| 1. |
- Hellström, Lisa, et al.
(författare)
-
What role does health have in today’s teacher education? What role should it have?
- 2024
-
Konferensbidrag (refereegranskat)abstract
- The role of health in teacher education is a subject of discussion and development. Prioritizing health in teacher education may be of importance, especially given the increasing awareness of mental health and other health-related challenges that students may face. The strong correlation between health and learning also underscores the importance of a more explicit focus on health in teacher education. Health in teacher education is a multifaceted and important aspect that encompasses various dimensions of well-being. It is not limited to physical health but also includes mental, emotional, and social well-being. The role of health in education is to ensure that students are provided with an environment that supports their holistic development and prepares them to lead healthy and fulfilling lives. While children and school students show increasing challenges related to health, we also see that teachers report high levels of work-related stress and that many leave the profession prematurely. Research indicates that a part of this is due to inadequate preparation in teacher training for the reality of being a practicing teacher. Health should be integrated into teacher education in a way that equips teachers to support students' physical and mental health while providing high-quality education. It has been argued for decades that health education (HE) should be anchored more firmly in school curricula. Nevertheless, only a few countries have introduced HE as a stand-alone school subject.The role of health in today's teacher education can vary depending on the education program, schools, and institutions. However, in general, health is an important aspect of teacher education and teaching. Some considerations are:- Health as a subject: Teacher education may include subjects related to physical, mental, and social health to teach teachers how to promote healthy habits and well-being among students.- Health-promoting school environment: Teacher education can also focus on creating a health-promoting school environment where both physical and psychosocial aspects of students' well-being are considered. Purpose and expected outcomes of the workshop: We want to open up a dialogue about the role of health in today´s teacher education. What is health and health-promotion in a school context and how can teachers work to promote health? What are teachers’ responsibilities and how can teacher training equip teachers to support students’ health? We hope that this workshop will open up for a genuine discussion about health and its’ role for teachers and teacher training. We also want to investigate opportunities to arrange further workshops and initiate research collaborations.
|
|
| 2. |
|
|
| 3. |
- Leden, Lotta, et al.
(författare)
-
Literary texts in upper secondary science teacher education
- 2024
-
Konferensbidrag (populärvet., debatt m.m.)abstract
- This presentation discusses why and how literary texts could be incorporated in science teacher education as a step towards increasing the relevance of school science. Previous research has suggested that using literary texts in science teaching can facilitate science learning as well as contribute to enhanced social justice in various ways. The presentation describes and evaluates experiences from a non-mandatory book-club project that was implemented in science teacher education. Five upper secondary pre-service science teachers took part in the book club (1 year, 4 meetings) and shared their experiences in a focus-group interview at the end of the project. The analysis of the interview shows that the pre-service teachers expect the same kind of benefits from using literary texts in their teaching as suggested in previous research, but that these expectations do not fully align with their ideas of how their future teaching might be orchestrated. We discuss how an incorporation of literary texts in science teacher education must be accompanied by opportunities for didactic analysis related to different choices for teaching, and the consequences of such choices for students’ possibilities to learn and take part in science.
|
|
| 4. |
- Lodin, Karin, et al.
(författare)
-
Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies : A longitudinal study
- 2024
-
Ingår i: Seminars in Arthritis & Rheumatism. - : Elsevier. - 0049-0172 .- 1532-866X. ; 65
-
Tidskriftsartikel (refereegranskat)abstract
- AimTo explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM).MethodsPGA and systemic inflammatory markers prospectively collected over five years were retrieved from the International MyoNet registry for 1200 patients with IIM. Associations between PGA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and creatine kinase (CK) were analyzed using mixed models. Mediation analysis was used to test if the association between PGA and inflammatory markers during the first year of observation could be explained by measures of disease activity and function.ResultsPGA improved, and inflammatory markers decreased during the first year of observation. In the mixed models, high levels of inflammatory markers were associated with worse PGA in both men and women across time points during five years of observation. In men, but not in women, the association between elevated ESR, CRP and poorer PGA was explained by measures of function and disease activity. With a few exceptions, the association between improved PGA and reduced inflammatory markers was partially mediated by improvements in all measures of function and disease activity.ConclusionIncreased levels of systemic inflammation are associated with poorer PGA in patients with IIM. In addition to known benefits of lowered inflammation, these findings emphasize the need to reduce systemic inflammation to improve subjective health in patients with IIM. Furthermore, the results demonstrate the importance of incorporating PGA as an outcome measure in clinical practice and clinical trials.
|
|
| 5. |
- Segerby, Cecilia, et al.
