| 1. |
- Atashipour, Rasoul, 1983, et al.
(författare)
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On buckling of layered composite heavy columns—Effect of interlayer bonding imperfection
- 2023
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Ingår i: International Journal of Solids and Structures. - : Elsevier BV. - 0020-7683 .- 1879-2146. ; 260-261
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Tidskriftsartikel (refereegranskat)abstract
- Buckling loads of partial composite columns under distributed axial loads is investigated in this paper for the first time. The interlayer interaction corresponding to the level of interfacial bonding imperfection in the layered heavy composite columns is formulated in the model by a shear slip/stiffness modulus. Governing differential equations and boundary equations are derived and represented in a general dimensionless form. A semi-analytical solution is applied to the governing buckling equations of the presented model using power-series technique to extract critical loads of partial composite columns. Five different classical end types are considered namely clamped–clamped (C-C), clamped-pinned (C-P), clamped-sliding (C-S), clamped-free (C-F) and pinned–pinned (P-P). Also, for two extreme cases of non-composite/zero-interaction and full-composite/perfectly-bonded layered columns, exact closed-form characteristic buckling equations are introduced. A convergence study is conducted to ensure stability of the applied power-series solution. It is demonstrated that the obtained buckling loads for partial composite columns with different end conditions approach those obtained from the exact closed-from solution for the full-composite extreme case when the interfacial shear modulus approaches infinity. Effect of imperfect bonding between the column layers and slip on critical buckling loads is investigated. It is shown that a more realistic model based on the partial composite interaction hypothesis predicts critical loads that are less than those based on idealized composite columns with perfect interfacial bonding.
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| 2. |
- Brown, A. Kyle, et al.
(författare)
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Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model
- 2021
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Ingår i: Life Sciences. - : Elsevier. - 0024-3205 .- 1879-0631. ; 279
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The present study investigated if treatment with the immunotherapeutic, lacto-N-fucopentaose-III (LNFPIII), resulted in amelioration of acute and persisting deficits in synaptic plasticity and transmission as well as trophic factor expression along the hippocampal dorsoventral axis in a mouse model of Gulf War Illness (GWI).Main methods: Mice received either coadministered or delayed LNFPIII treatment throughout or following, respectively, exposure to a 15-day GWI induction paradigm. Subsets of animals were subsequently sacrificed 48 h, seven months, or 11 months post GWI-related (GWIR) exposure for hippocampal qPCR or in vitro electrophysiology experiments.Key findings: Progressively worsened impairments in hippocampal synaptic plasticity, as well as a biphasic effect on hippocampal synaptic transmission, were detected in GWIR-exposed animals. Dorsoventral-specific impairments in hippocampal synaptic responses became more pronounced over time, particularly in the dorsal hippocampus. Notably, delayed LNFPIII treatment ameliorated GWI-related aberrations in hippocampal synaptic plasticity and transmission seven and 11 months post-exposure, an effect that was consistent with enhanced hippocampal trophic factor expression and absence of increased interleukin 6 (IL-6) in animals treated with LNFPIII.Significance: Approximately a third of Gulf War Veterans have GWI; however, GWI therapeutics are presently limited to targeted and symptomatic treatments. As increasing evidence underscores the substantial role of persisting neuroimmune dysfunction in GWI, efficacious neuroactive immunotherapeutics hold substantial promise in yielding GWI remission. The findings in the present report indicate that LNFPIII may be an efficacious candidate for ameliorating persisting neurological abnormalities presented in GWI.
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| 3. |
- Gripe, Isabella, et al.
(författare)
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Associations Between Cannabis Use and Mental Distress in Young People: A Longitudinal Study
- 2023
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Ingår i: Journal of Adolescent Health. - 1054-139X .- 1879-1972.
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Tidskriftsartikel (refereegranskat)abstract
- PurposeDespite a large number of studies on the relation between cannabis use and mental distress in adolescence, results are inconclusive regarding the nature of this association. The aim of the present study is to expand this body of research by analyzing the within-person association between changes in cannabis use and changes in mental distress among young people.MethodsWe used longitudinal data from a national sample of young people in Norway. The cohort was assessed in 1992 (T1), 1994 (T2), 1999 (T3), and 2005 (T4). The cumulative response rate was 60%. Respondents who participated in all four waves, aged 11–18 years at T1 (N = 1,988) were analyzed. Within-person association between changes in cannabis use and changes in mental distress in terms of symptoms of depression, anxiety, suicidal ideation, and deliberate self-harm were estimated by applying fixed-effects modeling.ResultsFor males, an increase in cannabis use from no use to more than 10 times/year was significantly associated with increased risk for anxiety (relative risk [RR]: 1.72, p = .009), depressed mood (RR: 1.49, p < .001), and suicidal ideation (RR: 3.43, p = .012). For females, the corresponding increase in cannabis use yielded an increased risk for anxiety (RR: 1.38, p = .023) and suicidal ideation (RR: 2.47, p = .002).DiscussionIncreased cannabis use during adolescence and young adulthood seem to increase the risk for symptoms of mental distress. Although the associations appear to be more pronounced among males, it was only for depression that there was a statistically significant gender difference in the association.
