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- Cao, Yihai
(författare)
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Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
- 2013
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Ingår i: Trends in Molecular Medicine. - : Elsevier. - 1471-4914 .- 1471-499X. ; 19:8, s. 460-473
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Forskningsöversikt (refereegranskat)abstract
- Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are frequently expressed in various tumors and their expression levels correlate with tumor growth, invasiveness, drug resistance, and poor clinical outcomes. Emerging experimental evidence demonstrates that PDGFs exhibit multiple functions in modulation of tumor growth, metastasis, and the tumor microenvironment by targeting malignant cells, vascular cells, and stromal cells. Understanding PDGF PDGFR-mediated molecular signaling may provide new mechanistic rationales for optimizing current cancer therapies and the development of future novel therapeutic modalities.
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| 2. |
- Rollano Penaloza, Oscar M., et al.
(författare)
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Apoptins : selective anticancer agents
- 2014
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Ingår i: Trends in Molecular Medicine. - : Elsevier BV. - 1471-4914 .- 1471-499X. ; 20:9, s. 519-528
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Forskningsöversikt (refereegranskat)abstract
- Therapies that selectively target cancer cells for deathhave been the center of intense research recently. Onepotential therapy may involve apoptin proteins, whichare able to induce apoptosis in cancer cells leavingnormal cells unharmed. Apoptin was originally discoveredin the Chicken anemia virus (CAV); however, humangyroviruses (HGyV) have recently been found that alsoharbor apoptin-like proteins. Although the cancer cellspecific activity of these apoptins appears to be wellconserved, the precise functions and mechanisms ofaction are yet to be fully elucidated. Strategies for bothdelivering apoptin to treat tumors and disseminating theprotein inside the tumor body are now being developed,and have shown promise in preclinical animal studies.
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| 5. |
- Westermark, Gunilla T., et al.
(författare)
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Prion-like aggregates : infectious agents in human disease
- 2010
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Ingår i: Trends in Molecular Medicine. - : Elsevier BV. - 1471-4914 .- 1471-499X. ; 16:11, s. 501-507
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Forskningsöversikt (refereegranskat)abstract
- According to the 'protein only hypothesis', Creutzfeldt- Jakob disease and other prion disorders are transmissible by misfolded and aggregaled prion proteins that act as templates for the misfolding of the same protein in the recipient. The misfolding and aggregation of the prion protein are akin to the genesis of amyloid fibrils formed by several human and animal proteins associated with more common diseases. Two murine forms of amyloidosis, including a model of human AA amyloidosis, are transmissible. Here, we explore the possibility that human prion diseases and more common maladies associated with amyloid deposits might be transmissible by seeding or perhaps even by crossing species barriers.
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| 6. |
- Hansen, Christian, et al.
(författare)
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Beyond α-synuclein transfer: pathology propagation in Parkinson's disease.
- 2012
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Ingår i: Trends in Molecular Medicine. - : Elsevier BV. - 1471-4914. ; 18:5, s. 248-255
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Tidskriftsartikel (refereegranskat)abstract
- α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures. Recent studies have shown that α-syn can be transmitted between neurons and can seed the formation of toxic aggregates in recipient neurons in a prion-like manner. In addition, it is known that Lewy body pathology may spread gradually and systematically from the peripheral or enteric nervous system or olfactory bulb to specific brain regions during progression of idiopathic PD. It is therefore conceivable that α-syn species could act as seeds that drive PD progression. Here, we review recent advances from studies of α-syn cell-to-cell transfer, the current understanding of α-syn toxicity, and how these relate to progression of PD pathology.
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