(författare)
-
Vikten av tidiga specialpedagogiska insatser i förskolan för en framgångsrik skolgång
- 2024
-
Ingår i: Nordisk Barnehageforskning. ; 3:21, s. 118-142
-
Tidskriftsartikel (refereegranskat)abstract
- I Sverige har föräldrar möjlighet att bestämma över sina barns vistelse innan skolstart, vilken kan bestå av förskola, pedagogisk omsorg eller i hemmet. Dock är det endast förskolan som har fått en skolförberedande roll gällande barns språk- och kunskapsutveckling. Det är problematiskt eftersom forskning visar på vikten av tidig identifiering och stöttning angående barn som befinner sig i språklig sårbarhet. I denna studie används longitudinella data från sex elever födda 2003 till och med årskurs 6 i en kommun i Sverige vilka tidigt identifierats vara i behov av specialpedagogiskt stöd gällande deras språkutveckling. Syftet med studien är att få en fördjupad bild av identifieringen och det specialpedagogiska stödet för dessa barn i språklig utsatthet. Dessutom är syftet också att jämföra det specialpedagogiska stödet med barnens resultat i svenskämnet till årskurs 6. Empirin består av två dokument; intervju med de två specialpedagoger som är involverade med barnen före skolstart, mejlkorrespondens med en specialpedagog som har det övergripande ansvaret i kommunen, en av rektorerna från skolorna samt resultat från nationella prov i årskurs 3 och årskurs 6 i svenska och betyg i svenska i årskurs 6. Resultaten indikerar betydelsen av tidiga specialpedagogiska insatser i förskolan för en framgångsrik skolgång.
|
|
| 6. |
- Andersson, Helena, et al.
(författare)
-
Walking football for Health - physiological response to playing and characteristics of the players.
- 2023
-
Ingår i: Science and medicine in football. - : Routledge. - 2473-3938 .- 2473-4446. ; , s. 1-8
-
Tidskriftsartikel (refereegranskat)abstract
- Walking Football (WF) is one type of recreational football increasing in popularity, targeting older adults. Further knowledge on the intensity and physical workload of WF, characteristics of the players, the social context, and reasons for playing WF is needed. Thus, the aim of the study was to characterize the individuals that regularly play WF and their experience of WF, and the physiological characteristics of the sport. Sixty-three players from three clubs taking part in organised WF in Sweden were included. The players participated in up to four WF-games and underwent performance tests and answered a questionnaire. The participants mean age was 70.9 years, ranging from 63 to 85 years with 71% (n = 27) of the men and 68% (n = 13) of the women having a BMI > 25. Fifty-one percent (n = 27) of the players had hypertension, and 73% (n = 39) regularly used prescription drugs due to illness. During WF, the players covered on average 2,409 m (2,509 m for men and 2,205 m for women, p = .001). Expressed in percentage of their age-estimated maximal heart rate, mean heart rate represented 80 ± 9 and 80 ± 8% of max for men, and 78 ± 9 and 79 ± 9% of max for women in the first and second halves, respectively, hence WF can be considered a moderate intensity activity for older adults. The main reason for WF participation was to socialize. WF includes a considerable number of accelerations and decelerations, making it more energetically and mechanically demanding than walking.
|
|
| 7. |
- Leclair, Valerie, et al.
(författare)
-
Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies
- 2023
-
Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 96
-
Tidskriftsartikel (refereegranskat)abstract
- Background In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles are associated with specific HLA genetic variants and clinical manifestations in IIM. Methods We included 1348 IIM patients and determined the occurrence of 14 myositis-specific or-associated autoantibodies. We used unsupervised cluster analysis to identify autoantibody-defined subgroups and logistic regression to estimate associations with clinical manifestations, HLA-DRB1, HLA-DQA1, HLA-DQB1 alleles, and amino acids imputed from genetic information of HLA class II and I molecules. Findings We identified eight subgroups with the following dominant autoantibodies: anti-Ro52, -U1RNP, -PM/Scl,-Mi2,-Jo1,-Jo1/Ro52,-TIF1 gamma or negative for all analysed autoantibodies. Associations with HLA-DRB1*11, HLA-DRB1*15, HLA-DQA1*03, and HLA-DQB1*03 were present in the anti-U1RNP-dominated subgroup. HLA-DRB1*03, HLA-DQA1*05, and HLA-DQB1*02 alleles were overrepresented in the anti-PM/Scl and anti-Jo1/ Ro52-dominated subgroups. HLA-DRB1*16, HLA-DRB1*07 alleles were most frequent in anti-Mi2 and HLA- DRB1*01 and HLA-DRB1*07 alleles in the anti-TIF1 gamma subgroup. The HLA-DRB1*13, HLA-DQA1*01 and HLA-DQB1*06 alleles were overrepresented in the negative subgroup. Significant signals from variations in class I molecules were detected in the subgroups dominated by anti-Mi2, anti-Jo1/Ro52, anti-TIF1 gamma, and the negative subgroup. Interpretation Distinct HLA class II and I associations were observed for almost all autoantibody-defined subgroups. The associations support autoantibody profiles use for classifying IIM which would likely reflect underlying pathogenic mechanisms better than classifications based on clinical symptoms and/or histopathological features. Funding See a detailed list of funding bodies in the Acknowledgements section at the end of the manuscript. Copyright (c) 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
|
|
| 8. |
- Lu, Zijia, et al.
