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A Genome-Wide Assoc...
A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
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McKay, James D. (author)
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Truong, Therese (author)
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Gaborieau, Valerie (author)
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show more...
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Chabrier, Amelie (author)
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Chuang, Shu-Chun (author)
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Byrnes, Graham (author)
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Zaridze, David (author)
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Shangina, Oxana (author)
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Szeszenia-Dabrowska, Neonila (author)
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Lissowska, Jolanta (author)
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Rudnai, Peter (author)
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Fabianova, Eleonora (author)
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Bucur, Alexandru (author)
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Bencko, Vladimir (author)
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Holcatova, Ivana (author)
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Janout, Vladimir (author)
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Foretova, Lenka (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Benhamou, Simone (author)
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Bouchardy, Christine (author)
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Ahrens, Wolfgang (author)
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Merletti, Franco (author)
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Richiardi, Lorenzo (author)
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Talamini, Renato (author)
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Barzan, Luigi (author)
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Kjaerheim, Kristina (author)
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Macfarlane, Gary J. (author)
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Macfarlane, Tatiana V. (author)
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Simonato, Lorenzo (author)
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Canova, Cristina (author)
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Agudo, Antonio (author)
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Castellsague, Xavier (author)
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Lowry, Ray (author)
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Conway, David I. (author)
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McKinney, Patricia A. (author)
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Healy, Claire M. (author)
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Toner, Mary E. (author)
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Znaor, Ariana (author)
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Curado, Maria Paula (author)
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Koifman, Sergio (author)
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Menezes, Ana (author)
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Wuensch-Filho, Victor (author)
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Neto, Jose Eluf (author)
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Fernandez Garrote, Leticia (author)
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Boccia, Stefania (author)
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Cadoni, Gabriella (author)
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Arzani, Dario (author)
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Olshan, Andrew F. (author)
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Weissler, Mark C. (author)
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Funkhouser, William K. (author)
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Luo, Jingchun (author)
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Lubinski, Jan (author)
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Trubicka, Joanna (author)
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Lener, Marcin (author)
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Oszutowska, Dorota (author)
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Schwartz, Stephen M. (author)
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Chen, Chu (author)
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Fish, Sherianne (author)
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Doody, David R. (author)
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Muscat, Joshua E. (author)
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Lazarus, Philip (author)
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Gallagher, Carla J. (author)
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Chang, Shen-Chih (author)
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Zhang, Zuo-Feng (author)
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Wei, Qingyi (author)
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Sturgis, Erich M. (author)
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Wang, Li-E (author)
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Franceschi, Silvia (author)
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Herrero, Rolando (author)
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Kelsey, Karl T. (author)
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McClean, Michael D. (author)
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Marsit, Carmen J. (author)
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Nelson, Heather H. (author)
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Romkes, Marjorie (author)
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Buch, Shama (author)
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Nukui, Tomoko (author)
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Zhong, Shilong (author)
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Lacko, Martin (author)
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Manni, Johannes J. (author)
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Peters, Wilbert H. M. (author)
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Hung, Rayjean J. (author)
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McLaughlin, John (author)
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Vatten, Lars (author)
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Njolstad, Inger (author)
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Goodman, Gary E. (author)
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Field, John K. (author)
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Liloglou, Triantafillos (author)
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Vineis, Paolo (author)
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Clavel-Chapelon, Francoise (author)
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Palli, Domenico (author)
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Tumino, Rosario (author)
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Krogh, Vittorio (author)
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Panico, Salvatore (author)
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Gonzalez, Carlos A. (author)
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Ramon Quiros, J. (author)
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Martinez, Carmen (author)
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Navarro, Carmen (author)
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Ardanaz, Eva (author)
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Larranaga, Nerea (author)
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Khaw, Kay-Tee (author)
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Key, Timothy (author)
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Bueno-de-Mesquita, H. Bas (author)
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Peeters, Petra H. M. (author)
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Trichopoulou, Antonia (author)
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Linseisen, Jakob (author)
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Boeing, Heiner (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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Overvad, Kim (author)
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Tjonneland, Anne (author)
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Kumle, Merethe (author)
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Riboli, Elio (author)
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Vaelk, Kristjan (author)
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Voodern, Tonu (author)
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Metspalu, Andres (author)
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Zelenika, Diana (author)
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Boland, Anne (author)
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Delepine, Marc (author)
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Foglio, Mario (author)
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Lechner, Doris (author)
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Blanche, Helene (author)
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Gut, Ivo G. (author)
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Galan, Pilar (author)
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Heath, Simon (author)
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Hashibe, Mia (author)
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Hayes, Richard B. (author)
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Boffetta, Paolo (author)
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Lathrop, Mark (author)
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Brennan, Paul (author)
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(creator_code:org_t)
- 2011-03-17
- 2011
- English.
