| 1. |
- Axelsson, Per, 1933
(författare)
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Commentary: periodontitis is preventable
- 2014
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Ingår i: Journal of Periodontology. - Chicago : Wiley. - 0022-3492 .- 1943-3670. ; 85:10, s. 1303-7
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Buranawat, B, et al.
(författare)
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Evaluation of a Beta-Calcium Metaphosphate Bone Graft Containing Bone Morphogenetic Protein- 7 (OP-1) in Rabbit Maxillary Defects.
- 2014
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Ingår i: Journal of periodontology. - : Wiley. - 1943-3670 .- 0022-3492. ; 85:2, s. 298-307
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Tidskriftsartikel (refereegranskat)abstract
- Background: Calcium phosphate based materials have been widely used as bone substitutes and more recently are being exploited together with growth factors as bone tissue engineering scaffolds regulating cell behavior. The aim of the study was to evaluate the in vitro and in vivo response to a newly developed calcium metaphosphate bone graft, with and without bone stimulating growth factor. Materials and methods: Porous scaffolds of β calcium metaphosphate (CMP) were developed and extensively tested in vitro. Subsequently, CMP grafts with osteogenic protein 1 (OP-1) (test) and, without (control) were implanted into experimental rabbit maxillary bone defects. Animals were sacrificed 2, 4, and 8 weeks and samples examined with micro-computed tomography (µCT) and processed for histomorphometric analysis. Results: At 8 weeks the scaffolds containing OP-1 induced greater bone formation (P=0.018) than CMP alone, based on histomorphometric evaluation, % Bone area [Test 57.1±5.6 and Control 49.4±7.7] and micro-CT analysis, % Bone volume density (BV/TV) [Test 63.46±5.61 and Control 51.20±6.71]. Thus, this data indicated that both test and control CMP grafts showed a good degree of bone formation. Furthermore, the CMP materials showed signs of resorption from 4 weeks and no graft materials were observed at 8 weeks. Conclusion: In vitro the OP-1 loaded graft demonstrated a release profile and bioactivity over a 28 day period. In vivo testing confirmed enhanced bone formation of the OP-1 loaded graft after 8 weeks of healing.
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| 3. |
- Carlsson, Björn, 1980-, et al.
(författare)
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Evaluation of a roughness length model and sea surface properties with data from the Baltic Sea
- 2010
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Ingår i: Journal of Physical Oceanography. - 0022-3670 .- 1520-0485. ; 40:9, s. 2007-2024
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Tidskriftsartikel (refereegranskat)abstract
- The exchange of momentum between the oceans and atmosphere is important for many atmospheric and oceanic processes and is mainly governed by the roughness of sea surface. The roughness can be expressed by a roughness length z0. A roughness length model, based on the concept that z0 is determined by stochastic wave breaking, is presented. The model performance is evaluated using measurements from the Östergarnsholm site, in the Baltic Sea, and pertinent information from other recent investigations. The wave field and the roughness length variations are investigated during various sea state conditions dominated by wind-driven waves. It is found that several parameters, describing the characteristics of the wave field, are dependent on the amount of energy that long waves have relative to the energy of short, wind-driven waves of the sea spectrum (called the swell ratio). The impact of swell ratio on z0 can explain the discrepancies found in various results among relevant investigations. The roughness length model can well reproduce the observed roughness length.
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| 4. |
- Chai, Wen Lin, et al.
(författare)
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Development of a novel model for the investigation of implant-soft tissue interface.
- 2010
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Ingår i: Journal of periodontology. - : Wiley. - 1943-3670 .- 0022-3492. ; 81:8, s. 1187-95
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In dental implant treatment, the long-term prognosis is dependent on the biologic seal formed by the soft tissue around the implant. The in vitro investigation of the implant-soft tissue interface is usually carried out using a monolayer cell-culture model that lacks a polarized-cell phenotype. This study developed a tissue-engineered three-dimensional oral mucosal model (3D OMM) to investigate the implant-soft tissue interface. METHODS: A 3D OMM was constructed using primary human oral keratinocytes and fibroblasts cultured on a skin-derived scaffold at an air-liquid interface. A titanium implant was inserted into the engineered oral mucosa and further cultured to establish epithelial attachment. The 3D OMM was characterized using basic histology and immunostaining for cytokeratin (CK) 10 and CK13. Histomorphometric analyses of the implant-soft tissue interface were carried out using a light-microscopy (LM) examination of ground sections and semi-thin sections as well as scanning electron microscopy (SEM). RESULTS: Immunohistochemistry analyses suggests that the engineered oral mucosa closely resembles the normal oral mucosa. The LM and SEM examinations reveal that the 3D OMM forms an epithelial attachment on the titanium surface. CONCLUSION: The 3D OMM provided mimicking peri-implant features as seen in an in vivo model and has the potential to be used as a relevant alternative model to assess implant-soft tissue interactions.