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| 4. |
- Hallingberg, Britt, et al.
(författare)
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Joint Family Activities and Adolescent Health and Wellbeing : Further Considerations Following the War in Ukraine
- 2022
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Ingår i: Journal of Adolescent Health. - : Elsevier BV. - 1054-139X .- 1879-1972. ; 71:1, s. 132-133
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Tidskriftsartikel (refereegranskat)abstract
- To the Editors:As the authors of the article, “Typologies of Joint Family Activities and Associations With Mental Health and Wellbeing Among Adolescents From Four Countries,” we would like to provide a statement in light of recent events taking place in Eastern Europe [1]. Following the tragic events surrounding the war in Ukraine which started on February 24, 2022, more than half the country’s 7.5 million children have now been displaced [2]. At the time of this paper’s acceptance, hundreds of thousands of refugees making up mostly women and children have travelled to Slovakia, Czechia, and even Russia [3]; countries of focus in the current study. Families have been separated, and the once familiar routines of school and leisure for many Ukrainian children have been replaced with ensuring survival coupled with trauma and unfamiliarity. Lack of housing, malnutrition/hunger, exposure to infectious disease but also deprivation of education, sport, and leisure, are just some of the devastating impacts from armed conflicts on young people’s health and wellbeing [4]. Families from Ukraine will add to the growing number of refugees in the world, a group of over 21 million people who can often struggle with sociocultural differences in the countries they take refuge, as well as accessing information due to language barriers [5]. Many of the most common family activities for the children in our study, such as eating a meal and talking together, will likely present differently or have very different meaning among the hundreds of children who have arrived and will continue to come to these countries. Similarly, the mental health and wellbeing of both those from Ukraine and those from countries geographically close to the conflict will almost certainly suffer following these terrible events. Júnior et al. [4] highlight the importance of addressing children’s psychosocial needs, recommending parents create a safe space that allows for listening to children. As demonstrated in our paper, spending time together with family is important for adolescent’s health wellbeing and may be particularly crucial for families affected by the crisis. We hope that future research surrounding leisure time use and adolescent health considers the needs of marginalized and vulnerable groups of young people in particular, such as those affected and displaced by war and conflict.
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| 5. |
- Hendriks, Kasper P., et al.
(författare)
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Global Brassicaceae phylogeny based on filtering of 1,000-gene dataset
- 2023
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Ingår i: Current Biology. - : Elsevier. - 0960-9822 .- 1879-0445. ; 33:19, s. 4052-4068
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Tidskriftsartikel (refereegranskat)abstract
- The mustard family (Brassicaceae) is a scientifically and economically important family, containing the model plant Arabidopsis thaliana and numerous crop species that feed billions worldwide. Despite its relevance, most phylogenetic trees of the family are incompletely sampled and often contain poorly supported branches. Here, we present the most complete Brassicaceae genus-level family phylogenies to date (Bras-sicaceae Tree of Life or BrassiToL) based on nuclear (1,081 genes, 319 of the 349 genera; 57 of the 58 tribes) and plastome (60 genes, 265 genera; all tribes) data. We found cytonuclear discordance between the two, which is likely a result of rampant hybridization among closely and more distantly related lineages. To eval-uate the impact of such hybridization on the nuclear phylogeny reconstruction, we performed five different gene sampling routines, which increasingly removed putatively paralog genes. Our cleaned subset of 297 genes revealed high support for the tribes, whereas support for the main lineages (supertribes) was moder-ate. Calibration based on the 20 most clock-like nuclear genes suggests a late Eocene to late Oligocene origin of the family. Finally, our results strongly support a recently published new family classification, dividing the family into two subfamilies (one with five supertribes), together representing 58 tribes. This includes five recently described or re-established tribes, including Arabidopsideae, a monogeneric tribe accommodating Arabidopsis without any close relatives. With a worldwide community of thousands of researchers working on Brassicaceae and its diverse members, our new genus-level family phylogeny will be an indispensable tool for studies on biodiversity and plant biology.
