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Träfflista för sökning "L773:0887 4476 OR L773:1098 2396 srt2:(2005-2009)"

Sökning: L773:0887 4476 OR L773:1098 2396 > (2005-2009)

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  • Emilsson, Lina, et al. (författare)
  • Low mRNA levels of RGS4 splice variants in Alzheimer’s disease and association between a rare haplotype and decreased mRNA expression
  • 2006
  • Ingår i: Synapse. - 0887-4476 .- 1098-2396. ; 59:3, s. 173-176
  • Tidskriftsartikel (refereegranskat)abstract
    • Regulator of G-protein signaling 4 (RGS4) showed decreased mRNAlevels in Alzheimer’s disease in a large collection of human brain autopsies from prefrontalcortex. The expression levels of three RGS4 splice variants were examined inthe same samples, and the association between RGS4 gene expression and/or the diseasewith single nucleotide polymorphisms located in this gene was explored. We showthat all splice variants are down-regulated in patients. We also demonstrate that onerare haplotype (ATAG) is associated with decreased mRNA levels in both cases andcontrols. Our results suggest that an altered regulation in transcription initiation maybe an important mechanism for low RGS4 protein levels in Alzeimer’s disease.
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  • Henriksson, Richard, et al. (författare)
  • Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics
  • 2008
  • Ingår i: Synapse. - : Wiley. - 0887-4476 .- 1098-2396. ; 62:11, s. 829-33
  • Tidskriftsartikel (refereegranskat)abstract
    • Convergent lines of evidence suggest potentiation of glutamatergic synapses after chronic ethanol exposure, and indicate that the presynaptic effect hereof is on modulators of synaptic strength rather than on executors of glutamate release. To address this hypothesis in the context of ethanol dependence in humans, we used semiquantitative immunoblotting to compare the immunoreactivities of synaptophysin I, syntaxin 1A, synaptosome-associated protein 25, and vesicle-associated membrane protein in the prefrontal and motor cortices between chronic alcoholics and control subjects. We found a region-specific elevation in synaptophysin I immunoreactivity in the prefrontal cortex of alcoholics, but detected no significant differences between the groups in the immunoreactivities of the other three proteins. Our findings are consistent with an effect of repeated ethanol exposure on modulators of synaptic strength but not on executors of glutamate release, and suggest a role for synaptophysin I in the enduring neuroplasticity in the prefrontal cortical glutamate circuitry that is associated with ethanol dependence.
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  • Resultat 1-10 av 31

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