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| 5. |
- Dierens, Melissa, et al.
(författare)
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Long-Term Follow-Up of Turned Single Implants Placed in Periodontally Healthy Patients After 16 to 22 Years : Microbiologic Outcome
- 2013
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Ingår i: Journal of Periodontology. - : Amer Acad Periodontology. - 0022-3492 .- 1943-3670. ; 84:7, s. 880-894
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Tidskriftsartikel (refereegranskat)abstract
- Background: Survival rates in implant dentistry today are high, although late failures do occur for many reasons, including peri-implant infections. The primary objective of this study is to investigate microbiota around single turned implants after 16 to 22 years. Secondary objectives are to compare teeth and implants and to correlate microbiologic, radiographic, and clinical parameters. Methods: A total of 46 patients with single implants were invited for a clinical examination. Clinical datawere collected from implants and contralateral natural teeth. Radiographic bone level was measured around implants. Microbiologic samples were taken from implants, contralateral teeth, and the deepest pocket per quadrant. Samples were analyzed with DNA-DNA hybridization including 40 species. Statistical analysis was performed using Wilcoxon signed-rank tests, McNemar tests, and Spearman correlation coefficients with a 0.05 significance level. Results: Mean follow-up was 18.5 years (range 16 to 22 years). Tannerella forsythia (1.5 x 10(5)) and Veillonella parvula (1.02 x 10(5)) showed the highest concentrations around implants and teeth, respectively. Porphyromonas gingivalis, Prevotella intermedia, and T. forsythia were significantly more present around implants than teeth. Mean counts were significantly higher around implants than teeth for Parvimonas micra, P. gingivalis, P. intermedia, T. forsythia, and Treponema denticola. Total DNA count was correlated to interproximal bleeding index (r = 0.409) and interproximal probing depth (r = 0.307). No correlations were present with plaque index or radiographic bone level. Conclusions: In the present study, bacterial counts around single implants in periodontally healthy patients are rather low. Although pathogenic bacteria are present, some in higher numbers around implants than teeth (five of 40), the majority of implants present with healthy peri-implant tissues without progressive bone loss.
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| 6. |
- Döös, Kristofer, et al.
(författare)
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The world ocean thermohaline circulation
- 2012
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Ingår i: Journal of Physical Oceanography. - 0022-3670 .- 1520-0485. ; 42:9, s. 1445-1460
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Tidskriftsartikel (refereegranskat)abstract
- A new global streamfunction is presented and denoted the thermohaline streamfunction. This is defined as the volume transport in terms of temperature and salinity (hence no spatial variables). The streamfunction is used to analyze and quantify the entire World Ocean conversion rate between cold/warm and fresh/saline waters. It captures two main cells of the global thermohaline circulation, one corresponding to the conveyor belt and one corresponding to the shallow tropical circulation. The definition of a thermohaline streamfunction also enables a new method of estimating the turnover time as well as the heat and freshwater transports of the conveyor belt. The overturning time of the conveyor belt is estimated to be between 1000 and 2000 yr, depending on the choice of stream layer. The heat and freshwater transports of these two large thermohaline cells have been calculated by integrating the thermohaline streamfunction over the salinity or temperature, yielding a maximum heat transport of the conveyor belt of 1.2 PW over the 34.2-PSU salinity surface and a freshwater transport of 0.8 Sv (1 Sv = 10(6) m(3) s(-1)) over the 9 degrees C isotherm. This is a measure of the net interocean exchange of heat between the Atlantic and Indo-Pacific due to the thermohaline circulation.
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| 7. |
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| 8. |
- Fadel, Hani T, 1979, et al.
(författare)
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Caries risk and periodontitis in patients with coronary artery disease.
