| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Jansson, Lennart, et al.
(författare)
-
Needs assessed by psychiatric health care and social services in a defined cohort of clients with mental disabilities
- 2005
-
Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 255:1, s. 57-64
-
Tidskriftsartikel (refereegranskat)abstract
- Background The identification of needs forsupport and service in clients with long-term mentaldisabilities is usually not done by staff personnel fromboth psychiatric care and social services.However, sucha process is probably necessary in order to provide adequatepsychiatric care and social services. Aims To estimatethe prevalence of mentally disabled clients and investigatewhether staff from psychiatric care and socialservices identified the same individuals and the samenumber of needs in the same areas. Methods Clientsfrom a defined catchment area were identified during athree-month period. A questionnaire was developed tocollect socio-demographic information and to assessneeds for support and service. Results The study identified1,290 clients with needs with a prevalence of5.72/1000 inhabitants. More than half of the clientsneeded support in activities of daily living. Only 18.1%of the clients were identified by both organizations. Ingeneral, the staff from psychiatric care and social servicesidentified the same needs at a group level. However,at the individual level, agreement was quite low.Conclusions The staffs from both psychiatric care andsocial services are necessary to evaluate the needs ofsupport and services in clients with mental disabilities.
|
|
| 5. |
|
|
| 6. |
- Kuhn, Hans-Georg, 1961, et al.
(författare)
-
Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?
- 2007
-
Ingår i: European archives of psychiatry and clinical neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 257:5, s. 281-9
-
Forskningsöversikt (refereegranskat)abstract
- Alzheimer's disease and related dementias are devastating disorders that lead to the progressive decline of cognitive functions. Characteristic features are severe brain atrophy, paralleled by accumulation of beta amyloid and neurofibrillary tangles. With the discovery of neurogenesis in the adult brain, the hopes have risen that these neurodegenerative conditions could be overcome, or at least ameliorated, by the generation of new neurons. The location of the adult neurogenic zones in the hippocampus and the lateral ventricle wall, close to corpus callosum and neocortex, indicates strategic positions for potential repair processes. However, we also need to consider that the generation of new neurons is possibly involved in cognitive functions and could, therefore, be influenced by disease pathology. Moreover, aberrant neurogenic mechanisms could even be a part of the pathological events of neurodegenerative diseases. It is the scope of this review to summarize and analyze the recent data from neurogenesis research with respect to Alzheimer's disease and its animal models.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Pagani, M, et al.
(författare)
-
Regional cerebral blood flow during auditory recall in 47 subjects exposed to assaultive and non-assaultive trauma and developing or not posttraumatic stress disorder
- 2005
-
Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 255:5, s. 359-365
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Psychological trauma leads to posttraumatic stress disorder (PTSD) in susceptible subjects. The aim of this study was to investigate the differences in regional cerebral blood flow (rCBF) between two groups of subjects exposed to different types of traumatic stressor either developing or not developing PTSD. METHODS: Twenty subjects developing (S) and 27 not developing (NS) PTSD after being exposed to either earlier person-under-the-train accident (NA) or being assaulted in the underground environment (A) were included in the study. 99mTc-HMPAO SPECT was performed and the uptake in 29 regions of the brain (VOIs), bilaterally, was assessed. rCBF distribution was compared, using analysis of variance (ANOVA), between groups (S/NS) and type (A/NA) during a situation involving an auditory evoked re-experiencing of the traumatic event. Discriminant analysis was applied to test the concordance between clinical diagnosis and SPECT findings. RESULTS: In the general analyses significant differences were found between groups and types and there was a significant hemisphere x type interaction. S showed higher CBF than NS and so did A as compared to NA, particularly in the right hemisphere. Discriminant analysis correctly classified 66% of cases (p < 0001) in testing S/NS and 72% (p < 0001) in testing NA/A. CONCLUSIONS: Under recall of their traumatic experience we found higher relative CBF distribution values in S as compared to NS. CBF was higher in the right hemisphere and particularly in assaulted subjects. These findings underscore the role upon trauma recall of both the right hemisphere and the nature of the stressing event.
|
|
| 10. |
|
|
