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- Olsson, H., et al.
(författare)
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Relation between age of mothers with breast cancer and sex of their children
- 1980
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Ingår i: British Medical Journal. - : BMJ. - 0959-8146. ; 281:6247, s. 1029-1031
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Tidskriftsartikel (refereegranskat)abstract
- In a consecutive series of 150 women with breast cancer 122 had borne one or more children. Sixty-two patients were aged below 55 years at diagnosis (group A) and 60 were 55 years or older (group B). In group A 91 out of 153 children (59%) were boys compared with 48 out of 141 (34%) in group B (p=0 000007). In group A 54 of the 62 patients (87%) had given birth to one or more boys compared with 35 of the 60 (58%) in group B (p=0 0003). The mean age at diagnosis in mothers of two or more boys was 49 0 years, in those of one boy 55-2 years, and in those of only girls 61 0 years. The differences between each of the mean ages was significant. The mean age at diagnosis in 28 nulliparous patients was 57-7 years. There was no significant correlation between the number of female pregnancies and age at diagnosis. These results suggest that in women liable to develop breast cancer male pregnancies are associated with an early onset of the disease. © 1980, British Medical Journal Publishing Group. All rights reserved.
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| 2. |
- Holm, G, et al.
(författare)
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Severe hypoglycaemia during physical exercise and treatment with beta-blockers
- 1981
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Ingår i: BMJ (Clinical Research Edition). - : BMJ Group. - 0959-8138. ; 282:6273, s. 1360-
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Tidskriftsartikel (refereegranskat)abstract
- Despite important metabolic effects beta-blocking agents are usually well tolerated, but during metabolic stress important perturbations may occur. For instance, treatment with a non-selective beta-blocker leads to a slower rate of recovery from insulin-induced hypoglycaemia. 1 Similarly, blood glucose concentrations are more rapidly reduced during prolonged physical exercise during treatment with a beta-blocker.2 Serious hypoglycaemia has occurred during prolonged exercise in patients receiving treatment with propranolol3 and pindolol.4 We report on a patient treated with alprenolol, a non-selective beta-blocker with intrinsic sympathomimetic activity, who developed serious hypoglycaemia during endurance exercise.
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