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- Spak, Fredrik, 1948, et al.
(författare)
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[The Gothenburg study of women and alcohol: problems during childhood and adolescence important risk factors]
- 2001
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Ingår i: Lakartidningen. - 0023-7205. ; 98:10, s. 1109-14
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Tidskriftsartikel (refereegranskat)abstract
- This is a part of longitudinal study concerning women and alcohol in Gothenburg. The aim was to find out more about risk factors for alcohol dependence and abuse (ADA) among women in the general population, as well as social conditions and life style among these women. Several indicators of dissatisfactory childhood conditions, and particularly sexual abuse before age 13, were related to ADA in adulthood. Early substance abuse, such as having been intoxicated before age 15 and having used narcotics before 18, was strongly related to future ADA. Our findings point to the need of paying attention to mental health problems in childhood and youth, and to prevent early use of alcohol and drugs.
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| 2. |
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| 3. |
- Andréasson, Sven, et al.
(författare)
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Behandling av alkohol- och narkotikaproblem : En evidensbaserad kunskapssammanställning
- 2001
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Utvärderingens syfteMissbruk och beroende av alkohol är ett av de största folkhälsoproblemen. Narkotikamissbruk är mindre vanligt men har stora medicinska konsekvenser för de berörda. De sociala och juridiska aspekterna är betydande. En kritisk genomgång av litteraturen vad avser behandling av abstinens, protraherad abstinens, behandling i syfte att förhindra återfall, psykologiska och sociala behandlingar för att minska återfallsrisken, behandlingsprogram och institutionsvårdens roll, samt behandling av missbruk under graviditet. Dessutom en granskning av mini-intervention i primärvård och annan vård vars syfte är att minska konsumtionen hos högkonsumenter av alkohol. Nyligen gjorda meta-analyser inom området värderas och särskild vikt fästs vid interventioner som finns eller lätt kan introduceras i den svenska vårdorganisationen. Behandlingsprogram för patienter med samtidig annan psykisk störning värderas.Så kallat lågdosberoende av bensodiazepiner och andra lugnande medel eller sömnmedel behandlas inte. Inte heller belyses effekten av behandlingar vars primära mål är kroppsliga komplikationer av missbruket, och inte heller granskas metoder att minska tillgänglighet.TillvägagångssättStrukturerad översikt, kostnadsanalyser.Insamling av primärdataSystematisk sökning i relevanta databaser, litteraturlistor i påträffade studier samt i aktuella monografier. Ingen bakre tidsbegränsning och sökning i databaser till och med februari 1999.Utgångspunkt för urval av dataHuvudsakligen randomiserade, kontrollerade, dubbelblinda studier, samt metaanalyser som baseras på sådana studier. Vad gäller långtidsförlopp och ekonomiska analyser även kohortstudier och andra naturalistiska studier.Genomgång av publikationenSamtliga studier värderas med hjälp av en i gruppen utarbetad, och med övriga psykiatriprojekt gemensam, kvalitetsmall. Alla centrala studier läses av minst två i gruppen.Färdiga manuskript värderas av styrelse, expertgrupp samt externa granskare.
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| 4. |
- Lundgren, Kata, et al.
(författare)
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Childhood abuse and neglect in severely dependent female addicts : Homogeneity and reliability of a Swedish version of the Childhood Trauma Questionnaire.
- 2002
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Ingår i: International Journal of Social Welfare. - : Wiley. - 1369-6866 .- 1468-2397. ; 11:3, s. 219-227
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The study explores the psychometric characteristics of "Barndomsupplevelser", a Swedish translation of the 53-item version of the Childhood Trauma Questionnaire (CTQ). Method: Fifty-five female addicts, treated at a compulsory care setting completed the questionnaire. Homogeneity and reliability was studied using Principal component analyses (PCA) and Cronbach´s alpha. The test was submitted to content analysis. Results: Nearly all (94,5 percent) had experienced childhood abuse or neglect. The internal consistency is high. The 4-factor solution corresponded to the subscales of emotional and physical abuse (combined), of sexual abuse and of emotional neglect, while the items in the physical neglect subscale were distributed to several factors. In the 5-factor solution, this subscale was divided into two factors. Content analyses of these factors point to other meanings than physical neglect. Conclusion: The CTQ (Swedish translation) was found to have high consistency and homogeneity in four of the five subscales (emotional, physical and sexual abuse and emotional neglect), while the subscale on physical neglect may need revision. The new 28-item brief version seems to be an improvement, in regards to these problems.
