with a diameter of 2.0 mm were installed bilaterally in the proximal tibia in each animal. The mechanical testing was performed immediately after installation, after 2, 4, 8 and 16 weeks of unloaded healing. The torsional strength started to increase after 4 weeks of unloaded healing and there was a significant increase with time during the initial 16 weeks. The pull-out load increased rapidly during the first 4 weeks; thereafter, a moderate increase occurred during the following 12 weeks. A histological evaluation was performed after 0, 4, 8 and 16 weeks. There were significant (P < 0.01) correlations between torque and percentage of bone in contact with the fixture, and between pull-out load and the bone thickness around the fixture (P < 0.001). Estimations of shear stresses and shear moduli in the bone tissue (pull-out test) and at the interface (torque test) indicated that the increase in bone volume around the implant substantially improved the mechanical capacity.
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| 3. |
- Flygare, Lennart, et al.
(författare)
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Cartilage matrix macromolecules in lavage fluid of temporomandibular joints before and 6 months after diskectomy
- 1997
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Ingår i: European Journal of Oral Sciences. - : Wiley-Blackwell. - 0909-8836 .- 1600-0722. ; 105:4, s. 369-372
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Tidskriftsartikel (refereegranskat)abstract
- The purpose was to investigate if antigenic fragments of aggrecan and cartilage oligomeric matrix protein (COMP) are detectable by enzyme-linked immunosorbent assay in lavage fluids from the temporomandibular joint (TMJ) and to examine if the relative content of these cartilage markers changes during development of osteoarthrosis (OA) after diskectomy. Lavage fluid was obtained at surgery and 6 months postoperatively in 13 patients. Computed tomography or magnetic resonance imaging was without evidence of hard-tissue changes prior to surgery in all patients. In 9 of the patients, sufficient material for analysis was obtained at both examinations. Aggrecan and COMP were detectable in all but 2 fluids, in which the COMP levels were below detection limit. The aggrecan/COMP ratio increased in all 9 patients during the 6-month period, indicating increased release of aggrecan relative to COMP fragments. The changed aggrecan/COMP ratio possibly reflects increased cartilage turnover during development of OA. Changes compatible with OA were present on computed tomography in all cases at the 6-month follow-up. This study shows that the lavage procedure is feasible for obtaining synovial fluid from the TMJ for immunochemical analyses of tissue-derived macromolecules.
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| 4. |
- Flygare, Lennart, et al.
(författare)
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Chronic recurrent multifocal osteomyelitis involving both jaws : report of a case including magnetic resonance correlation
- 1997
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Ingår i: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. - : Elsevier. - 1079-2104 .- 1528-395X. ; 83:2, s. 300-305
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Tidskriftsartikel (refereegranskat)abstract
- A case of chronic recurrent multifocal osteomyelitis in a 14-year-old girl is presented. The disease had an initial aggressive osteolytic appearance involving both the maxilla and the mandible. Conservative treatment with minimal surgical intervention has been successful in this case during a 2-year follow-up period. The value of magnetic resonance imaging and bone scintigraphy in this case and the cause of chronic recurrent multifocal osteomyelitis is discussed.
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| 5. |
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| 6. |
- Ekestubbe, Annika, 1953, et al.
(författare)
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The use of tomography for dental implant planning.
- 1997
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Ingår i: Dento maxillo facial radiology. - : British Institute of Radiology. - 0250-832X. ; 26:4, s. 206-13
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To examine the use of tomography for dental implant planning. METHODS: A questionnaire was sent to oral radiology clinics in Sweden and to implantology clinics in different parts of the world with questions on selection criteria and techniques for, and frequency of, pre-implant tomography. Differences between mean values were assessed by t-test. A new method developed by the Swedish Radiation Protection Institute was used to assess radiation absorbed dose from CT. RESULTS: Tomography was used by 93.4% of the clinics, but there was marked variation both between and within different clinical situations. It was performed in all cases by 21% and the majority used it for the evaluation of the maxilla, the posterior mandible and in single implant cases. Small clinics (< 100 patients per year) used tomography frequently and clinics in Sweden significantly more often than those in other countries. The majority had changed their policy recently, using tomography more often. CT was used by 73% of respondents, mainly the small clinics. The majority of the large clinics (> 500 patients per year) used conventional tomography. The mean absorbed dose for CT scanning protocols was 65 mGy. The variation within and between different makes of CT was considerable. CONCLUSIONS: There are large variations in frequency of use of both conventional and computed tomography for dental implant planning by different clinics who also vary in the indications for their choice. A substantial factor influencing the technique chosen was its availability rather than clinical need.
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| 7. |
- Flygare, Lennart, et al.
(författare)
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Bone histomorphometry using interactive image analysis. A methodological study with application on the human temporomandibular joint.
