| 1. |
- Chrcanovic, Bruno, et al.
(författare)
-
Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?
- 2017
-
Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027 .- 1399-0020. ; 46:6, s. 782-788
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this retrospective study was to investigate the association between the intake of selective serotonin reuptake inhibitors (SSRIs) and the risk of dental implant failure. Patients were included if they were taking SSRIs only and no other medication, did not present any other systemic condition or compromising habits (bruxism, smoking, snuff), and complied with the use of prophylactic antibiotics for implant surgery. The multivariate generalized estimating equation (GEE) method and multilevel mixed-effects parametric survival analysis were used to test the association between SSRI exposure (predictor variable) and the risk of implant failure (outcome variable), adjusting for several potential confounders (other variables). The total number of implants with information available and meeting the necessary eligibility criteria was 931(35 failures). These were placed in 300 patients. The implant failure rate was 12.5% for SSRI users and 3.3% for nonusers (P = 0.007). Kaplan-Meier analysis showed a statistically significant difference in the cumulative survival rate (P < 0.001). The multivariate GEE model did not show a statistically significant association between SSRI intake and implant failure (P = 0.530), nor did the multilevel model (P = 0.125). It is suggested that the intake of SSRIs may not be associated with an increased risk of dental implant failure.
|
|
| 2. |
- Chrcanovic, Bruno, et al.
(författare)
-
Melanotic neuroectodermal tumour of infancy of the jaws : an analysis of diagnostic features and treatment
- 2019
-
Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier. - 0901-5027 .- 1399-0020. ; 48:1, s. 1-9
-
Forskningsöversikt (refereegranskat)abstract
- The purpose of this study was to integrate the available published data on melanotic neuroectodermal tumour of infancy (MNTI) of the jaws into a comprehensive analysis of its clinical/radiological features, with emphasis on the predictive factors associated with recurrence. Eligibility criteria included publications with sufficient clinical/radiological/histological information to confirm the diagnosis. A total of 288 publications reporting 429 MNTI cases were included. MNTIs were slightly more prevalent in males and markedly more prevalent in the maxilla. Most of the lesions were asymptomatic, presenting cortical bone perforation and tooth displacement. Nine lesions were malignant, with metastasis in five cases. Enucleation was the predominant treatment (67.2%), followed by marginal (18.4%) and segmental resection (6.1%). Eighty-one of 356 lesions (22.8%) recurred. Recurrence rates were 61.5% for curettage, 25.3% for enucleation alone, 16.2% for enucleation + curettage, 20.0% for enucleation + peripheral osteotomy, 11.3% for marginal resection, 10.0% for segmental resection, 30.0% for chemotherapy, and 33.3% for radiotherapy. Enucleation and resection presented significantly lower recurrence rates in comparison to curettage. Curettage appears not to be the best form of treatment, due to its high recurrence rate. As resection (either marginal or segmental) is associated with higher morbidity, enucleation with or without complementary treatment (curettage or peripheral osteotomy) would appear to be the most indicated therapy.
|
|
| 3. |
|
|
| 4. |
- Abtahi, Jahan, et al.
(författare)
-
Randomised trial of bisphosphonate-coated dental implants: Radiographic follow-up after five years of loading
- 2016
-
Ingår i: International Journal of Oral and Maxillofacial Surgery. - : CHURCHILL LIVINGSTONE. - 0901-5027 .- 1399-0020. ; 45:12, s. 1564-1569
-
Tidskriftsartikel (refereegranskat)abstract
- The results of a randomised trial with bisphosphonate-coated dental implants have been reported previously. Each patient received one coated and one uncoated implant in a double-blind split-mouth design study. After 6 months of osseointegration, resonance frequency analysis indicated better fixation of the coated implants. Reduced marginal bone resorption was also shown. However, it was not known whether the advantage of the bisphosphonate coating would persist over time. The radiographic results at 5 years after implant installation are reported herein. A blinded investigator measured marginal resorption on fresh radiographs obtained for 14 of the 16 patients (two had died) and compared these with the post-implantation images. Non-parametric statistics were used. All implants functioned well. The median marginal bone loss for control implants was found to be 0.70 mm, which is less than usually reported in the literature. The bisphosphonate-coated implants showed even less resorption (median 0.20 mm). The median difference within each pair of implants after 5 years of use was 0.34 mm (95% confidence interval 0.00-0.75 mm; P = 0.04). The present data suggest that bisphosphonate-coated implants enable prolonged preservation of the marginal bone.
|
|
| 5. |
- Alstad, V., et al.