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| 6. |
- Allebeck, Peter, 1952, et al.
(författare)
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Gothenburg study of women and alcohol: Low prevalence of abuse - trend toward increase appears to have abated : Studie i Göteborg om kvinnor och alkohol: Låg förekomst av missbruk - ökningen förefaller ha avklingat
- 2001
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Ingår i: Läkartidningen. - 0023-7205. ; 98:10, s. 1103-07
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Tidskriftsartikel (refereegranskat)abstract
- Prevalence of alcohol dependence and abuse (ADA) was determined in a cohort of women selected by stratified random sampling from the general population in Gothenburg. A questionnaire was administered to 3,130 women and 399 were interviewed. Questions were asked about social background, living conditions, family and working life. Volume and frequency of alcohol intake were recorded, and diagnoses were made according to DSM-III. We found that the one-year prevalence of ADA was 1.5 percent and the life time prevalence 3.3 percent. In a follow-up five years after base-line, the prevalence of ADA was unchanged, while indicators of high alcohol consumption and high episodic drinking showed reduced levels of problem drinking.
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| 9. |
- Lê, A D, et al.
(författare)
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Neurobiological processes in alcohol addiction.
- 2001
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Ingår i: Alcoholism, clinical and experimental research. - 0145-6008. ; 25:5 Suppl ISBRA
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Forskningsöversikt (refereegranskat)abstract
- This article represents the proceedings of a symposium at the ISBRA Meeting in Yokohama, Japan. The chairs were A. D. Lê and K. Kiianmaa. The presentations were (1) Alcohol reward and aversion, by C. L. Cunningham; (2) The role of sensitization of neuronal mechanisms in ethanol self-administration, by J. A. Engel, M. Ericson, and B. Söderpalm; (3) Alcohol self-administration in dependent animals: Neurobiological mechanisms, by G. F. Koob, A. J. Roberts, and F. Weiss; (4) Stress and relapse to alcohol, by A. D. Lê; (5) Alcohol-preferring AA and alcohol-avoiding ANA rats differ in locomotor activation induced by repeated morphine injections, by P. Hyytiä, S. Janhunen, J. Mikkola, P. Bäckström, and K. Kiianmaa; and (6) Initial sensitivity and acute functional tolerance to the hypnotic effects of ethanol in mice genetically selected for mild and severe ethanol withdrawal convulsions, by I. Ponomarev and J. C. Crabbe.
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| 10. |
- Svensson, Anders I, 1969, et al.
(författare)
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Gonadectomy enhances shock-induced behavioral inhibition in adult male rats: implications for impulsive behavior.
- 2000
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Ingår i: Pharmacology, biochemistry, and behavior. - 0091-3057. ; 65:4, s. 731-6
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Tidskriftsartikel (refereegranskat)abstract
- The effects of gonadectomy on shock-induced behavioral inhibition in a modified Vogel's drinking conflict model and on diazepam-induced disinhibition and sedation were investigated in adult male rats. Gonadectomy enhanced shock-induced behavioral inhibition when determined 9, 21, 45, and 65 days, but not 3 days, after operation, without affecting shock sensitivity or drinking motivation. Testosterone-substitution for 21 days following gonadectomy prevented this enhanced inhibition without significantly affecting the behavior in sham-operated rats. Diazepam produced behavioral disinhibition both in sham-operated and gonadectomized rats. However, after the highest dose (16 mg/kg, IP) the disinhibited behavior decreased only in sham-operated animals, most likely due to sedation. Moreover, whereas there was no difference in basal rotarod-performance between controls and gonadectomized rats, the latter animals were less sensitive to diazepam-induced disruption of rotarod walking ability. Sham-operated or gonadectomized animals did not differ with respect to serum diazepam levels at the postinjection times used in the behavioral tests. Taken together, gonadectomized rats were less sensitive towards diazepam-induced sedation, possibly due to a subsensitivity at or beyond GABA(A)/benzodiazepine receptors. Furthermore, the finding that lack of testosterone enhanced shock-induced inhibition could be interpreted to reflect increased impulse control and may involve an altered activation of GABA(A)/benzodiazepine receptors.
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