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Träfflista för sökning "L773:0021 9150 OR L773:1879 1484 srt2:(1972-1979)"

Sökning: L773:0021 9150 OR L773:1879 1484 > (1972-1979)

  • Resultat 1-2 av 2
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1.
  • Carlson, Lars A., et al. (författare)
  • A case of massive hypertriglyceridemia corrected by nicotinic acid or nicotinamide therapy
  • 1972
  • Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 16:3, s. 359-368
  • Tidskriftsartikel (refereegranskat)abstract
    • A case of massive hypertriglyceridemia with fasting plasma triglycerides around 100 mmoles/l is described. Large amounts of chylomicra were present in fasting plasma and the amounts of low-density and high-density lipoproteins were very low. Postheparin plasma lipolytic activity was normal and intravenous heparin rapidly cleared the patient's abnormally prolonged alimentary lipemia with a concomitant rise in plasma free fatty acid levels.Nicotinic acid or nictotinamide given in doses of 3 g or more daily reduced plasma triglyceride levels to about 2–3 mmoles/1 and raised the reduced levels of low and high-density lipoproteins. The mode of onset of this therapeutic effect was slow and the effect persisted for several weeks after withdrawal of either nicotinic acid or nicotinamide.The pathogenesis of the hypertriglyceridemia as well as the mode of action of nicotinic acid and nicotinamide is discussed.
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2.
  • Carlson, Lars A., et al. (författare)
  • Effect of chlorophenoxyisobutyric acid (CPIB) on fat-mobilizing lipolysis and cyclic AMP levels in rat epididymal fat
  • 1972
  • Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 16:3, s. 349-357
  • Tidskriftsartikel (refereegranskat)abstract
    • High concentrations of chlorophenoxyisobutyric acid (CPIB) reduced basal glycerol release from rat epididymal fat pads in vitro and antagonized the lipolytic effects of noradrenaline. Furthermore, very high concentrations of CPIB significantly antagonized the effects or noradrenaline or ACTH on cyclic AMP accumulation by isolated rat adipocytes. These data are not incompatible with the hypothesis that a primary mechanism in the hypolipidemic action of CPIB is to lower the levels of cyclic AMP in adipose tissue, resulting in decreased hormone-sensitive lipase activity and/or increased lipoprotein lipase activity.
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  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Carlson, Lars A. (2)
Walldius, Göran (1)
Fröberg, Sven (1)
Oro, L. (1)
Butcher, R.W. (1)
Lärosäte
Uppsala universitet (2)
Språk
Engelska (2)
År
1972 (2)

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