- 2011
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Ingår i: Journal of periodontology. - : Wiley. - 1943-3670 .- 0022-3492. ; 82:9, s. 1295-303
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Tidskriftsartikel (refereegranskat)abstract
- ACKGROUND: There is considerable variation in studies on the oral health of patients with coronary artery disease (CAD). The aims of this investigation are to study the caries risk profile using the Cariogram computer program and the periodontal disease severity in patients with CAD. METHODS: A total of 127 participants (54 test and 73 control) were included. Participants were asked about their general health and daily habits. Clinical examinations, radiographs, and salivary sampling were performed. Cariologic data were entered into the computer program for risk-profile illustration. The onset of CAD conditions was also documented. RESULTS: Compared with controls, participants with CAD consumed less sugar, used fluoride toothpaste less frequently, and had significantly less favorable periodontal parameters (P <0.005). Generally, differences in cariologic parameters between the two groups were not significant. Significantly more participants with CAD exhibited low salivary-secretion rates than controls. The actual chance (percentage) of avoiding new cavities according to the Cariogram was low in the test and control groups (31% and 40%, respectively; P <0.05). Only gingival recession was correlated with the onset of CAD. CONCLUSIONS: Test and control groups had a relatively high caries risk. More severe periodontal disease was observed in participants with CAD.
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| 9. |
- Fadel, Hani T, 1979, et al.
(författare)
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Profiles of Dental Caries and Periodontal Disease in Individuals With or Without Psoriasis.
- 2013
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Ingår i: Journal of periodontology. - : Wiley. - 1943-3670 .- 0022-3492. ; 84:4, s. 477-485
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Tidskriftsartikel (refereegranskat)abstract
- Background: Psoriasis is a chronic inflammatory skin disease. Studies of oral health in psoriasis patients are limited. The aim was to assess the experience and risk of caries and periodontal disease in psoriatics and non-psoriatics. Material and Methods: The material consisted of 89 individuals with mild to moderate chronic plaque psoriasis and 54 non-psoriatics, recruited at the University Hospital in Gothenburg. Psoriasis arthritis was diagnosed in 25 of the psoriatics. All participants answered questionnaires and were subjected to saliva sampling and oral radiological and clinical examinations. Two computer applications were used for illustration of oral disease risk profiles. Results: Psoriatics had lower salivary pH, fewer remaining teeth, fewer sites with probing pocket depth ≤4 mm and a lower radiographic alveolar bone level than non-psoriatics (p<0.05). Most of the differences remained significant after controlling for confounders. Differences in alveolar bone levels were no longer significant, particularly after introducing "gender" into the regression model. Similar numbers of decayed and filled teeth, sites with deep pockets, sites that bled on probing and risk profiles were observed. Individuals with psoriasis arthritis exhibited a lower stimulated salivary secretion rate than non-psoriatics (p<0.05). Conclusions: There were no differences in profiles of caries and periodontal disease experience and risk between individuals with and without psoriasis. Fewer remaining teeth were observed in psoriatics. However, the exact reason for tooth loss could not be identified. Meanwhile, the reduced salivary pH in psoriatics and salivary secretion in psoriasis arthritis individuals, may pose a risk for future caries.
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| 10. |
- Falahat, Saeed, et al.
(författare)
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Global Calculation of Tidal Energy Conversion into Vertical Normal Modes
- 2014
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Ingår i: Journal of Physical Oceanography. - 0022-3670 .- 1520-0485. ; 44:12, s. 3225-3244
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Tidskriftsartikel (refereegranskat)abstract
- A direct calculation of the tidal generation of internal waves over the global ocean is presented. The calculation is based on a semianalytical model, assuming that the internal tide characteristic slope exceeds the bathymetric slope (subcritical slope) and the bathymetric height is small relative to the vertical scale of the wave, as well as that the horizontal tidal excursion is smaller than the horizontal topographic scale. The calculation is performed for the M-2 tidal constituent. In contrast to previous similar computations, the internal tide is projected onto vertical eigenmodes, which gives two advantages. First, the vertical density profile and the finite ocean depth are taken into account in a fully consistent way, in contrast to earlier work based on the WKB approximation. Nevertheless, the WKB-based total global conversion follows closely that obtained using the eigenmode decomposition in each of the latitudinal and vertical distributions. Second, the information about the distribution of the conversion energy over different vertical modes is valuable, since the lowest modes can propagate over long distances, while high modes are more likely to dissipate locally, near the generation site. It is found that the difference between the vertical distributions of the tidal conversion into the vertical modes is smaller for the case of very deep ocean than the shallow-ocean depth. The results of the present work pave the way for future work on the vertical and horizontal distribution of the mixing caused by internal tides.
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