| 1. |
- Belfrage, Per, et al.
(författare)
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Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake
- 1977
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Ingår i: European Journal of Clinical Investigation. - : Wiley. - 0014-2972 .- 1365-2362. ; 7:2, s. 127-131
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Tidskriftsartikel (refereegranskat)abstract
- Nine young, healthy male volunteers were given ethanol (75 g/day) for 5 weeks. The ethanol was divided into five daily doses and taken so that blood ethanol levels never exceeded 0.04% (w/v). During the latter part of the ethanol intake period, there was a significant, transient increase of plasma triglyceride (TG) concentrations followed by reduction to normal levels. A three-fold increase of lipoprotein lipase activity (LLA) occurred in biopsy specimens of adipose tissue. An increase of alpha-lipoprotein concentrations, which correlated significantly with the decrease in plasma TG levels and the increase in adipose LLA, was also observed during the ethanol intake period. No changes were observed in plasma cholesterol and beta-lipoprotein levels. A transient, three-fold increase of TG concentrations occurred in liver biopsy specimens. Ultrastructural and cytochemical examinations of the biopsy specimens showed hyperplasia of the smooth endoplasmic reticulum, and increased canallicular activity of gamma-glutamyl transferase (gamma-GT) activity in most subjects towards the end of and after the ethanol intake period. Serum gamma-GT levels also increased significantly.
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| 2. |
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| 3. |
- Tågerud, Sven, et al.
(författare)
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Dopamine release from the rat substantia nigra in vitro. Effect of raphe lesions and veratridine stimulation
- 1979
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Ingår i: Neuroscience. - : Elsevier BV. - 0306-4522. ; 4:12, s. 2021-2029
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Tidskriftsartikel (refereegranskat)abstract
- In order to eliminate the 5-hydroxytryptaminergic input to the substantia nigra lesions were placed in the dorsal and medial raphe nuclei in a number of rats. The release of exogenously applied [3H]dopamine from the partially denervated substantia nigra was determined in vitro and found to be very similar to the release observed from slices of control substantia nigra. These results lend further support to the theory that the release of exogenously applied [3H]dopamine at the level of the substantia nigra occurs mainly from dopaminergic dendrites, rather than from terminals of 5-hydroxytryptamine-containing neurons. A veratridine-induced release of [3H]dopamine from the pars reticulata of the substantia nigra is also described. An almost complete blockade of veratridine (3.0 μM) stimulation was observed with 100 nM tetrodotoxin. Similar effects of veratridine and tetrodotoxin were also observed on [3H]dopamine release from slices of corpus striatum. These results suggest that dendrites of the dopaminergic neurones in the substantia nigra contain fast, tetrodotoxin-sensitive sodium channels.
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| 4. |
- Nilsson-Ehle, Peter, et al.
(författare)
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Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects
- 1978
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Ingår i: Lipids. - 0024-4201. ; 13:6, s. 433-437
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Tidskriftsartikel (refereegranskat)abstract
- Ethanol (ca. 1 g/kg body weight) was given alone or together with glucose or lipid (mixed triglycerides) perorally to young, fasting subjects. The changes with time (0-6 hr) of lipoprotein lipase activity (LLA) in adipose tissue, plasma glycerol, triglyceride, insulin, blood glucose, and alcohol concentrations were followed. A maximal mean blood alcohol concentration of 0.09% (w/v) was obtained 1 hr after ingestion with no apparent intoxicating effects. Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlstrom, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid. Confirming results by others, ethanol intake decreased plasma glycerol concentration and increased plasma triglycerides, especially after intake of lipid. It is suggested that ethanol intake interferes with the normal carbohydrate-induced elevation of adipose tissue LLA after a mixed meal, thereby decreasing the removal capacity for circulating dietary lipid and causing enhanced and prolonged alimentary hyperlipemia.
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| 5. |
- Nilsson-Ehle, Peter, et al.
(författare)
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Specific conditions for enhancement of lipoprotein lipase activity by platelets
- 1975
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Ingår i: Life Sciences. - : Elsevier BV. - 1879-0631 .- 0024-3205. ; 16:11, s. 1703-1709
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Tidskriftsartikel (refereegranskat)abstract
- Homogenates of human blood platelets, but not of red blood cells, have been found to stimulate lipoprotein lipase activity only when assayed against an emulsified triglyceride substrate sonicated for a short period of time. The degree of stimulation was inversely related to the time of sonication of the substrate. Using chylomicrons as substrate no stimulation of lipoprotein lipase activity by platelet homogenate was seen.
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| 6. |
- Ahlenius, Sven, et al.
(författare)
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Prolongation of the ejaculation latency in the male rat by thioridazine and chlorimipramine.
- 1979
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Ingår i: Psychopharmacology. - 0033-3158 .- 1432-2072. ; 65:2, s. 137-140
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Tidskriftsartikel (refereegranskat)abstract
- Thioridazine (3 mg/kg) and chlorimipramine (1.5–6.0 mg/kg) prolonged the ejaculation latency and increased the number of mounts but did not change the number of intromissions preceding ejaculation. Blockade of peripheral and central noradrenaline receptors by phentolamine and phenoxybenzamine respectively resulted in a suppression of all aspects of the sexual behavior with increasing doses. dl-5-HTP (25–100 mg/kg) in combination with an inhibitor of peripheral 5-HTP decarboxylase (benserazide, 25 mg/kg) produced, like chlorimipramine and thioridazine, a prolongation of ejaculation latency and an increase in the number of mounts preceding ejaculation. Selective inhibition of 5-HT reuptake however, by zimelidine (0–20 mg/kg) or alaproclate (0–20 mg/kg) did not affect the mating behavior. At higher doses of these drugs some animals failed to initiate sexual activities. There was an increase in the postejaculatory interval but no change in the ejaculatory latency.It is concluded that the prolonged ejaculation latencies observed following treatment with thioridazine or chlorimipramine is not due to a blockade of central or peripheral adrenergic -receptors.
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| 7. |
- Alm, Bernt, 1951
(författare)
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Piperidine: effects on locomotor activity and brain monoamine turnover
- 1976
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Ingår i: Psychopharmacology (Berl). - 0033-3158. ; 50:3, s. 301-4
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Tidskriftsartikel (refereegranskat)abstract
- The effects of piperidine HCl (PHCl) on locomotor activity, flexor reflex activity and monoamine levels, turnover, and synthesis were studied. Results indicate a sedative action and an increased turnover of noradrenaline (NA), but no effects on 5-hydroxytryptamine (5-HT) or dopamine (DA). Data obtained from flexor reflex experiments suggest that this is not secondary to alpha-adrenergic receptor blockade. One explanation might be an increased impulse activity of NA neurons, but the exact mechanism remains to be elucidated.
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