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| 6. |
- Kilbo Edlund, Karl, et al.
(författare)
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Long-term ambient air pollution and coronary atherosclerosis : results from the Swedish SCAPIS study
- 2024
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Ingår i: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484.
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Despite firm evidence for an association between long-term ambient air pollution exposure and cardiovascular morbidity and mortality, results from epidemiological studies on the association between air pollution exposure and atherosclerosis have not been consistent. We investigated associations between long-term low-level air pollution exposure and coronary atherosclerosis.Methods: We performed a cross-sectional analysis in the large Swedish CArdioPulmonary bioImaging Study (SCAPIS, n = 30 154), a random general population sample. Concentrations of total and locally emitted particulate matter <2.5 μm (PM2.5), <10 μm (PM10), and nitrogen oxides (NOx) at the residential address were modelled using high-resolution dispersion models. We estimated associations between air pollution exposures and segment involvement score (SIS), coronary artery calcification score (CACS), number of non-calcified plaques (NCP), and number of significant stenoses, using ordinal regression models extensively adjusted for potential confounders.Results: Median 10-year average PM2.5 exposure was 6.2 μg/m3 (range 3.5–13.4 μg/m3). 51 % of participants were women and 51 % were never-smokers. None of the assessed pollutants were associated with a higher SIS or CACS. Exposure to PM2.5 was associated with NCP (adjusted OR 1.34, 95 % CI 1.13, 1.58, per 2.05 μg/m3). Associations with significant stenoses were inconsistent.Conclusions: In this large, middle-aged general population sample with low exposure levels, air pollution was not associated with measures of total burden of coronary atherosclerosis. However, PM2.5 appeared to be associated with a higher prevalence of non-calcified plaques. The results suggest that increased risk of early-stage atherosclerosis or rupture, but not increased total atherosclerotic burden, may be a pathway for long-term air pollution effects on cardiovascular disease.
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| 7. |
- Kilbo Edlund, Karl, et al.
(författare)
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Long-term ambient air pollution and coronary atherosclerosis: Results from the Swedish SCAPIS study.
- 2024
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Ingår i: Atherosclerosis. - 1879-1484.
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Tidskriftsartikel (refereegranskat)abstract
- Despite firm evidence for an association between long-term ambient air pollution exposure and cardiovascular morbidity and mortality, results from epidemiological studies on the association between air pollution exposure and atherosclerosis have not been consistent. We investigated associations between long-term low-level air pollution exposure and coronary atherosclerosis.We performed a cross-sectional analysis in the large Swedish CArdioPulmonary bioImaging Study (SCAPIS, n=30154), a random general population sample. Concentrations of total and locally emitted particulate matter <2.5μm (PM2.5), <10μm (PM10), and nitrogen oxides (NOx) at the residential address were modelled using high-resolution dispersion models. We estimated associations between air pollution exposures and segment involvement score (SIS), coronary artery calcification score (CACS), number of non-calcified plaques (NCP), and number of significant stenoses, using ordinal regression models extensively adjusted for potential confounders.Median 10-year average PM2.5 exposure was 6.2μg/m3 (range 3.5-13.4μg/m3). 51% of participants were women and 51% were never-smokers. None of the assessed pollutants were associated with a higher SIS or CACS. Exposure to PM2.5 was associated with NCP (adjusted OR 1.34, 95% CI 1.13, 1.58, per 2.05μg/m3). Associations with significant stenoses were inconsistent.In this large, middle-aged general population sample with low exposure levels, air pollution was not associated with measures of total burden of coronary atherosclerosis. However, PM2.5 appeared to be associated with a higher prevalence of non-calcified plaques. The results suggest that increased risk of early-stage atherosclerosis or rupture, but not increased total atherosclerotic burden, may be a pathway for long-term air pollution effects on cardiovascular disease.
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| 8. |
- Ortega, Jean C. G., et al.
