| 1. |
|
|
| 2. |
|
|
| 3. |
- Irani, Mudar Zand, et al.
(författare)
-
Neutrophils, eosinophils, and intraepithelial lymphocytes in the squamous esophagus in subjects with and without gastroesophageal reflux symptoms
- 2021
-
Ingår i: Human Pathology. - : Elsevier BV. - 0046-8177 .- 1532-8392. ; 115, s. 112-122
-
Tidskriftsartikel (refereegranskat)abstract
- Whilst intraepithelial lymphocytes (IELs) are considered normal within the distal esophageal mucosa, they have an increasingly recognised role in the pathogenesis of reflux esophagitis, and IEL quantification establishes the diagnosis of lymphocytic esophagitis. Knowledge regarding the upper limit of a normal IEL count in health is lacking. We studied 117 non-healthcare seeking adult volunteers from a random community sample (the Kalixanda study) with esophageal biopsies 2 cm above the gastroesophageal junction. Subjects were divided into four groups based on the presence or absence of gastro-esophageal reflux symptoms and/or esophagitis on endoscopy. Asymptomatic subjects with no endoscopic esophagitis were selected as controls, and the cell counts in this group were used to define the upper limit of normal of IELs, eosinophils and neutrophils. The entire sample was used to identify independent predictors of increased cellular counts by logistic regression analysis. None of the healthy controls had an IEL count of more than three per five high power fields (HPF), and therefore this was considered as the upper limit of normal; no controls had eosinophils or neutrophils in esophageal biopsies. Independent predictors of an elevated IEL count were spongiosis on histology (OR 11.17, 95% CI 3.32–37.58, P < 0.01) and current smoking (OR 4.84, 95% CI 1.13–2.71, P = 0.03). A receiver operating characteristics analysis concluded that a threshold of 3 IELs/5HPFs performs best in predicting reflux symptoms when a normal esophageal mucosa is visualized on endoscopy (sensitivity = 100.0%, specificity = 35.2%). The healthy esophageal mucosa does not contain more than three IELs per five HPF in the distal esophagus.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Abdi, Saida, et al.
(författare)
-
Promoting positive development among refugee adolescents
- 2023
-
Ingår i: Journal of research on adolescence. - : John Wiley & Sons. - 1050-8392 .- 1532-7795. ; 33:4, s. 1064-1084
-
Forskningsöversikt (refereegranskat)abstract
- Of the estimated 35.3 million refugees around the world (UNHCR, Figures at a Glance, 2022), approximately 50% are children under the age of 18. Refugee adolescents represent a unique group as they navigate developmental tasks in an unstable and often threatening environment or in resettlement contexts in which they often face marginalization. In addition to physiological, social, and psychological changes that mark adolescence, refugee youth often face traumatic experiences, acculturative stress, discrimination, and a lack of basic resources. In this consensus statement, we examine research on refugee adolescents' developmental tasks, acculturative tasks, and psychological adjustment using Suarez-Orozco and colleague's integrative risk and resilience model for immigrant-origin children and youth proposed by Suarez-Orozco et al. Finally, we discuss recommendations-moving from proximal to more distal contexts.
|
|
| 7. |
- Bernardo, Carina, et al.
(författare)
-
Molecular pathology of the non-luminal Ba/Sq-like and Sc/NE-like classes of urothelial tumours : An integrated immunohistochemical analysis
- 2022
-
Ingår i: Human Pathology. - : Elsevier BV. - 0046-8177. ; 122, s. 11-24
-
Tidskriftsartikel (refereegranskat)abstract
- Several groups have during past years produced molecular classification schemes for bladder cancer. Even though no consensus on how to define a subtype exists, one approach has been to base definitions on how tumours cluster according to their mRNA expression profiles. In many cases, obtained profiles, and thus class defining features, are affected by signals from non-tumour cells within the biopsy. To overcome this issue, we combined gene expression analyses with analyses of the actual tumour cells by extensive immunohistochemistry (IHC). By this approach we were able to define tumour cell phenotypes i.e., subtypes defined by features of the tumour cells only, and adjust mRNA-based algorithms accordingly. In the present investigation we address the non-luminal Basal/Squamous-like (Ba/Sq) and Small cell/Neuroendocrine-like (Sc/NE) categories of tumours defined by mRNA-based classification. We make use of IHC data for 15 proteins, all known to be instrumental for defining molecular subtypes of urothelial carcinoma. We show that the UroB type of tumours, frequently grouped together with Ba/Sq, are different from the Ba/Sq entity at several essential features and is a derivative of Urothelial-like tumours (Uro). We show that the Sc/NE tumours are similar to but represents extreme versions of Genomically Unstable (GU) tumours. We apply clustering to 423 cases representing all subtypes using IHC data for 14 proteins and show that the obtained grouping conforms well with the mRNA-based classification. This work describes in detail the molecular pathology of non-luminal RNA-based bladder cancer subtypes and highlight similarities/dissimilarities suggestive of origin.
|
|
| 8. |
|
|
| 9. |
- Kapetanovic, Sabina, 1980-, et al.
(författare)
-
Does one Size Fit All? : Linking Parenting With Adolescent Substance Use and Adolescent Temperament
- 2020
-
Ingår i: Journal of research on adolescence. - : Wiley. - 1050-8392 .- 1532-7795. ; 30:suppl 2, s. 443-457
-
Tidskriftsartikel (refereegranskat)abstract
- Using longitudinal Swedish data from 1,373 early‐adolescent youths, this study aims to answer the question of whether the previously established protective function of parental knowledge and its sources — adolescent disclosure, parental solicitation, and parental control—on substance use among early‐adolescents is moderated by the adolescent's temperament. Adolescent temperament moderated several links between parental knowledge and its sources and adolescent substance use. The most pronounced moderating results were found for those adolescents with fearless, socially detached and thrill‐seeking tendencies. For these "detached thrill‐seekers", bidirectional links between adolescent disclosure and substance use, and negative links between parental solicitation and substance use were found. We recommend, therefore, that adolescent temperament is considered when designing parenting programs.
|
|
| 10. |
- Lunde, Carolina, et al.
(författare)
-
Being Under Pressure to Sext: Adolescents' Experiences, Reactions, and Counter-Strategies
- 2023
-
Ingår i: Journal of Research on Adolescence. - : Wiley. - 1050-8392 .- 1532-7795. ; 33:1, s. 188-201
-
Tidskriftsartikel (refereegranskat)abstract
- This study explored adolescents' experiences of being under pressure to sext (sending nude images), offering insights into what situations adolescents view as pressuring, how adolescents react to the pressure, and what counter-strategies they use. Written statements from 225 adolescents (age 13–16 years, M = 14.4 years, SD = 0.93) were analyzed using thematic analysis. Results indicated a range of situations including both explicit and implicit pressure. The pressure elicited different emotional responses, including severe physical and psychological reactions, becoming distressed, and being seemingly unconcerned. A majority of the adolescents reported successful strategies on how to ward off the unwanted sexual requests. This study provides insight into how young people cope with potentially harmful situations online.
|
|
