| 1. |
- Amin, Kawa, 1963-
(författare)
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The Role of the T lymphocytes and Remodeling in Asthma.
- 2016
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Ingår i: Inflammation. - : Springer Science and Business Media LLC. - 0360-3997 .- 1573-2576. ; 39:4, s. 1475-1482
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Tidskriftsartikel (refereegranskat)abstract
- In allergic asthma (AA), inflammatory changes in the airway epithelium may contribute to the characteristic pathophysiology and symptoms. The presence of T lymphocytes, eosinophils, mast cells and macrophages, the presence of cytokines, and also structural changes in the airway mucous membrane are characteristic for asthma. Bronchial biopsy specimens were obtained from 33 AA, 25 nonallergic asthma (NAA), and 20 healthy controls (HC). This study used immunohistochemical techniques for identified monoclonal antibodies (CD3, CD4, CD8, CD25, ECP, MBP, tenascin, and laminin) in the bronchi. The highest number of eosinophils and T lymphocyte cells in bronchial biopsies was found in AA, and NAA. The number of T lymphocytes in AA was significantly higher than in NAA and HC. The degree of epithelial damage was higher in the AA group compared to the other groups. The tenascin- and laminin-positive layers in AA were thicker than other groups. In AA, a significant negative correlation was found between epithelial integrity and the count for eosinophils or T lymphocytes. T lymphocytes and eosinophils in AA were found in the area of epithelial and lamina propria damage. This article suggests that T lymphocytes may not only contribute to the chronic airway inflammatory response, airway remodeling, and symptomatology but may also have a central role at the initiation of the allergic immune response. Th-targeted therapy would be of considerable interest in controlling AA. Having more knowledge on the roles of T lymphocytes in the pathogenesis of allergic inflammation highlights the contributions of these cells in regulating and may lead to a new therapeutic target-AA.
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| 2. |
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| 3. |
- Zhu, Bin, et al.
(författare)
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Apolipoprotein M Protects Against Lipopolysaccharide-Induced Acute Lung Injury via Sphingosine-1-Phosphate Signaling
- 2018
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Ingår i: Inflammation. - : Springer Science and Business Media LLC. - 0360-3997 .- 1573-2576. ; 41:2, s. 643-653
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: It had been demonstrated that apolipoprotein M (apoM) is an important carrier of sphingosine-1-phosphate (S1P) in blood, and the S1P has critical roles in the pathogenesis of sepsis-induced acute lung injury (ALI). In the present study, we investigated whether apoM has beneficial effects in a mouse model after lipopolysaccharide (LPS)-induced ALI. Forty-eight mice were divided into two groups: male C57BL/6 wild-type (apoM+/+) group (n = 24) and apoM gene-deficient (apoM−/−) group (n = 24) and then randomly subdivided into four subgroups (n = 6 each) according to different intraperitoneal (i.p.) injection: control group, W146 group, LPS group, and LPS + W146 group. Serum levels of interleukin-1 beta (IL-1β) and mRNA levels of IL-1β, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), lung histology, wet/dry weight ratio, and immunohistochemistry were measured at 3 h after the baseline and compared in each group. Our results clearly demonstrated that IL-1β mRNA levels and other inflammatory biomarkers were significantly increased in the lungs of LPS-induced ALI apoM−/− mice compared to those of the apoM+/+ mice. Moreover, when apoM+/+ mice were treated with W146, a S1P receptor (S1PR1) antagonist, these inflammatory biomarkers could be significantly upregulated by LPS-induced ALI. Therefore, it suggests that apoM-S1P-S1PR1 signaling might underlie the pathogenesis of ALI and apoM could have physiological benefits to alleviate LPS-induced ALI.
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| 4. |
- Åkerfeldt, Torbjörn, et al.
(författare)
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Postsurgical Acute Phase Reaction is Associated with Decreased Levels of Circulating Myostatin
- 2015
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Ingår i: Inflammation. - : Springer Science and Business Media LLC. - 0360-3997 .- 1573-2576. ; 38:4, s. 1727-1730
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Tidskriftsartikel (refereegranskat)abstract
- Muscle strength is of importance for postsurgical rehabilitation. Myostatin is a growth factor that regulates the size of muscles and could thus influence muscle mass and function in the postsurgical period. The aim of the present study was to study the changes in myostatin levels during the postsurgical inflammatory period. Myostatin was analysed in serum samples from two elective surgery groups, orthopaedic surgery (n = 24) and coronary bypass patients (n = 21). The samples were collected prior to surgery and 4 and 30 days after surgery. In the orthopaedic group, the median myostatin levels decreased from 3582 ng/L prior to surgery to 774 ng/L at day 4 (p < 0.001) and to 2016 ng/L at day 30 (p < 0.001). Median CRP increased from 2.35 mg/L preoperatively to 117 mg/L at day 4 and decreased to 5.5 mg/L at day 30 in the same group. The coronary bypass group showed a similar pattern with a decrease in myostatin from 4212 ng/L to 2574 ng/L at day 4 (p < 0.001) and to 2808 ng/L at day 30 (p = 0.002). Median CRP increased from 1.80 mg/L preoperatively to 136 mg/L at day 4 and returned to 6.12 mg/L at day 30 in the coronary bypass group. There was a significant decrease in myostatin concentrations both in the early and late postsurgical period. The lowest myostatin concentration time point coincided with the highest CRP concentration time point.
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| 5. |
- Harrand, Nicolas, et al.
(författare)
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A journey among Java neutral program variants
- 2019
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Ingår i: Genetic Programming and Evolvable Machines. - : Springer. - 1389-2576 .- 1573-7632. ; 20:4, s. 531-580
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Tidskriftsartikel (refereegranskat)abstract
- Neutral program variants are alternative implementations of a program, yet equivalent with respect to the test suite. Techniques such as approximate computing or genetic improvement share the intuition that potential for enhancements lies in these acceptable behavioral differences (e.g., enhanced performance or reliability). Yet, the automatic synthesis of neutral program variants, through program transformations remains a key challenge. This work aims at characterizing plastic code regions in Java programs, i.e., the code regions that are modifiable while maintaining functional correctness, according to a test suite. Our empirical study relies on automatic variations of 6 real-world Java programs. First, we transform these programs with three state-of-the-art program transformations: add, replace and delete statements. We get a pool of 23,445 neutral variants, from which we gather the following novel insights: developers naturally write code that supports fine-grain behavioral changes; statement deletion is a surprisingly effective program transformation; high-level design decisions, such as the choice of a data structure, are natural points that can evolve while keeping functionality. Second, we design 3 novel program transformations, targeted at specific plastic regions. New experiments reveal that respectively 60%, 58% and 73% of the synthesized variants (175,688 in total) are neutral and exhibit execution traces that are different from the original.
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