| 1. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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Chromosomal changes in rheumatoid arthritis patients treated with CPH82
- 1996
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Ingår i: Clinical Rheumatology. - 0770-3198 .- 1434-9949. ; 15:6, s. 584-589
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Tidskriftsartikel (refereegranskat)abstract
- Chromosomal changes were assessed in 19 patients with rheumatoid arthritis (RA) treated with CPH82, a benzylidated podophyllotoxin glycoside, for up to one ve:lr. The frequency of chromosomal aberrations (CA) and sister chromatid exchanges (SCE) in peripheral lymphocytes increased significantly after 12 weeks of treatment and remained elevated after 48 weeks treatment in peripheral lymphocytes. The number of CA and SCE were significantly increased in CPH82 treated patients compared with the RA patients treated with other disease modifying anti-rheumatic drugs (sulphasalazine, gold, D-penicillamine, azathioprine, methotrexate, cyclophosphamide). Only two patients treated with cyclophosphamide and azathioprine had changes of comparable levels, The results of this study suggest a mutagenic potential of CPH82 similar to that described for other immunosuppressive drugs and the newer podophyllotoxin derivatives, etoposide and teniposide.
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| 2. |
- Uddhammar, A, et al.
(författare)
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Peripheral-blood lymphocyte subsets in polymyalgia-rheumatica
- 1995
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Ingår i: Clinical Rheumatology. - 0770-3198 .- 1434-9949. ; 14, s. 62-67
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Tidskriftsartikel (refereegranskat)abstract
- Peripheral blood lymphocytes from 23 patients with polymyalgia rheumatica (PMR) were characterized using monoclonal antibodies and flow cytometry in a two-year prospective study. There were no significant differences in absolute numbers or relative percentages of lymphocytes or CD3+, CD4+, CD8+ T cells or the CD4+ T cell functional subsets, virgin (CD4+ CD45RA+) and memory (CD4+ CD29+) T cells, in patients before or during corticosteroid treatment compared to controls. Previous reports on decreased levels of CD8+ T cells as a characteristic of PMR/giant cell arteritis was not confirmed. The absolute number and relative percentage of lymphocytes with natural killer cell activity, CD16+ CD56+ cells, were significantly lower in patients with active untreated PMR as well as during corticosteriod treatment compared to controls, but at the two-year follow-up the difference was less marked.
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| 3. |
- Nordenskiöld, Ulla, 1935, et al.
(författare)
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Questionnaire to evaluate the effects of assistive devices and altered working methods in women with rheumatoid arthritis.
- 1998
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Ingår i: Clinical rheumatology. - 0770-3198. ; 17:1, s. 6-16
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Tidskriftsartikel (refereegranskat)abstract
- The objectives of the study were to identify perceived difficulty and reduction of difficulty when using assistive devices and altered working methods in performing daily activities and to detect which activities were unaffected by interventions. Twenty-one women aged 29-65 years with rheumatoid arthritis answered the Evaluation of Daily Activity Questionnaire (EDAQ), which contains 102 items divided into 11 dimensions of daily activities. The women rated their perceived difficulty twice: first when not using devices or altered methods and then when using them. The use of devices or altered methods led to a reduction in perceived difficulty in 42% of the ratings. The number of items that the women found difficult when not using devices/altered methods ranged between 13 and 99. With the interventions, the number of items still found difficult decreased to between 6 and 57, 91% of the devices provided were still in use. The dimensions Eating, Cooking and Toileting contained the most items affected by the use of devices such as lever taps, springy scissors, breadknife and wrist orthosis. Few effective devices were identified for the dimensions Dressing, Washing, Cleaning and Mobility Outdoors. It was concluded that the EDAQ represents a new approach to demonstrating difficulties in performing various daily activities, to describing the effects of assistive devices/altered methods, and to identifying areas not affected by interventions.
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