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Träfflista för sökning "L773:0165 8107 OR L773:1744 506X srt2:(2020-2022)"

Sökning: L773:0165 8107 OR L773:1744 506X > (2020-2022)

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1.
  • Bro, Tomas, et al. (författare)
  • The Effects of Visual Field Loss from Optic Disc Drusen on Performance in a Driving Simulator
  • 2022
  • Ingår i: Neuro-ophthalmology (Aeolus Press. 1980). - : TAYLOR & FRANCIS AS. - 0165-8107 .- 1744-506X.
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this study was to compare the driving simulator performance of participants with visual field loss (VFL) from optic disc drusen (ODD) with a normally sighted control group and a group of individuals with glaucoma. Data on performance and safety from a traffic simulator test for five participants with VFL from ODD were retrospectively compared with data from 49 male individuals without visual deficits in a cross-sectional study. VFL of the ODD group was also compared with a group of 20 male glaucoma participants who had failed the same simulator test. Four individuals with ODD regained their driving licences after a successful simulator test and were then followed in a national accident database. All participants with ODD passed the test. No significant differences in safety or performance measures were detected between the normally sighted participants and the ODD group despite severe concentric visual field constrictions. Compared with failed glaucoma male participants, the ODD group had even lower mean sensitivity in the peripheral and peripheral inferior field of vision. None of the four participants with a regained licence were involved in a motor vehicle accident during a 3-year follow-up period after the simulator test. Despite having severe VFL, participants with ODD had no worse performance or safety than controls. As even individuals with severe VFL might drive safely, there is a need for individual practical assessments on licencing issues.
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2.
  • Weissert, Robert, et al. (författare)
  • Upregulated Retinal Neurofilament Expression in Experimental Optic Neuritis
  • 2022
  • Ingår i: Neuro-Ophthalmology. - : Informa UK Limited. - 0165-8107 .- 1744-506X. ; 46:4, s. 215-219
  • Tidskriftsartikel (refereegranskat)abstract
    • In optic neuritis (ON), transient thickening of the macular retinal nerve fibre layer (RNFL) can be observed. This optical coherence tomography-based observation is not understood. The axonal diameter correlates with the neurofilament (Nf) protein content, but there are no data on the retinal tissue concentration of Nfs. The myelin-oligodendrocyte-glycoprotein (MOG) induced experimental autoimmune encephalomyelitis (EAE) model was used to investigate the retinas of Brown Norway rats with (i) visual evoked potentials (VEP) confirmed ON, (ii) VEP confirmed absence of ON and (iii) control animals. Twenty retinas were collected from MOG-EAE and control rats 27 days after immunisation. Retinal tissue Nf concentrations per total protein (μg/mg) were significantly higher in MOG-EAE rats with ON (median 4.29, interquartile range [IQR] 3.41–5.97) compared with MOG-EAE rats without ON (1.14, IQR 1.10–1.67) or control rats (0.93, IQR 0.45–4.00). The data suggest that up-regulation of Nf expression in the retinal ganglion cells precedes development of RNFL atrophy and plausibly explains the transient increase of axonal diameter and RNFL thickening.
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