(författare)
-
Multiple enzymatic approaches to hydrolysis of fungal β-glucans by the soil bacterium Chitinophaga pinensis
- 2023
-
Ingår i: The FEBS Journal. - : Wiley. - 1742-464X .- 1742-4658. ; 290:11, s. 2909-2922
-
Tidskriftsartikel (refereegranskat)abstract
- The genome of the soil Bacteroidota Chitinophaga pinensis encodes a large number of glycoside hydrolases (GHs) with noteworthy features and potentially novel functions. Several are predicted to be active on polysaccharide components of fungal and oomycete cell walls, such as chitin, β-1,3-glucan and β-1,6-glucan. While several fungal β-1,6-glucanase enzymes are known, relatively few bacterial examples have been characterised to date. We have previously demonstrated that C. pinensis shows strong growth using β-1,6-glucan as the sole carbon source, with the efficient release of oligosaccharides from the polymer. We here characterise the capacity of the C. pinensis secretome to hydrolyse the β-1,6-glucan pustulan and describe three distinct enzymes encoded by its genome, all of which show different levels of β-1,6-glucanase activity and which are classified into different GH families. Our data show that C. pinensis has multiple tools to deconstruct pustulan, allowing the species' broad utility of this substrate, with potential implications for bacterial biocontrol of pathogens via cell wall disruption. Oligosaccharides derived from fungal β-1,6-glucans are valuable in biomedical research and drug synthesis, and these enzymes could be useful tools for releasing such molecules from microbial biomass, an underexploited source of complex carbohydrates.
|
|
| 9. |
- Bianchi, Matteo, et al.
(författare)
-
Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort
- 2022
-
Ingår i: Arthritis & Rheumatology. - : John Wiley & Sons. - 2326-5191 .- 2326-5205. ; 74:2, s. 342-352
-
Tidskriftsartikel (refereegranskat)abstract
- Objective Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of complex autoimmune conditions characterized by inflammation in skeletal muscle and extramuscular compartments, and interferon (IFN) system activation. We undertook this study to examine the contribution of genetic variation to disease susceptibility and to identify novel avenues for research in IIMs.Methods Targeted DNA sequencing was used to mine coding and potentially regulatory single nucleotide variants from ~1,900 immune-related genes in a Scandinavian case–control cohort of 454 IIM patients and 1,024 healthy controls. Gene-based aggregate testing, together with rare variant– and gene-level enrichment analyses, was implemented to explore genotype–phenotype relations.Results Gene-based aggregate tests of all variants, including rare variants, identified IFI35 as a potential genetic risk locus for IIMs, suggesting a genetic signature of type I IFN pathway activation. Functional annotation of the IFI35 locus highlighted a regulatory network linked to the skeletal muscle–specific gene PTGES3L, as a potential candidate for IIM pathogenesis. Aggregate genetic associations with AGER and PSMB8 in the major histocompatibility complex locus were detected in the antisynthetase syndrome subgroup, which also showed a less marked genetic signature of the type I IFN pathway. Enrichment analyses indicated a burden of synonymous and noncoding rare variants in IIM patients, suggesting increased disease predisposition associated with these classes of rare variants.Conclusion Our study suggests the contribution of rare genetic variation to disease susceptibility in IIM and specific patient subgroups, and pinpoints genetic associations consistent with previous findings by gene expression profiling. These features highlight genetic profiles that are potentially relevant to disease pathogenesis.
|
|
| 10. |
- Lundtoft, Christian, et al.
(författare)
-
Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
- 2022
-
Ingår i: Arthritis & Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 74:8, s. 1440-1450
-
Tidskriftsartikel (refereegranskat)abstract
- Objective Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation is connected to the autoimmune repertoire in systemic lupus erythematosus (SLE), primary Sjogrens syndrome (SS), or myositis. Methods Using targeted DNA sequencing, we determined the copy number and genetic variants of C4 in 2,290 well-characterized Scandinavian patients with SLE, primary SS, or myositis and 1,251 healthy controls. Results A prominent relationship was observed between C4A copy number and the presence of SSA/SSB autoantibodies, which was shared between the 3 diseases. The strongest association was detected in patients with autoantibodies against both SSA and SSB and 0 C4A copies when compared to healthy controls (odds ratio [OR] 18.0 [95% confidence interval (95% CI) 10.2-33.3]), whereas a weaker association was seen in patients without SSA/SSB autoantibodies (OR 3.1 [95% CI 1.7-5.5]). The copy number of C4 correlated positively with C4 plasma levels. Further, a common loss-of-function variant in C4A leading to reduced plasma C4 was more prevalent in SLE patients with a low copy number of C4A. Functionally, we showed that absence of C4A reduced the individuals capacity to deposit C4b on immune complexes. Conclusion We show that a low C4A copy number is more strongly associated with the autoantibody repertoire than with the clinically defined disease entities. These findings may have implications for understanding the etiopathogenetic mechanisms of systemic inflammatory autoimmune diseases and for patient stratification when taking the genetic profile into account.
|
|
