| 1. |
- Herlitz, Johan, et al.
(författare)
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Mortality and morbidity during a five-year follow-up of diabetics with myocardial infarction
- 1988
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Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell Publishing Ltd.. - 0954-6820 .- 1365-2796. ; 224:1, s. 31-38
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Tidskriftsartikel (refereegranskat)abstract
- In 787 patients with acute myocardial infarction originally participating in the Göteborg Metoprolol Trial, mortality and morbidity during 5 years' follow-up were assessed and related to whether patients had diabetes mellitus. Diabetes occurred in 78 patients (10%). Patients with diabetes had a different risk factor pattern, including higher age, higher occurrence of angina pectoris and hypertension, whereas smoking habits did not differ. In the early phase (hospitalization), patients with diabetes had a higher mortality (12% versus 8%), required more treatment for heart failure and stayed longer in hospital. Other morbidity aspects, such as severity of pain, occurrence of severe supraventricular and ventricular arrhythmias, high-degree AV-block and infarct size did not differ. During 5 years' follow-up mortality rate in patients with diabetes mellitus was 55% as compared with 30% among patients with no diabetes (P<0.001). Reinfarction rate during 5 years was 42% in daibetics versus 25% in non-diabetics (P<0.001). In a multivariate analysis, taking into account the differences in risk factor pattern, diabetes turned out to be an independent determinant for long-term mortality and reinfarction (P<0.001). We conclude that patients with diabetes mellitus, developing acute myocardial infarction, is a group with particularly high risk of death and reinfarction. Interventions aiming at its reduction have priority.
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| 2. |
- Almroth, Gabriel, et al.
(författare)
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Serum immunoglobulins and IgG subclasses in patients with glomerulonephritis
- 1989
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 225:1, s. 3-7
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Tidskriftsartikel (refereegranskat)abstract
- The serum concentrations of IgG, IgA, IgM and of the four subclasses of IgG were determined by radial immunodiffusion in 103 patients, mean age 42 (range 16–72), with various types of glomerulonephritis. Forty-nine healthy blood donors, mean age 41 years (range 19–65), served as controls. Kidney biopsies were obtained from all the patients for examination by histopathology and by immunofluorescence. The glomerulopathies were classified according to WHO criteria.The serum immunoglobulin patterns were different for the various clinical groups of patients. Patients with Wegener's granulomatosis, rapidly progressive glomerulonephritis and SLE had a significant increase in total IgG and of IgG4 (P < 0.05–0.001). Patients with minimal change disease had low concentrations of IgG (P < 0.001) with a significant decrease in IgG1 and IgG2 (P < 0.001 and 0.01. respectively). Highly significant increases in IgA were noted for patients with IgA nephritis (P < 0.001) but high levels were also seen in patients with chronic glomerulonephritis. The findings might have diagnostic implications.
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| 3. |
- Knutsson, Anders
(författare)
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Relationships between serum trigycerides and g-Glutamyltransferase among shift and day workers
- 1989
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Ingår i: Journal of internal medicine. - 0954-6820. ; 226:5, s. 337-339
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Tidskriftsartikel (refereegranskat)abstract
- Increased levels of serum triglycerides in shift workers have been reported in two population-based studies. In order to examine this relationship and to take some common confounding factors into account this cross-sectional study of 562 shift and day workers was carried out. The shift workers had significantly higher levels of serum triglycerides. gamma-glutamyltransferase and total cholesterol, and Body Mass Index did not differ between the groups. The cause of increased serum concentrations of triglycerides is unclear. The present study provides no evidence to support the assumption that alcohol drinking or obesity accounts for increased levels of serum triglycerides in shift workers.
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