(författare)
-
Surgical removal of keratocystic odontogenic tumours via a Le Fort I osteotomy approach: a retrospective study of the recurrence rate
- 2017
-
Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier. - 0901-5027 .- 1399-0020. ; 46:4, s. 434-439
-
Tidskriftsartikel (refereegranskat)abstract
- The keratocystic odontogenic tumour (KCOT) is one of the most aggressive odontogenic cysts and has a high recurrence rate. The treatment of these tumours is the subject of debate. A KCOT in the posterior maxilla with sinus involvement is rare. Few reports have been published in the literature. The purpose of this study was to evaluate the recurrence rate after surgical removal of maxillary KCOTs via a Le Fort I osteotomy. A search was performed to identify patients with a follow-up time of at least 5 years. Nine patients were included in the study. The following clinical variables were analyzed: age at surgery, sex, symptoms, site and size of the tumour, surgical approach, and recurrence rate. The surgical approaches were curettage (n=6) and enucleation (n=3). Recurrence was seen in three patients (33%); all had multilocular tumours. No recurrence was seen in patients with unilocular tumours. The Le Fort I osteotomy approach allows direct visualization and ensures wide excision, minimizing the risk of recurrence. In this series, cases with a multilocular KCOT showed a higher risk of recurrence due to the difficulty of removing the tumour in total. All recurrences took place within 2 years of the intervention; a 5-year follow-up is recommended.
|
|
| 6. |
- Chrcanovic, Bruno, et al.
(författare)
-
Gorham-Stout disease with involvement of the jaws : a systematic review
- 2019
-
Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier. - 0901-5027 .- 1399-0020. ; 48:8, s. 1015-1021
-
Forskningsöversikt (refereegranskat)abstract
- The purpose was to systematically review all published cases of Gorham-Stout disease (GSD) involving the jaws, identify the clinic-radiological and histopathological features associated with the persistence of the lesions, and the best treatment options available. An electronic search was undertaken in November/2018. Eligibility criteria included publications having enough information to confirm the diagnosis. Eighty-six publications reporting 89 cases were included. Features observed: symptomatic (51.1%), swelling (34.1%), pathological fracture (31.8%), history of previous trauma (32.1%), high levels of alkaline phosphatase (24.3%), predominance of vascular tissue (72.4%). Nearly 1/4 of the patients were only followed up and no treatment was implemented. Most of treatments consisted of some type of surgery with/without additional therapies (42.0%), drugs (20.5%), and radiotherapy (14.8%). Half of the cases were found to persist after some treatment modality and five patients died. Among the different variables investigated, only the fact of crossing the midline showed association with the persistence of the lesion. There is still a lot to understand about GSD, a rare condition with no clear consensus on the etiopathology, unpredictable clinical course, and no standard treatment. The high percentage of cases that persist after treatment are found to be associated only with the lesion crossing the midline.
|
|
| 7. |
- Chrcanovic, Bruno, et al.
(författare)
-
Idiopathic bone cavity of the jaws : an updated analysis of the cases reported in the literature
- 2019
-
Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier. - 0901-5027 .- 1399-0020. ; 48:7, s. 886-894
-
Forskningsöversikt (refereegranskat)abstract
- The purpose of the present systematic review was to compare the clinic-radiological features of solitary with multiple idiopathic bone cavity (IBC) reported in the jaws. We also aimed to identify possible features that may have some influence on the frequency of persistence of IBC following treatment. An electronic search was undertaken in August/2018. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. A total of 284 publications reporting 1253 IBCs were included. Multiple IBCs affect older patients and more frequently women in comparison to solitary IBCs. While trauma is more commonly found in solitary IBC, scalloping around teeth, bone expansion and persistence of the cavity following treatment were more significantly associated with multiple lesions. The most relevant factors that are suggested to influence the persistence of the cavity are ‘surgical access only’ in comparison to ‘curettage’, presence of scalloping around teeth, patients with multiple IBCs, and increase in size of the lesion. Solitary and multiple IBC differ in some clinical and radiological aspects and show distinct rates of persistence following treatment. Curettage is the treatment of choice for IBC compared to surgical access only.
|
|
| 8. |
- Chrcanovic, Bruno, et al.
(författare)
-
Immediately loaded non-submerged versus delayed loaded submerged dental implants: A meta-analysis.
