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Träfflista för sökning "L773:0204 3564 OR L773:1812 9269 srt2:(2002-2004)"

Sökning: L773:0204 3564 OR L773:1812 9269 > (2002-2004)

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  • Philchenkov, A., et al. (författare)
  • Caspases and cancer : Mechanisms of inactivation and new treatment modalities
  • 2004
  • Ingår i: Experimental Oncology. - 0204-3564. ; 26:2, s. 82-97
  • Tidskriftsartikel (refereegranskat)abstract
    • Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis. Deregulation of apoptotic signaling pathways may contribute to oncogenesis. Aspartate specific cysteine proteases, termed caspases are the key effector molecules in apoptosis. The aim of this review is to summarize the various defects in caspase-dependent cell death machinery identified in the neoplastic cells. These include not only mutations, but also alterations of gene methylation, and altered mRNA stability. Among the molecules that we discuss are elements of the extrinsic death pathway like CD95 (APO-1/Fas), FADD, FLIPs, FLICE, other apical caspases, components of the intrinsic apoptotic pathway like Apaf-1, caspase-9, and modulators of apoptotic pathways like IAPs, Smac/DIABLO, OMI/HtrA2, and other apoptosis regulating proteins. We also discuss recent data on cancer-specific agents that target effector mechanisms of apoptosis. Particular emphasis is given to the prospects for combining cell suicide-activating approaches with classical cancer therapies.
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  • Souchelnytskyi, Serhiy (författare)
  • Transforming growth factor-beta signaling and its role in cancer
  • 2002
  • Ingår i: Experimental Oncology. - 0204-3564. ; 24:1, s. 3-12
  • Forskningsöversikt (populärvet., debatt m.m.)abstract
    • Transforming growth factor-b (TGFb) is a polypeptide growth factor, which regulates cell proliferation, differentiation, migration and apoptosis. During the last decade an exploration of mechanisms of TGFb receptor activation and discovery of Smads has stimulated significant progress in decoding of intracellular signaling of TGFb. These advancements request a re-evaluation of role of TGFb in human diseases. This review discusses recent achievements in understanding of the mechanisms governing TGFb signaling, with emphasis on overview of the role of TGFb in tumorigenesis.
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  • Resultat 1-6 av 6

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