| 1. |
- Nardella, F A, et al.
(författare)
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Fc epitopes for human rheumatoid factors and the relationships of rheumatoid factors to the Fc binding proteins of microorganisms
- 1988
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Ingår i: Scandinavian Journal of Rheumatology. Supplement. - : Informa UK Limited. - 1502-7740 .- 0300-9742 .- 1502-7732. ; 17:Suppl. 75, s. 190-198
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Tidskriftsartikel (refereegranskat)abstract
- Work from our laboratories has shown that the major antigenic determinants for rheumatoid factors (RFs) are in the C gamma 2-C gamma 3 interface region of IgG in the same area that binds staphylococcal protein A (SPA). Furthermore, the Fc binding proteins of groups A, C and G streptococci as well as the Fc binding proteins induced on cell surfaces by herpes simplex virus type I also bind to the same area of IgG. These binding site similarities between RFs and the microbial Fc binding proteins suggested conformational similarities between the RF antigen combining regions and the Fc binding regions of the microbial proteins. This hypothesis was supported by the observation that antibodies to SPA bind to the antigen combining regions of most RFs as well as to the Fc binding region of the T15 group A streptococcal Fc binding protein. These findings indicate that RFs bear the conformational internal image of these microbial proteins and suggest that RFs could arise as antibodies to the idiotypic determinants on antibodies to microbial Fc binding proteins. Alternatively, microbial Fc binding proteins could present IgG to the immune system in a way that renders specific areas of the C gamma 2-C gamma 3 interface region immunogenic. These relationships between RFs and microbial Fc binding proteins may prove to be important for our understanding of the generation of RFs in rheumatoid arthritis.
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| 2. |
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| 3. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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Acetylator phenotypes in rheumatoid-arthritis patients with or without adverse drug-reactions to sodium-aurothiomalate or d-penicillamine
- 1987
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Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 16:4, s. 235-239
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Tidskriftsartikel (refereegranskat)abstract
- The acetylator phenotype was determined in 59 patients with classical, seropositive and erosive rheumatoid arthritis (RA) treated with sodium-aurothiomalate or d-penicillamine. Patients with adverse drug reactions (ADR) leading to drug withdrawal (n=29) were compared with a group of patients without ADR (n=30). The frequency of slow acetylators was significantly (p< 0.05) increased in all RA patients, irrespective of the presence of ADR, particularly in the male patients, compared with a control population. No association was found between acetylator phenotype and clinical data or secondary Sjögrens's syndrome (SS).
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| 4. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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Clinical symptoms and HLA antigens in a family with reiters disease
- 1985
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Ingår i: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 14:2, s. 149-158
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Tidskriftsartikel (refereegranskat)abstract
- A clinical and immunogenetic study was performed on a three-generation family with Reiter's disease (RD). Twelve of 56 members of the family (33 clinically examined) including one in-law, had symptoms of arthritis, urethritis, conjunctivitis, uveitis, and/or mucocutaneous manifestations, but only one had the complete triad of Reiter's syndrome (RS). Radiographic sacro-iliitis was found in 7 individuals, and monoarticular onset was reported in 5 out of 7 with peripheral arthritis. HLA B27 was found in 26 of the 37 family members who were tissue typed (including one in-law). All individuals with RD were B27-positive. Seven different B27 phenotypes were identified. This finding suggests that RD is associated with the B27 antigen itself, and not to a gene closely linked to B27. From a pedigree analysis of this family an autosomal dominant inheritance with incomplete penetrance or multifactorial inheritance seemed the most probable alternatives. The family history is a useful adjunct in the diagnosis of RD.
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| 5. |
- Dahlqvist, Solbritt Rantapää
(författare)
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Genetic-markers in rheumatoid-arthritis
- 1986
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Ingår i: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 15:Suppl. 58, s. 1-29
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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HLA antigens in rheumatoid-arthritis patients with and without a family history of polyarthritis
- 1985
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Ingår i: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 14:4, s. 375-380
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Tidskriftsartikel (refereegranskat)abstract
- The HLA antigens, A, B and DR, were studied in 141 patients with erosive, seropositive rheumatoid arthritis (RA). The frequency of the B27 antigen was significantly increased among patients with a family history of symmetrical polyarthritis compared with blood donor controls (p<0.001) and with patients without a family history of polyarthritis (p<0.005). The frequency of DR4 was significantly (p<0.001) increased among the RA patients, but there was no significant association between DR4 and a family history of polyarthritis.
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| 7. |
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| 8. |
- Löfkvist, U-B, et al.
(författare)
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Individually adapted lightweight walking aids with moulded handles for patients with severely deforming chronic arthritis
- 1988
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Ingår i: Scandinavian Journal of Rheumatology. - 1502-7732. ; 17:3, s. 167-173
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Tidskriftsartikel (refereegranskat)abstract
- Patients with severely deforming rheumatoid arthritis and impaired function of the upper extremity are often unable to use conventional walking aids. This report describes 42 such patients who were equipped with altogether 75 individually manufactured, lightweight walking aids (12 crutches, 12 forearm-crutches, 39 crutch-sticks and 12 sticks). A plaster cast of the patient's grip as well as analysis of the integrated function of the shoulder-elbow-wrist was used when preparing the walking aid. It was thereby possible to produce suitable walking aids for all but one patient. At follow-up after 12-18 months, of use, most patients belonging to functional classes II and III were satisfied with their walking aid(s) and 22 considered it/them indispensable. However, in 4 patients, progressive disease with increased disease activity/deteriorating hand function and in 3 patients increasing shoulder pain reduced their usability. Lack of motivation was one reason for low use intensity. Follow-up demonstrated that most patients were able to use these walking aids without detectable negative effects on the upper extremity. The durability of the walking aid was satisfactory. Thus an individually moulded handle on an adapted lightweight walking aid is important helping patients with severely deforming arthritis to maintain independent ambulation, and should be made more widely obtainable.
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| 9. |
- Mogensen, Brynjolfur, et al.
(författare)
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Surface replacement of the hip in juvenile chronic arthritis
- 1981
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Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 10:4, s. 269-272
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Tidskriftsartikel (refereegranskat)abstract
- Seventeen resurfacing arthroplasties undertaken in 13 patients with severe hip arthritis are described. The youngest patient was 14 years and the mean age 23 years. The average follow-up time is 2 years. In one patient, pain-free for 7 months, the femoral cup slipped and revision into total hip replacement was easily performed. The remaining patients are pain-free, have increased motion, a better walking capacity and can enjoy sex life. The tremendous improvement in quality of life for these young patients justifies operation even if all may have to be converted into total hip replacement within a couple of years, although there is nothing to indicate that in this early follow-up.
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| 10. |
- Redlund-Johnell, Inga, et al.
(författare)
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Backward tilting of the posterior atlantal arch in rheumatoid arthritis
- 1989
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Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 18:5, s. 261-263
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Tidskriftsartikel (refereegranskat)abstract
- In a retrospective survey of 450 patients with rheumatoid arthritis on whom cervical spine radiography was performed, one patient was found with a backward tilting of the posterior arch of the atlas. With preserved relations anteriorly, the posterior arch was rotated downward in front of the spinous process of the axis, encroaching on the space of the spinal canal.
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