- 1997
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Ingår i: European Journal of Oral Sciences. - : Wiley-Blackwell. - 0909-8836 .- 1600-0722. ; 105:1, s. 67-73
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to develop a reproducible method for bone histomorphometry with the aid of a computerized image analysis program, and to examine the variation when assessing the total and the trabecular bone volume. Histologic sections of 18 temporomandibular joint autopsy specimens were read interactively using a cursor. The two parameters total bone volume and trabecular bone volume, of the condyle and the temporal component respectively, were estimated 2 x by 1 observer using 3 different threshold settings: an automatic, a semi-automatic and a manual technique. The threshold was based on the gray-scale distribution of the image. 2 observers read the same sections with the aid of the semi-automatic technique. The intra-observer variation expressed as coefficient of variation ranged between 1.9% and 7.1% for the different parameters, when the automatic threshold setting technique was employed, and between 2.8% and 8.7% with the semi-automatic technique. The manual technique resulted in a high intra-observer variation with a coefficient of variation between 5.2% and 19.9%. There was a systematic difference between the estimates of the 2 observers. In general, intra- and inter-observer variation was higher in the temporal component than in the condyle. The inter-section variation was moderate, the coefficient of variation ranging from 3.8% to 11.1%. The automatic and semi-automatic techniques resulted in comparable intra-observer variation, with a lower bias in the estimates of the semi-automatic technique. By letting one observer apply the semi-automatic technique, it was possible to achieve fast and reproducible analysis of the total and trabecular bone volume.
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| 8. |
- Flygare, Lennart, et al.
(författare)
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Bone volume in human temporomandibular autopsy joints with and without erosive changes
- 1997
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Ingår i: Acta Odontologica Scandinavica. - : Informa Healthcare. - 0001-6357 .- 1502-3850. ; 55:3, s. 167-172
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to compare the trabecular bone volume (TBV) and the total bone volume (TOBV) of human temporomandibular joints (TMJ) with erosive changes with those of joints without erosive changes. We examined 35 TMJ autopsy specimens from 19 individuals aged 66 88 years. Sagittal sections of the joints were analyzed microscopically for erosive hard-tissue changes. The TBV and the TOBV of the sections were assessed with the aid of computerized image analysis. A significant increase in trabecular and total bone volume was found in condyles with erosive changes (TBV = 21%, TOBV = 54%) as compared with condyles without erosive changes (TBV = 15%, TOBV = 40%). The trabecular bone volume of the temporal component was also increased (TBV = 24%) in joints with erosive changes in the condyle as compared with joints with unaffected condyles (TBV = 16%). The findings indicate that the relative bone mass may play a role in the development of erosive changes in the TMJ.
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| 9. |
- Flygare, Lennart, 1961-
(författare)
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Degenerative changes of the human temporomandibular joint : A radiological, microscopical, histomorphometrical and biochemical study
- 1997
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In five autopsy specimen studies human temporomandibular joints were investigated by conventional tomography, macroscopy, and microscopy for degenerative changes, in particular erosive hard-tissue changes.In the microscopical evaluation special attention was paid to the calcified cartilage. The calcified cartilage was outlined by a flat or gently undulating basophilic tidemark and an irregular osteochondral junction. A significant correlation was found between the thickness of the calcified cartilage and that of the total articular cartilage. Two types of erosive changes were found; an extensive type with complete loss of overlying cartilage and a local type with retained cartilage. The erosive changes were generally more extensive in the condyle. Microscopically, the erosive changes in the condyle were evenly distributed. In the temporal component there was a slight predominance of these changes located to the lateral part of the tubercle. Tomography underestimated both the presence and the extent of the erosive changes. Positive predictive values and negative predictive values were 0.70 and 0.83, respectively, for changes in the condyle and 0.91 and 0.68 for changes in the temporal component. The likelihood ratio for a positive test was 10.6 in the temporal component and 5.6 in the condyle. The likelihood ratio for a negative test was comparable in the two joint components 0.49 and 0.47 respectively. Three different techniques of computer-aided bone histomorphometry (manual, automatic and semi-automatic) were assessed. The variation when assessing the total and trabecular bone volume was evaluated. Good reproducibility in the assessment of the total and trabecular bone volume was achieved with the aid of a single observer and a semi-automatic technique. This technique was therefore used to assess the total and trabecular bone volume in condyles and temporal components of joints with and without microscopically verified erosive changes. Condyles with erosive changes demonstrated both a higher trabecular bone volume (P< 0.05) and higher total bone volume (P< 0.01) than condyles without erosive changes. In a clinical study on patients undergoing diskectomy, the two cartilage matrix macromolecules aggrecan and cartilage oligomeric matrix protein (COMP) were quantified by enzyme-linked immunosorbent assay in lavage fluids from temporomandibular joints before and six months after surgery. The aggrecan/COMP ratio was higher in the lavage fluid of all joints at follow-up as compared to preoperatively. All joints developed radiographic changes indicative of degenerative changes (osteoarthrosis) during the postoperative period.
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| 10. |
- Friberg, Bertil, 1950, et al.
(författare)
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Mk II: the self-tapping Brånemark implant: 5-year results of a prospective 3-center study.
- 1997
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Ingår i: Clinical oral implants research. - 0905-7161. ; 8:4, s. 279-85
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Tidskriftsartikel (refereegranskat)abstract
- The 5-year result of a prospective 3-center study is presented, comprising 103 patients with 288 Mk II self-tapping and 275 standard implants of the Brånemark System. Out of 363 mandibular and 200 maxillary fixtures, one Mk II was lost of the lower jaw and 13 of each implant type failed in maxillae during the study period. Cumulative prosthesis stability was 97%. Five patients accounted for more than 85% of the fixture losses. Marginal bone resorption was similar for both implant designs. Apart from the implant failures and one patient exhibiting disturbed nerve sensation of the mental nerve, no major complications were encountered. Overall, this study revealed equal cumulative success rates for standard and Mk II implants after 5 years of observation. Mandibular implants exhibited greater success rates (100%) for both tested implant types compared to maxillary implants (87%).
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