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1989 med svenska ögon : Vittnesseminarium 22 oktober 2009
- 2010. - 1
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Året 1989 innebar en vändpunkt i den europeiska historien, och även i världsmåttstock. Berlinmuren raserades och de kommunistiska diktaturerna i Östeuropa föll samman, bara för att inom ett par år även följas av det sovjetiska imperiet. Demokratiska regimer uppstod, om än under vånda och med senare bakslag.Tjugo år efter händelserna anordnades ett vittnesseminarium vid Södertörns högskola på temat 1989 med svenska ögon. Seminariet med dess kommentarer från diplomatin, underrättelsetjänsten och massmedia återges i skriften. Förstod vi vad som hände i öst?
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Peaceful Coexistence? : Soviet Union and Sweden in the Khrushchev era
- 2010. - 1
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Forty-five years ago Nikita Khrushchev visited Sweden. Also, forty-five years ago the epoch in Soviet history that is connected with his name ended. This book has its origin in contributions to a conference in 2004 called the ‘Peaceful co-existence? Relations between the USSR and Sweden during the Khrushchev era 1953–1964’. The aim of the conference was to present research endeavours undertaken in the field of Soviet foreign policy and relations with the world in the 1990’s and the 2000’s when critical archival documents on Soviet history were made accessible for the scholarly world both inside and outside Russia. Furthermore, the aims of the conference were to discuss central lines of Soviet and Swedish foreign policy and the main events in Soviet-Swedish relations in the years of Khrushchev regime.
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- Fröjmark, Anne-Sophie, 1979-
(författare)
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Molecular Studies of Diamond-Blackfan Anemia and Congenital Nail Dysplasia
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis is to investigate the effect of genetic mutations on the pathophysiology of two human disorders: Diamond-Blackfan Anemia (DBA) and isolated congenital nail dysplasia. The first part of this thesis (Paper I-III) investigates the mechanism associated with DBA. DBA is a rare bone marrow failure syndrome characterized by the absence or decrease of erythroid precursor cells. The disease is further associated with growth retardation, malformations, predisposition to malignant disease and heterozygous mutations in ribosomal protein (RP) genes. The second part of this thesis (Paper IV) investigates the genetic basis of isolated autosomal recessive nail dysplasia characterized by pachyonychia and onycholysis of both finger- and toenails. It further dissects the molecular mechanisms regulating nail development. In the first study, we investigated the previously reported RPS19/PIM-1 interaction by generating a combined Rps19/Pim-1 knockout mouse model. We found that allelic Rps19 insufficiency and Pim-1 deficiency have a cooperative effect on murine hematopoiesis resulting in increased myeloid cellularity associated with cell cycle alterations and reduced apoptosis. In the second study, we analyzed primary fibroblasts from DBA patients with truncating mutations in RPS19 or RPS24 and observed a marked delay in cellular growth associated with specific cell cycle defects. In the third study, we discovered that recombinant RPS19 binds its own mRNA and that the binding is altered when two DBA-associated RPS19 mutations are introduced. In the fourth study, we identified mutations in the WNT signaling receptor Frizzled 6 (FZD6). We observed that the nonsense mutant fails to interact with the first downstream effector Dishevelled. Fzd6 mutant mice displayed claw malformations and we detected a transient Fzd6 expression in the distal digits at the embryonic time point for nail development. In summary, this thesis elucidates several mechanisms in the etiology of DBA and congenital nail dysplasia and mechanisms regulating nail development.
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