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Träfflista för sökning "L773:1045 2257 OR L773:1098 2264 srt2:(1995-1999)"

Sökning: L773:1045 2257 OR L773:1098 2264 > (1995-1999)

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  • Andreasson, Patrik, et al. (författare)
  • BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
  • 1997
  • Ingår i: Genes, Chromosomes and Cancer. - 1045-2257. ; 20:3, s. 299-304
  • Tidskriftsartikel (refereegranskat)abstract
    • A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.
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  • Broberg, K, et al. (författare)
  • Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis
  • 1999
  • Ingår i: Genes, Chromosomes and Cancer. - 1045-2257. ; 24:3, s. 82-278
  • Tidskriftsartikel (refereegranskat)abstract
    • The occurrence of clonal chromosome aberrations in short-term cultures from synovia, osteophytes, and cartilage from patients with osteoarthritis (OA) was recently reported. Among these aberrations, a recurrent involvement of chromosome bands 12q13-15 in structural rearrangements was detected in both synovia and osteophytes. Chromosomal abnormalities of 12q13-15 are frequent among malignant and benign mesenchymal tumors, and it was recently demonstrated that the molecular target in these neoplasms is the HMGIC gene. In this study, we show by fluorescence in situ hybridization that HMGIC was disrupted by rearrangements of 12q15 in synovia from two patients with OA. The finding of HMGIC rearrangement in a lesion that is not traditionally regarded as neoplastic not only widens the spectrum of disorders that may be associated with altered function of this gene, but also provides further support for the notion that genetically rearranged cell populations are part of the OA process.
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  • Resultat 1-10 av 38

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