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In: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 7:3
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p <= 5 x 10(-7)). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1 x 10(-8)) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2 x 10(-8)) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 x 10(-8); rs1229984-ADH1B, p = 7 x 10(-9); and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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McKay, James D.
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Truong, Therese
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Gaborieau, Valer ...
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Chabrier, Amelie
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Chuang, Shu-Chun
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Byrnes, Graham
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show more...
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Zaridze, David
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Shangina, Oxana
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Szeszenia-Dabrow ...
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Lissowska, Jolan ...
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Rudnai, Peter
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Fabianova, Eleon ...
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Bucur, Alexandru
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Bencko, Vladimir
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Holcatova, Ivana
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Janout, Vladimir
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Foretova, Lenka
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Lagiou, Pagona
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Trichopoulos, Di ...
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Benhamou, Simone
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Bouchardy, Chris ...
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Ahrens, Wolfgang
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Merletti, Franco
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Richiardi, Loren ...
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Talamini, Renato
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Barzan, Luigi
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Kjaerheim, Krist ...
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Macfarlane, Gary ...
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Macfarlane, Tati ...
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Simonato, Lorenz ...
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Canova, Cristina
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Agudo, Antonio
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Castellsague, Xa ...
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Lowry, Ray
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Conway, David I.
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McKinney, Patric ...
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Healy, Claire M.
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Toner, Mary E.
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Znaor, Ariana
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Curado, Maria Pa ...
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Koifman, Sergio
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Menezes, Ana
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Wuensch-Filho, V ...
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Neto, Jose Eluf
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Fernandez Garrot ...
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Boccia, Stefania
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Cadoni, Gabriell ...
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Arzani, Dario
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Olshan, Andrew F ...
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Weissler, Mark C ...
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Funkhouser, Will ...
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Luo, Jingchun
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Lubinski, Jan
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Trubicka, Joanna
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Lener, Marcin
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Oszutowska, Doro ...
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Schwartz, Stephe ...
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Chen, Chu
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Fish, Sherianne
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Doody, David R.
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Muscat, Joshua E ...
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Lazarus, Philip
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Gallagher, Carla ...
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Chang, Shen-Chih
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Zhang, Zuo-Feng
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Wei, Qingyi
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Sturgis, Erich M ...
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Wang, Li-E
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Franceschi, Silv ...
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Herrero, Rolando
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Kelsey, Karl T.
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McClean, Michael ...
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Marsit, Carmen J ...
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Nelson, Heather ...
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Romkes, Marjorie
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Buch, Shama
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Nukui, Tomoko
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Zhong, Shilong
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Lacko, Martin
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Manni, Johannes ...
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Peters, Wilbert ...
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Hung, Rayjean J.
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McLaughlin, John
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Vatten, Lars
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Njolstad, Inger
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Goodman, Gary E.
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Field, John K.
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Liloglou, Triant ...
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Vineis, Paolo
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Clavel-Chapelon, ...
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Palli, Domenico
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Tumino, Rosario
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Krogh, Vittorio
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Panico, Salvator ...
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Gonzalez, Carlos ...
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Ramon Quiros, J.
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Martinez, Carmen
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Navarro, Carmen
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Ardanaz, Eva
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Larranaga, Nerea
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Khaw, Kay-Tee
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Key, Timothy
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Trichopoulou, An ...
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Linseisen, Jakob
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Boeing, Heiner
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Hallmans, Göran
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Overvad, Kim
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Tjonneland, Anne
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Kumle, Merethe
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Riboli, Elio
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Vaelk, Kristjan
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Voodern, Tonu
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Metspalu, Andres
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Zelenika, Diana
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Boland, Anne
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Delepine, Marc
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Foglio, Mario
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Lechner, Doris
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Blanche, Helene
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Gut, Ivo G.
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Galan, Pilar
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Heath, Simon
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Hashibe, Mia
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Hayes, Richard B ...
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Boffetta, Paolo
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Lathrop, Mark
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Brennan, Paul
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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PLOS Genetics
- By the university
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Umeå University