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- Sohlstrom, A, et al.
(författare)
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Triglyceride turnover, lipoprotein lipase activity, and fat cell size in adipose tissue of rats during the first 2 weeks of pregnancy
- 1998
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Ingår i: Annals of nutrition & metabolism. - : S. Karger AG. - 0250-6807 .- 1421-9697. ; 42:1, s. 55-62
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Tidskriftsartikel (refereegranskat)abstract
- Understanding the biological function of the fat retained during pregnancy is important when estimating energy needs during reproduction. Women as well as rats are often considered to gain fat at specific anatomical sites during pregnancy and use this fat as a source of energy during lactation. However, mobilized body fat covers only a minor part of the energy needed by the lactating rat dam. In this paper, fat cell size, lipoprotein lipase activity, as well as triglyceride turnover in parametrial and subcutaneous adipose tissues were studied during the first 2 weeks of gestation and in virginal controls to further explore the metabolic and physiological basis for changes in body fat during reproduction in rats. Pregnancy increased the size of parametrial but not of subcutaneous adipocytes. The lipoprotein lipase activity in subcutaneous adipocytes was not increased by pregnancy. The accumulation in adipose tissue of <sup>14</sup>C from orally administered <sup>14</sup>C-oleic acid was higher in virginal than in pregnant rats. No effect of pregnancy on the rate of lipid turnover in parametrial or subcutaneous adipocytes was found. The findings are in accordance with the contention that body fat gained during rat pregnancy, to a large extent, is a consequence of a general growth of maternal tissues rather than the result of a stimulating effect of pregnancy on fat accumulation by adipocytes from specific body sites.
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| 2. |
- Önning, Gunilla, et al.
(författare)
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Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia
- 1999
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Ingår i: Annals of Nutrition and Metabolism. - : S. Karger AG. - 0250-6807 .- 1421-9697. ; 43:5, s. 301-309
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate whether consumption of a newly developed oat milk deprived of insoluble fiber would result in lower serum cholesterol and low-density lipoprotein (LDL) cholesterol levels in men with moderate hypercholesterolemia. The study had a randomized, controlled double-blind design, and oat milk was compared with an identically flavored control drink. Sixty-six men were recruited from a screening program and were randomly assigned to two groups. Each group took either oat milk or a control drink (rice milk) for 5 weeks (0.75 liters/day) and then switched to the other drink regimen for another 5-week period with a 5-week washout period between the test periods. The oat milk contained more dietary fiber, especially β-glucan (0.5 g/100 g), than the control drink (< 0.02 g/100 g). Both drinks were well appreciated and got similar sensory evaluation, indicating that the double-blind design had been attained. In the final analysis 52 subjects remained. Compared with the control drink, intake of oat milk resulted in significantly lower serum total cholesterol (6, p = 0.005) and LDL cholesterol (6, p = 0.036) levels. The decrease in LDL cholesterol was more pronounced if the starting value was higher (r = -0.55, p < 0.001). The concentration of high-density lipoprotein cholesterol was not significantly different after consumption of the two drinks. Serum triglycerides did not change significantly after intake of oat milk, but a significant increase was observed after intake of the control drink (p = 0.003). It is concluded that also oat milk deprived of insoluble fiber has cholesterol-reducing properties. Copyright (C) 2000 S. Karger AG, Basel.
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