| 1. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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HLA haplotypes in a family with ankylosing-spondylitis and rheumatoid-arthritis
- 1985
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Ingår i: Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 12:3, s. 518-522
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Tidskriftsartikel (refereegranskat)abstract
- HLA haplotypes (including A, B, C and DR loci) were studied in a family with members who had both rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Sacroiliitis was found in 7 family members, one of whom had AS and 2 others erosive, seropositive RA. They carried the B27-DR4 haplotype, suggesting a possible dual genetic association of the same haplotype in both RA and AS. Three other different HLA-B27 containing haplotype were found, 2 of which could be associated with sacroiliitis/AS. Within this family sacroiliitis and/or AS rather seemed associated with the B27 antigen itself than with the same haplotype.
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| 2. |
- Geborek, Pierre, et al.
(författare)
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Joint capsular stiffness in knee arthritis. Relationship to intraarticular volume, hydrostatic pressures, and extensor muscle function
- 1989
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Ingår i: Journal of Rheumatology. - 0315-162X. ; 16:10, s. 1351-1358
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Tidskriftsartikel (refereegranskat)abstract
- Increased intraarticular hydrostatic pressure (Pia) may inhibit juxtaarticular muscle function, obstruct blood supply to joint structures and promote anoxic joint destruction in chronic arthritis. Joint capsular stiffness together with synovial fluid volume determines Pia at rest. Seventeen knee joints with effusive arthritis and different degrees of radiological cartilage involvement in 13 patients with chronic arthritis were examined. Since capsular elastance was difficult to standardize, we introduce a measure of joint capsular stiffness where the intraarticular volume yielding a pressure of 50 mm Hg (V50) is used. After normalization of injected volumes according to the V50, pressure volume curves became similar. Intraarticular hydrostatic pressure and maximal voluntary isometric extensor torque were measured simultaneously, while altering the intraarticular fluid volume in 9 knee joints. In 5 of these, quantified electromyography (EMG) of the vastus medialis and lateralis portion of the quadriceps muscle was also monitored. Progressive inhibition of extensor torque and EMG was found as the intraarticular pressure volume was increased in both intact and destroyed joints. No difference in inhibition was found for the 2 portions of quadriceps muscle tested. Increased intraarticular hydrostatic pressure Pia levels between 200 and 1150 mm Hg were observed during maximal voluntary activation of extensor muscles. The reproducibility was good for all variables studied. In a few instances evidence of intraarticular compartmentalization was found at low volumes. We conclude that the V50 is a convenient expression of capsular stiffness. Furthermore, increasing Pia caused by joint effusion inhibits knee extensor muscle function and impairs synovial blood flow. Awareness of these relations will facilitate more rational therapeutic approaches in chronic arthritis.
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| 3. |
- Geborek, Pierre, et al.
(författare)
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Measurement of synovial fluid volume using albumin dilution upon intraarticular saline injection
- 1988
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Ingår i: Journal of Rheumatology. - 0315-162X. ; 15:1, s. 91-94
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Tidskriftsartikel (refereegranskat)abstract
- A simple method for measuring synovial fluid (SF) volume is described. The degree of dilution of SF albumin after intraarticular injection of a defined volume of saline was used to calculate residual SF volume. Good correlation between calculated and aspirated SF volume was found for knee joint exudates. The method is simple, requires no radioactive tracer and should be useful in quantitative studies involving SF pathophysiology. Interestingly, the major portion of the SF could be directly aspirated, since residual volumes were small in comparison.
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| 4. |
- Geborek, Pierre, et al.
(författare)
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Synovial fluid acidosis correlates with radiological joint destruction in rheumatoid arthritis knee joints
- 1989
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Ingår i: Journal of Rheumatology. - 0315-162X. ; 16:4, s. 468-472
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Tidskriftsartikel (refereegranskat)abstract
- Metabolic variables in samples of synovial fluid (SF) from 33 rheumatoid arthritis (RA) knees were analyzed. These variables were correlated with radiological destruction and SF proteoglycan concentrations. SF acidosis correlated with radiological involvement (rs = 0.62, p less than 0.002), but not with proteoglycan concentrations. A weak correlation was found between SF acidosis and granulocyte concentrations (rs = 0.37, 0.02 less than p less than 0.05). Metabolic variables covaried as expected. Samples from right and left knees from the same patients correlated regarding cellular and metabolic variables. Our results indicate insufficient nutritional supply in RA joints with increasing radiological involvement.
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| 5. |
- Heinegård, Dick, et al.
(författare)
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Cartilage proteoglycans in degenerative joint disease.
- 1987
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Ingår i: Journal of Rheumatology. - 0315-162X. ; 14 (suppl 14):SPEC.NO., s. 110-112
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Tidskriftsartikel (refereegranskat)abstract
- Cartilage content of proteoglycans decreases early in induced degenerative hip joint disease. Remaining molecules show structural changes indicating fragmentation. Fragments lost from the articular cartilage are released to the synovial fluid, where they can be quantified by enzyme linked immunosorbent assay. Their amounts are related to the activity of the disease process.
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| 6. |
- Saxne, Tore, et al.
(författare)
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Cartilage derived proteoglycans in body fluids of children. Inverse correlation with age.
- 1989
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Ingår i: Journal of Rheumatology. - 0315-162X. ; 16:10, s. 1341-1344
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Tidskriftsartikel (refereegranskat)abstract
- We have previously shown synovial fluid (SF) proteoglycan concentrations to be sensitive markers of altered cartilage metabolism in arthritis. We determined the proteoglycan concentrations in sera and SF from 23 patients with juvenile chronic arthritis and in sera from 30 healthy children by a specific enzyme linked immunosorbent assay. In both groups of children, decreasing concentrations of proteoglycans were seen during growth. Changes were most marked at the age of 12-13. The serum levels were higher in the healthy children. Our results suggest an age related metabolic change of articular cartilage, resulting in diminished release of proteoglycans to SF and blood with growing age up to 20 years. Measurement of proteoglycans could be a useful tool for studying this process.
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