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Träfflista för sökning "L773:0301 0163 srt2:(1987-1989)"

Sökning: L773:0301 0163 > (1987-1989)

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1.
  • Lannering, Birgitta, 1948, et al. (författare)
  • Growth hormone release in children after cranial irradiation.
  • 1987
  • Ingår i: Hormone research. - 0301-0163. ; 27:1, s. 13-22
  • Tidskriftsartikel (refereegranskat)abstract
    • Growth retardation due to growth hormone (GH) deficiency is common in children after radiotherapy to the brain. Different methods for assessment of GH secretion were compared in 19 children who had received radiotherapy to the brain as part of treatment for a tumor of the brain, eye or epipharynx. GH was measured over a 24-hour period (72 sampling periods of 20 min each), as well as after administration of growth hormone-releasing hormone (GHRH) and arginine-insulin (AITT) tests. We found the 24-hour GH profile to be disturbed in all children; there was a low overall secretion with few peaks of low amplitude but a diurnal rhythm still discernable. In 16 children a prompt rise in GHRH after GHRH1-40 was seen indicating hypothalamic damage. The GH response after GHRH was not found to be correlated to the spontaneous secretion over 24 h. The results of the AITT showed discrepancies to the 24-hour GH profile in individual cases making this test unreliable in spite of a good overall correlation between the tests. Therefore, we suggest measurement of spontaneous secretion when GH-secretory capability is to be evaluated after cranial irradiation for a brain tumor.
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2.
  • Moëll, Christian, et al. (författare)
  • Blunted pubertal growth after leukemia: a new pattern of growth hormone insufficiency
  • 1988
  • Ingår i: Hormone Research. - 0301-0163. ; 30:2-3, s. 68-71
  • Tidskriftsartikel (refereegranskat)abstract
    • Growth, age at menarche and spontaneous GH secretion were studied in girls after treatment for acute lymphoblastic leukemia (ALL). These girls had normal prepubertal growth but subnormal pubertal growth. Mean final height was 1 SD less than expected before puberty. The average age at menarche was significantly lower than the normal mean for Swedish girls. The mean 24-hour GH secretion was severely blunted and there was no increase during puberty. We suggest that girls treated for ALL, including CNS irradiation, have a relative GH insufficiency which becomes clinically obvious only when the girls cannot respond to the increased demands for GH in puberty.
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