| 1. |
- Ancoli-Israel, Sonia, et al.
(författare)
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The effect of nocturia on sleep
- 2011
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Ingår i: Sleep Medicine Reviews. - : Elsevier BV. - 1087-0792. ; 15:2, s. 91-97
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Forskningsöversikt (refereegranskat)abstract
- Sleep plays a vital role in physical and mental functioning. It is increasingly recognized that disturbed sleep is a highly prevalent and chronic condition that merits greater awareness due to the wide-ranging and serious repercussions associated with it. Nocturia is one of the causes of sleep disturbance and has been shown to impair functioning, quality of life, health and productivity, with those experiencing two or more voids per night reporting significant 'bother'. Nocturia warrants full consideration as a significant target for intervention, aiming to reduce the burden of disturbed sleep on individuals, families and society. Currently, however, a definitive evaluation of the most relevant sleep endpoints in nocturia therapy is lacking. One endpoint often used is the duration of the initial sleep period, which when evaluated in combination with the number of voiding episodes per night, might be an indication of the severity of sleep disruption in patients with nocturia. (C) 2010 Elsevier Ltd. All rights reserved.
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| 2. |
- Ficca, G, et al.
(författare)
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Naps, cognition and performance
- 2010
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Ingår i: Sleep medicine reviews. - : Elsevier BV. - 1532-2955 .- 1087-0792. ; 14:4, s. 249-258
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Manconi, Mauro, et al.
(författare)
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When gender matters : Restless legs syndrome : Report of the "RLS and woman" workshop endorsed by the European RLS Study Group
- 2012
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Ingår i: Sleep Medicine Reviews. - : Elsevier BV. - 1087-0792 .- 1532-2955. ; 16:4, s. 297-307
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Forskningsöversikt (refereegranskat)abstract
- Sleep is an essential human behavior that shows prominent gender differences. Disturbed sleep, in particular, is much more prevalent in females than males. Restless legs syndrome (RLS) as one cause of disturbed sleep was observed to be somewhat more common among women than men in Ekbom's 1945 seminal series of clinical cases with the disease. He, however, reported this gender difference mainly for those with more severe symptoms. Since then numerous studies have reported that women are affected by RLS about twice as often as males for mild as well as moderate to severe RLS. The present review focuses on RLS in females from the perspectives of both epidemiology and pathophysiology. RLS will generally become worse or might appear for the first time during pregnancy. Parity increases the risk of RLS later in life suggesting that pregnancy is a specific behavioral risk factor for developing RLS. Some evidence suggests that dysfunction in iron metabolism and high estrogen levels might contribute to RLS during pregnancy. But, menopause does not lower the incidence of RLS nor does hormone replacement therapy lead to an increase, suggesting a quite complex uncertain role of hormones in the pathophysiology of RLS. Therefore, further, preferably longitudinal studies are needed to unravel the factors causing RLS in women. These studies should include genetic, clinical and polysomnographic variables, as well as hormonal measures and variables assessing iron metabolism.
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