(författare)
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Spatio-temporal variation in water beetle assemblages across temperate freshwater ecosystems
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 792
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Tidskriftsartikel (refereegranskat)abstract
- Ecological communities are structured by several mechanisms, including temporal, spatial and environmental factors. However, the simultaneous effects of these factors have rarely been studied. Here, we investigated their role on water beetle assemblages sampled over a period of 18 years. Water beetles were sampled in the spring of each year in lotic and lentic water bodies from mainland region of Kalmar and Oland Island in southeastern Sweden. We assessed how past assemblage structure, environmental factors and spatial variables correlated with current assemblage structure using a variation partitioning approach. We also tested for correlates of temporal beta diversity of water beetle assemblages with multiple regressions. We found that past water beetle assemblage structure explained current water beetle assemblage structure better than the environmental and spatial correlates. We also observed that temporal beta diversity of water beetle assemblages was mainly due to species gain rather than to species loss. Finally, environmental variables (e.g., hydroperiod, habitat size and hydrology) and timespan between sampling events explained part of temporal beta diversity and contribution of species loss to total assemblage dissimilarity variation. Despite the fact that most variation remained unexplained, we found that ecological factors that have been thought to be important for water beetle richness and abundance in past studies (e.g. water body size, water permanence, shore slope, and whether the water body is lentic or lotic) were also correlated to temporal beta diversity. From a conservation point of view, our study suggest that temporal variability of assemblage structure should be included in biological monitoring because of its potential to predict current assemblage structure. (c) 2021 Elsevier B.V. All rights reserved.
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| 9. |
- Parker, Kate, et al.
(författare)
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Typologies of Joint Family Activities and Associations With Mental Health and Wellbeing Among Adolescents From Four Countries
- 2022
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Ingår i: Journal of Adolescent Health. - : Elsevier BV. - 1054-139X .- 1879-1972. ; 71:1, s. 55-62
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: This study aims to identify distinct typologies of joint family activities and the associations with mental health and wellbeing among adolescents across four countries from the World Health Organization European region.Methods: The 2017/2018 data from adolescents from Armenia (n = 3,977, Mage = 13.5 ± 1.6 years, 53.4% female), Czechia (n = 10,656, Mage = 13.4 ± 1.7, 50.1% female), Russia (n = 4,096, Mage = 13.8 ± 1.7, 52.4% female), and Slovakia (n = 3,282, Mage = 13.4 ± 1.5, 51.0% female) were collected in schools. The respondents self-reported their participation in joint family leisure-time activities, life satisfaction, psychological and somatic complaints, as well as a range of demographic and family situational factors. Stratified by countries, latent class analysis identified typologies of joint family activities, and logistic regression models explored cross-sectional associations with life satisfaction, and psychological and somatic complaints.Results: Three typologies were identified across each of the four countries, distinguished by low, moderate, and high levels of family engagement. Adolescents with higher family engagement generally reported greater life satisfaction and fewer psychological complaints compared to those with lower family engagement. Russian adolescents in the high family engagement typology reported fewer somatic complaints compared to those with low family engagement. In addition, adolescents from Czechia and Russia showing moderate family engagement also reported fewer psychological complaints compared to those in the low family engagement typology. Discussion: Our findings from four countries suggest that adolescents with high family engagement have greater life satisfaction and fewer psychological complaints, pointing toward a need for interventions to support family engagement among adolescents. Further research is needed to fully explore underlying mechanisms.
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| 10. |
- Raninen, Jonas, et al.
(författare)
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Different measures of alcohol use as predictors of DSM-5 alcohol use disorder among adolescents – A cohort study from Sweden
- 2024
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Ingår i: Drug And Alcohol Dependence. - 0376-8716 .- 1879-0046.
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Tidskriftsartikel (refereegranskat)abstract
- Background and aimsThis study addresses a significant gap in existing research by investigating the longitudinal relationship between various measures of alcohol use and the development of alcohol use disorders (AUDs) in a cohort of Swedish adolescents.MethodsA prospective longitudinal survey was conducted on 3,999 adolescents in Sweden who were in 9th grade in 2017 and were followed up in 2019. Baseline assessments included lifetime alcohol use, recent use (past 30 days), risky drinking (AUDIT-C), and heavy episodic drinking (HED). Follow-up assessments comprised eleven items measuring DSM-5 AUD criteria. The study explores prospective associations between these diverse alcohol use measures and the occurrence of AUD, while also calculating population attributable fractions (PAF).FindingsThe proportion of drinkers who met the criteria for AUD at follow-up was 31.8%. All baseline measures of alcohol use exhibited associations with subsequent AUD. Notably, the HED group demonstrated the highest prevalence of AUD at 51.4% (p<.001). However, when calculating PAFs, any lifetime alcohol use emerged as the most substantial contributor, accounting for 10.8% of all subsequent AUD cases.ConclusionsThis study underscores that alcohol use during mid-adolescence heightens the risk of developing AUD in late adolescence. Among the various measures, heavy episodic drinking presents the highest risk for later AUD. From a public health perspective, preventing any alcohol use emerges as the most effective strategy to mitigate the population-level burden of AUD.
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