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- Abrahamson, Magnus, et al.
(författare)
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The human cystatin C gene (CST3), mutated in hereditary cystatin C amyloid angiopathy, is located on chromosome 20
- 1989
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Ingår i: Human Genetics. - 1432-1203. ; 82:3, s. 223-226
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Tidskriftsartikel (refereegranskat)abstract
- Hereditary cystatin C amyloid angiopathy has recently been shown to be caused by a point mutation in the cystatin C gene. To determine the chromosomal localization of the gene, 20 human-rodent somatic cell hybrids and a fulllength cystatin C cDNA probe were used. Southern blot analysis of BamHI digested cell hybrid DNA revealed that the probe recognizes a 10.6 kb human specific fragment and that this fragment cosegregates with human chromosome 20. Therefore, the human cystatin C gene (CST3) was assigned to chromosome 20.
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| 3. |
- Alafuzoff, I, et al.
(författare)
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Histopathological criteria for progressive dementia disorders : clinical-pathological correlation and classification by multivariate data analysis.
- 1987
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Ingår i: Acta Neuropathologica. - 0001-6322 .- 1432-0533. ; 74:3, s. 209-25
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Tidskriftsartikel (refereegranskat)abstract
- Autopsied brains from 55 patients with dementia between 59-95 years of age (mean age 77.9 +/- 8.1 years) and 19 non-demented individuals between 46-91 years of age (mean age 74.3 +/- 10.5 years) were examined to establish histopathological criteria for normal ageing, primary degenerative [Alzheimer's disease (AD)/senile dementia of Alzheimer type (SDAT)] and vascular (multi-infarct) dementia (MID) disorders. Senile/neuritic plaques, neurofibrillary tangles, microscopic infarcts and perivascular serum protein deposits were quantified in the frontal lobe (Brodmann area 10) and in the hippocampus. The demented patients were classified according to the DSM-III criteria into AD/SDAT and MID. Operationally defined histopathological criteria for dementias, based on the degree/amount of the histopathological changes seen in aged non-demented patients, were postulated. The demented patients were clearly separable into three histopathological types, namely AD/SDAT, MID and AD-MID, the dementia type where both the degenerative and the vascular changes are coexistent in greater extent than are seen in the non-demented individuals. Using general clinical, gross neuroanatomical and histopathological data three separate dementia classes, namely AD/SDAT, MID and AD-MID, were visualized in two-dimensional space by multivariate data analysis. This analysis revealed that the pathology in the AD-MID patients was not merely a linear combination of the pathology in AD/SDAT and MID, indicating that AD-MID might represent a dementia type of its own. The clinical diagnosis for AD/SDAT and MID was certain in only half of the AD/SDAT and one third of the MID cases when evaluated histopathologically and by multivariate data analysis. AD/SDAT, MID and AD-MID were histopathologically diagnosed in 49%, 24% and 27%, respectively, of all the dementia cases studied. Opposite correlation between the number of tangles, plaques and the patient age in non-demented and AD/SDAT cases were observed, indicating that the pathogenesis of tangles and plaques in the two groups of patients might be different and that AD/SDAT might not be a form of an exaggerated ageing process.
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| 9. |
- Andrén, O., et al.
(författare)
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Barley straw decomposition with varied levels of microbial grazing by Folsomia fimetaria (L.) (Collembola, Isotomidae)
- 1985
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Ingår i: Oecologia. - : Springer-Verlag New York. - 0029-8549 .- 1432-1939. ; 68:1, s. 57-62
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Tidskriftsartikel (refereegranskat)abstract
- Folsomia fimetaria (L.) were added (0, 5, 10, 20 animals) to 0.100 g barley straw which had been inoculated 10 days (244 h) earlier with a natural soil microflora. Respiration (CO2 evolution) was monitored continuously. Mass loss, fungal standing crop (total and FDA-active), bacterial and protozoan biomass were estimated 42 days (1,000 h) after microbial inoculation. The degree of surface cover by hyphae was surveyed at regular intervals. No significant differences (P>0.05) were found in respiration, mass loss or microbial biomass, but the density of surface hyphae were reduced by addition of Collembola. Fungal production was low, less than 5% of the estimated microbial production, and could not account for all collembolan growth during incubation. F. fimetaria appeared to consume mainly bacteria and protozoa, and had little impact on carbon mineralization.
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| 10. |
- Angerbjörn, Anders
(författare)
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Mountain Hare Populations on Islands - Effects of Predation by Red Fox
- 1989
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Ingår i: Oecologia. - New York : Springer Verlag. - 0029-8549 .- 1432-1939. ; 81:3, s. 335-340
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Tidskriftsartikel (refereegranskat)abstract
- On islands off the west coast of Sweden the density of mountain hares (Lepus timidus L.) is very high. One of the main predators on hares, the red fox (Vulpes vulpes L.), is only present during short periods. Data on hare density and predation by red fox and eagle owl (Bubo bubo (L.)) has been analyzed from five islands over several years. Winter mortality in years with low predation pressure was independent of hare density. But when red fox or eagle owl were present on islands (i.e., high predation pressure) winter mortality became density dependent. Thus, at low density, winter mortality did not increase through red fox predation. But at densities up to two hares/ha, predation pressure was increasing and could be limiting for these populations. At still higher hare density predation pressure became less intensive. The functional response for foxes preying on hares showed a type II or a sigmoid type III response pattern. In normal summers, the population increase due to reproduction was at least two-fold. When a fox was present there was instead a sharp decrease in hare numbers. Fox predation had a stronger effect in summer than in winter. By switching between islands and mainland areas from winter to summer, a fox can stabilize fluctuations in hare numbers on the islands. This is dependent on how often the ice permits a fox to reach an island and the lack of numerical response by predators.
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