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Träfflista för sökning "L773:1097 2765 srt2:(1998-1999)"

Sökning: L773:1097 2765 > (1998-1999)

  • Resultat 1-7 av 7
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1.
  • Neely, K E, et al. (författare)
  • Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays
  • 1999
  • Ingår i: Molecular Cell. - 1097-2765 .- 1097-4164. ; 4:4, s. 649-655
  • Tidskriftsartikel (refereegranskat)abstract
    • The yeast SWI/SNF complex is required for the transcription of several yeast genes and has been shown to alter nucleosome structure in an ATP-dependent reaction. In this study, we show that the complex stimulated in vitro transcription from nucleosome templates in an activation domain-dependent manner. Transcription stimulation by SWI/SNF required an activation domain with which it directly interacts. The acidic activation domains of VP16, Gcn4, Swi5, and Hap4 interacted directly with the purified SWI/SNF complex and with the SWI/SNF complex in whole-cell extracts. The similarity of activation domain interactions and transcriptional stimulation between SWI/SNF and the SAGA histone acetyltransferase complex may account for their apparent overlapping functions in vivo.
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2.
  • Hedengren, Marika, et al. (författare)
  • Relish, a central factor in the control of humoral but not cellular immunity in Drosophila.
  • 1999
  • Ingår i: Mol Cell. - : Elsevier. - 1097-2765. ; 4:5, s. 827-37
  • Tidskriftsartikel (refereegranskat)abstract
    • The NF-kappa B-like Relish gene is complex, with four transcripts that are all located within an intron of the Nmdmc gene. Using deletion mutants, we show that Relish is specifically required for the induction of the humoral immune response, including both antibacterial and antifungal peptides. As a result, the Relish mutants are very sensitive to infection. A single cell of E. cloacae is sufficient to kill a mutant fly, and the mutants show increased susceptibility to fungal infection. In contrast, the blood cell population, the hematopoietic organs, and the phagocytic, encapsulation, and melanization responses are normal. Our results illustrate the importance of the humoral response in Drosophila immunity and demonstrate that Relish plays a key role in this response.
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7.
  • Karimi, R, et al. (författare)
  • Novel roles for classical factors at the interface between translation termination and initiation
  • 1999
  • Ingår i: MOLECULAR CELL. - : CELL PRESS. - 1097-2765. ; 3:5, s. 601-609
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The pathway of bacterial ribosome recycling following translation termination has remained obscure, Here, we elucidate two essential steps and describe the roles played by the three translation factors EF-G, RRF, and IF3. Release factor RF3 is known to ca
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  • Resultat 1-7 av 7

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