| 1. |
- Breitholtz, Magnus, et al.
(författare)
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Testing and risk assessment of persistent and bioaccumulating chemical substances - Improvements within REACH?
- 2006
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Ingår i: Human and Ecological Risk Assessment. - : Informa UK Limited. - 1080-7039 .- 1549-7860. ; 12:4, s. 782-805
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Tidskriftsartikel (refereegranskat)abstract
- In the proposed new European chemicals regulations - the REACH system - the improved control of persistent and bioaccumulating substances is stated as one of the tasks being of particular importance. In this article, the reliability and validity of the scientific basis for identification of persistent ( P), bioaccumulating ( B), and toxic ( T) substances, and for assessing the risks that these substances may pose, are discussed. We have used the European Union risk assessment of pentabromodiphenyl ether, PentaBDE ( CAS 32534-81-9) as a study case in the analysis. It is concluded that for PBT substances there is room for development both with regard to test methodology and with regard to risk assessment procedures.
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| 2. |
- Levin, Rikard
(författare)
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Adequacy conditions for reporting uncertainty in chemical risk assessments
- 2006
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Ingår i: Human and Ecological Risk Assessment. - : Informa UK Limited. - 1080-7039 .- 1549-7860. ; 12:5, s. 834-855
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Tidskriftsartikel (refereegranskat)abstract
- Uncertainty may influence decision-making. A prerequisite for a decision to be well founded is thus that scientific experts inform decision-makers about all decision relevant uncertainty. A set of conditions is provided for adequate characterization of scientific uncertainty for the purposes of regulatory decision-making. These conditions require specification of (1) the character and degree of uncertainty about the assessment variables, (2) the possibility of reducing the uncertainty, and (3) the degree of agreement among experts. Furthermore, it is required that (4) the information covered by the previous conditions is presented in a clear and comprehensible way. The point of departure is that characterizing scientific uncertainty conceptually means specifying all potentially important possibilities that are consistent with the state of scientific knowledge. The conditions are intended to be applied to human health risk assessment of chemicals. However, the basic approach, to consider potentially important possibilities, should be useful also to environmental, and site-specific risk assessment.
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