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Träfflista för sökning "L773:0934 0874 OR L773:1432 2277 srt2:(1988-1989)"

Sökning: L773:0934 0874 OR L773:1432 2277 > (1988-1989)

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1.
  • Wallander, J, et al. (författare)
  • Small-bowel transplantation in the rat with a nonsuture cuff technique. Technical and immunological considerations.
  • 1988
  • Ingår i: Transplant International. - 0934-0874 .- 1432-2277. ; 1:3, s. 135-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Small-bowel transplantation (SBT) using an nonsuture cuff technique was carried out on 137 rats. Preparation of the donor graft was carried out according to conventional procedures. Graft perfusion was done at a fixed pressure of 35 cm water. The left renal vessels of the recipient were dissected, the native kidney removed, and the graft was connected to the vessels by a nonsuture cuff technique. Of the animals, 92% survived for at least 5 days posttransplant. Three different combinations were investigated: (1) isografts; (2) semisyngeneic grafts from nontreated Lewis----(Lewis x DA) F1 hybrids; and (3) semisyngeneic grafts from rabbit antilymphocyte globulin (ALG)-pretreated Lewis----(Lewis x DA) F1. In group 1, 80% of the grafts were unaffected after 1 month; flow studies showed slight or no impairment of circulation in the graft. In group 2, the recipients developed clinical signs of graft-versus-host disease (GVHD) after 1 week, and at the end of the 2nd week the animals showed signs of severe illness, leading to death due to GVHD. There was also a higher percentage of complications in this group. In group 3, 65% of the animals died. However, 27% showed intact grafts and no signs of GVDH after 1 month, indicating that antibody pretreatment of the donor may successfully prevent GVHD SBT.
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2.
  • Wanders, A., et al. (författare)
  • The enhancing effect of cyclosporine A and sulfasalazine on the prevention of rejection in rat cardiac allografts
  • 1988
  • Ingår i: Transpl Int. ; 1:2, s. 113-5
  • Tidskriftsartikel (refereegranskat)abstract
    • Sulfasalazine (SASP) has been used for many years as a disease-modifying agent in inflammatory bowel disease and in rheumatoid arthritis. However, its mode of action is not entirely clear. Evidence has been accumulated which indicates that its efficacy is due to an immunomodulatory effect. In the present communication, we report that SASP has an immunomodulatory capacity in an experimental rat cardiac allograft model. A combination of 100 mg/kg per day of SASP given orally until rejection and 10 mg/kg per day of cyclosporine A (CyA) given orally for 10 days resulted in a significantly increased graft survival time as compared to that in animals given CyA alone.
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  • Resultat 1-2 av 2
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tidskriftsartikel (2)
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refereegranskat (2)
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Tufveson, G (2)
Gerdin, B (1)
Larsson, E (1)
Gerdin, Bengt, 1947- (1)
Wanders, A (1)
Wallander, J (1)
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Holtz, A. (1)
Läckgren, G (1)
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Uppsala universitet (2)
Umeå universitet (1)
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Engelska (2)
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Medicin och hälsovetenskap (2)
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1988 (2)

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