Search: (swepub) lar1:(umu) pers:(Riboli Elio) pers:(Chirlaque Maria Dolores) pers:(Khaw Kay Tee) conttype:(refereed) pers:(Manjer Jonas) spr:eng
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Circulating concent...
Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
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van Duijnhoven, Fraenzel J. B. (author)
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Jenab, Mazda (author)
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Hveem, Kristian (author)
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Siersema, Peter D. (author)
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Fedirko, Veronika (author)
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Duell, Eric J. (author)
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Kampman, Ellen (author)
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Halfweeg, Anouk (author)
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van Kranen, Henk J. (author)
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van den Ouweland, Jody M. W. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Murphy, Neil (author)
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Langhammer, Arnulf (author)
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- Ness-Jensen, Eivind (author)
- Karolinska Institutet
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Olsen, Anja (author)
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Tjonneland, Anne (author)
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Overvad, Kim (author)
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Cadeau, Claire (author)
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Kvaskoff, Marina (author)
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Boutron-Ruault, Marie-Christine (author)
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Katzke, Verena A. (author)
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Kuehn, Tilman (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Kotanidou, Anastasia (author)
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Kritikou, Maria (author)
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Palli, Domenico (author)
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Agnoli, Claudia (author)
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Tumino, Rosario (author)
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Panico, Salvatore (author)
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Matullo, Giuseppe (author)
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Peeters, Petra (author)
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Brustad, Magritt (author)
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Olsen, Karina Standahl (author)
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Lasheras, Cristina (author)
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Obon-Santacana, Mireia (author)
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Sanchez, Maria-Jose (author)
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Dorronsoro, Miren (author)
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Chirlaque, Maria-Dolores (author)
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Barricarte, Aurelio (author)
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Manjer, Jonas (author)
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Almquist, Martin (author)
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- Renström, Frida (author)
- Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden
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- Ye, Weimin (author)
- Karolinska Institutet,Umeå universitet,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Swede
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Wareham, Nick (author)
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Khaw, Kay-Tee (author)
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Bradbury, Kathryn E. (author)
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Freisling, Heinz (author)
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Aune, Dagfinn (author)
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Norat, Teresa (author)
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Riboli, Elio (author)
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Bueno-de-Mesquita, H. B(as) (author)
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(creator_code:org_t)
- 2017-11-22
- 2018
- English.
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In: International Journal of Cancer. - : WILEY. - 0020-7136 .- 1097-0215. ; 142:6, s. 1189-1201
- Related links:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-TrOndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n=626; HUNT2 n=112; median follow-up=6.9 years) were matched to 738 controls. Vitamin D [25(OH)D-2 and 25(OH)D-3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of 25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend=0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend=0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- vitamin D
- pancreatic cancer
- nested case-control study
- cancer epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van Duijnhoven, ...
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Jenab, Mazda
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Hveem, Kristian
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Siersema, Peter ...
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Fedirko, Veronik ...
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Duell, Eric J.
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show more...
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Kampman, Ellen
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Halfweeg, Anouk
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van Kranen, Henk ...
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van den Ouweland ...
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Weiderpass, Elis ...
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Murphy, Neil
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Langhammer, Arnu ...
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Ness-Jensen, Eiv ...
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Olsen, Anja
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Tjonneland, Anne
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Overvad, Kim
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Cadeau, Claire
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Kvaskoff, Marina
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Boutron-Ruault, ...
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Katzke, Verena A ...
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Kuehn, Tilman
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Boeing, Heiner
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Trichopoulou, An ...
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Kotanidou, Anast ...
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Kritikou, Maria
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Palli, Domenico
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Agnoli, Claudia
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Tumino, Rosario
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Panico, Salvator ...
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Matullo, Giusepp ...
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Peeters, Petra
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Brustad, Magritt
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Olsen, Karina St ...
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Lasheras, Cristi ...
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Obon-Santacana, ...
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Sanchez, Maria-J ...
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Dorronsoro, Mire ...
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Chirlaque, Maria ...
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Barricarte, Aure ...
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Manjer, Jonas
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Almquist, Martin
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Renström, Frida
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Ye, Weimin
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Wareham, Nick
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Khaw, Kay-Tee
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Bradbury, Kathry ...
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Freisling, Heinz
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Aune, Dagfinn
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Norat, Teresa
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Riboli, Elio
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Bueno-de-Mesquit ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet