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Träfflista för sökning "L773:1529 8027 OR L773:1085 9489 srt2:(2015-2019)"

Sökning: L773:1529 8027 OR L773:1085 9489 > (2015-2019)

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  • de Carvalho, Mamede, et al. (författare)
  • Peripheral neuropathy in ALS : Phenotype association
  • 2018
  • Ingår i: Journal of the peripheral nervous system. - : John Wiley & Sons. - 1085-9489 .- 1529-8027. ; 23:4, s. 391-392
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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  • Kapoor, M., et al. (författare)
  • Plasma neurofilament light chain concentration is increased and correlates with the severity of neuropathy in hereditary transthyretin amyloidosis
  • 2019
  • Ingår i: Journal of the Peripheral Nervous System. - : Wiley. - 1085-9489 .- 1529-8027. ; 24:4, s. 314-319
  • Tidskriftsartikel (refereegranskat)abstract
    • Hereditary transthyretin amyloidosis (ATTRm) causes a disabling peripheral neuropathy as part of a multisystem disorder. The recent development of highly effective gene silencing therapies has highlighted the need for effective biomarkers of disease activity to guide the decision of when to start and stop treatment. In this study, we measured plasma neurofilament light chain (pNfL) concentration in 73 patients with ATTR and found that pNfL was significantly raised in ATTRm patients with peripheral neuropathy compared to healthy controls. Furthermore, pNFL correlated with disease severity as defined by established clinical outcome measures in patients for whom this information was available. These findings suggest a potential role of pNfL in monitoring disease activity and progression in ATTRm patients.
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  • Løseth, Sissel, et al. (författare)
  • Small and large fiber neuropathy in those with type 1 and type 2 diabetes : a 5-year follow-up study
  • 2016
  • Ingår i: Journal of the peripheral nervous system. - : Wiley. - 1085-9489 .- 1529-8027. ; 21:1, s. 15-21
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this study was to evaluate progression of diabetic polyneuropathy and differences in the spectrum and evolution of large- and small-fiber involvement in patients with diabetes type 1 and 2 over 5 years. Fifty-nine patients (35 type 1 and 24 type 2) were included. Nerve conduction studies (NCS), quantitative sensory testing, skin biopsy for quantification of intraepidermal nerve fiber density (IENFD), symptom scoring and clinical evaluations were performed. Z-scores were calculated to adjust for the physiologic effects of age and height/gender. Neuropathic symptoms were not significantly more frequent in type 2 than in type 1 diabetic patients at follow-up (54% vs. 37%). The overall mean NCS Z-score remained within the normal range, but there was a small significant decline after 5 years in both groups: type 1 (p = 0.004) and type 2 (p = 0.02). Mean IENFD Z-scores changed from normal to abnormal in both groups, but only significantly in those with type 2 diabetes (reduction from 7.9 +/- 4.8 to 4.3 +/- 2.8 fibers/mm, p = 0.006). Cold perception threshold became more abnormal only in those with type 2 diabetes (p = 0.049). There was a minimal progression of large fiber neuropathy in both groups. Reduction of small fibers predominated and progressed more rapidly in those with type 2 diabetes.
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