| 1. |
- Norberg-Spaak, Lena, et al.
(författare)
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Adenoid cystic carcinoma : Use of cell proliferation, bcl-2 expression, histologic grade, and clinical stage as predictors of clinical outcome
- 2000
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Ingår i: Head and Neck. - 1043-3074 .- 1097-0347. ; 22:5, s. 489-497
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Tidskriftsartikel (refereegranskat)abstract
- Background. Although the three basic histologic growth patterns of adenoid cystic carcinomas (tubular, cribriform, and solid) provide some indication of clinical outcome, additional, perhaps superior, predictors of biologic activity are needed for patient management. Methods. This series is composed of 31 adenoid cystic carcinomas that presented in Linkoping between 1982 and 1997. The tumors were clinically staged and histologically graded. For each case, after immunohistochemical identification, the proportion of tumor cells expressing the cell cycle markers MIB-1 and bcl-2 (as an indicator of proliferation and apoptosis, respectively) were quantified. Statistical correlation was sought between tumor stage and grade and the two cell cycle markers. Results. The proportions of cycling tumor cells in adenoid cystic carcinomas ranged from 0.3% to 55%. For patients with no evidence of disease and a follow-up of at least 5 years, the mean percent MIB-1 value was significantly lower than for those patients who were alive with local recurrence and/or metastasis or who had died from their adenoid cystic carcinoma (p = .024). MIB-1 tumor cell positivity also correlated strongly with tumor grade (p = .053), but not with stage (p = .22). Neither clinical stage nor histologic grade correlated with the degree of bcl-2 tumor cell positivity (p = .97 and p = .49, respectively). Conclusions. Staging and grading continue to play a vital role in the management of patients with adenoid cystic carcinoma. Furthermore, in this series of patients with adenoid cystic carcinoma, a cycling tumor cell population as measured by the MIB-1 antibody greater than 10% indicates this group as biologically more aggressive and at an increased risk for a fatal course. (C) 2000 John Wiley and Sons, Inc.
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| 2. |
- Bodin, Ingrid, et al.
(författare)
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Intraoral sensation before and after radiotherapy and surgery for oral and pharyngeal cancer.
- 2004
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Ingår i: Head and Neck. - : Wiley. - 1043-3074 .- 1097-0347. ; 26:11, s. 923-929
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Patients with unilateral oral or pharyngeal cancer often receive bilateral radiotherapy because of the potential for metastases. Because postoperative sequelae are evident on the tumor side, to date little attention has been paid to sensory alterations after radiotherapy on the healthy, nontumor side. The objective of this study was to investigate possible sensory alterations. METHODS: Intraoral sensation was tested bilaterally at standardized sites in 27 patients and 20 controls. Preoperative radiotherapy was bilateral in 19 patients and unilateral in eight patients. Patients were tested before treatment, after radiotherapy, and after surgery at 6 months and 1 year. Comparisons were performed interindividually and intraindividually and between groups. RESULTS: A delayed deterioration of sensation was revealed on the nontumor side 6 months after radiotherapy. There was no recovery 1 year after treatment. CONCLUSIONS: Intraoral sensation cannot be evaluated directly after radiotherapy. It is plausible that sensory deterioration after radiotherapy has an impact on functional rehabilitation after tumor treatment.
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