The effect of pilocarpine, oxotremorine and arecoline in combination with methyl-atropine or atropine on hormone activated oestrous behaviour in ovariectomized rats

• The effects of pilocarpine, oxotremorine and arecoline were studied on oestradiol/progesterone activated oestrous behaviour in ovariectomized rats. A heat-inhibitory effect was obtained, which could be more effectively counteracted by atrophie than methyl-atropine.No positive correlation was seen between the inhibitory effect on oestrous behaviour and the ability of the different cholinergic compounds to induce tremor or decrease the locomotor activity.The data indicate that in addition to earlier described monoaminergic pathways mediating inhibition of oestrous behaviour, cholinergic mechanisms are also involved.The results of this study were presented in part at the XII Scandinavian Congress of Physiology 1966 at Turku, Finland.

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