- 2015
-
Ingår i: International Journal of Oral & Maxillofacial Surgery. - : Elsevier BV. - 0901-5027 .- 1399-0020. ; 44:4, s. 493-506
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present meta-analysis was to test the null hypothesis of no difference in the implant failure rate, postoperative infection, and marginal bone loss for patients being rehabilitated with immediately loaded non-submerged dental implants or delayed loaded submerged implants, against the alternative hypothesis of a difference. An electronic search without time or language restrictions was undertaken in March 2014. Eligibility criteria included clinical human studies, either randomized or not. The search strategy resulted in 28 publications. The inverse variance method was used for a random- or fixed-effects model, depending on the heterogeneity. The estimates of an intervention were expressed as the risk ratio (RR) and mean difference (MD) in millimetres. Twenty-three studies were judged to be at high risk of bias, one at moderate risk of bias, and four studies were considered at low risk of bias. The difference between procedures (submerged vs. non-submerged implants) significantly affected the implant failure rate (P=0.02), with a RR of 1.78 (95% confidence interval (CI) 1.12-2.83). There was no apparent significant effect of non-submerged dental implants on the occurrence of postoperative infection (P=0.29; RR 2.13, CI 0.52-8.65) or on marginal bone loss (P=0.77; MD -0.03, 95% CI -0.23 to 0.17).
|
|
| 9. |
- Chrcanovic, Bruno Ramos, et al.
(författare)
-
Dental implants in patients with Sjögren's syndrome: a case series and a systematic review
- 2019
-
Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027 .- 1399-0020. ; 48:9, s. 1250-1259
-
Forskningsöversikt (refereegranskat)abstract
- The purpose of this study was to assess the clinical outcomes of dental implants in patients with Sjögren's syndrome (SS). The study consisted of two parts: report of a case series and a systematic review of the literature. The results of the clinical series revealed that 19 patients received 107 implants and were followed for a mean of 125 months. Two patients lost three implants (failure rate 2.8%, 3/107). At the last follow-up, there was a mean marginal bone loss (MBL) of −2.190 ± 1.384 mm; estimated MBL after 30 years was 4.39 mm. The review identified 18 studies, resulting in 19 studies for analysis including the present clinical series. A total of 712 implants were placed in 186 patients; 705 implants were followed up for a mean of 72.5 months (failure rate 4.1%, 29/705; failed at a mean time of 12.9 ± 31.7 months). The probability of failure was 2.8% (95% confidence interval 1.6–4.1%). Primary SS patients had a lower implant failure rate (2.5%, 3/118) than secondary SS patients (6.5%, 12/184). In conclusion, dental implants should be considered by dentists as a viable treatment option for patients with SS, as the failure rate is fairly low. SS patients may, however, present a higher MBL around implants than patients from the general population. © 2019 International Association of Oral and Maxillofacial Surgeons
|
|
| 10. |
- Chrcanovic, Bruno
(författare)
-
Surgical versus non-surgical treatment of mandibular condylar fractures : a meta-analysis
- 2015
-
Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier. - 0901-5027 .- 1399-0020. ; 44:2, s. 158-179
-
Forskningsöversikt (refereegranskat)abstract
- The aim of the present study was to test whether there is a significant difference in the clinical outcomes between surgical and non-surgical treatment of mandibular condylar fractures. An electronic search was undertaken in February 2014. Eligibility criteria included clinical human studies, either randomized or not. The search strategy resulted in 36 publications. The estimates of an intervention were expressed as the risk ratio (RR) and mean difference (MD) in millimetres. A statistically significant effect was observed for the outcome of post-treatment malocclusion (RR 0.46, P<0.00001), lateral deviation during maximum inter-incisal opening (RR 0.56, P=0.0001, dichotomous; MD -0.75, P=0.002, continuous), protrusion (MD 0.68, P=0.01), and laterotrusion (MD 0.53, P=0.03) favouring surgical treatment, and for infection (RR 3.43, P=0.03) favouring non-surgical treatment. There was no statistically significant effect on temporomandibular joint pain (RR 0.81, P=0.46) or noise (RR 1.44, P=0.24), or maximum inter-incisal opening (MD 2.24, P=0.14). The test for overall effect showed that the difference between the procedures significantly affected the incidence of post-treatment complications, favouring surgical treatment, when all dichotomous and continuous outcomes were analysed (RR 0.70, P=0.006 and MD 1.17, P=0.0006, respectively).
|
|
