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| 2. |
- Gisselsson Nord, David, et al.
(författare)
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Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics
- 1999
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Ingår i: American Journal of Surgical Pathology. - 1532-0979. ; 23:10, s. 1300-1300
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Tidskriftsartikel (refereegranskat)abstract
- Chondroid lipoma is a rare, benign tumor that may mimic soft-tissue sarcoma clinically. Its histopathologic features may resemble hibernoma, myxoid liposarcoma, myxoid chondrosarcoma, and other lipomatous or chondroid neoplasms. In this study, a chondroid lipoma was analyzed by fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and metaphase fluorescence in situ hybridization. The results demonstrate that chondroid lipoma exhibits a characteristic pattern by fine-needle aspiration cytology, including a mixture of benign adipose tissue with lipoblastlike cells, and chondroblastlike cells with a fibrochondroid matrix. Cytogenetically, a three-way rearrangement between chromosomes 1, 2, and 5 was found, together with an 11;16 translocation with a breakpoint in 11q13, approximately 1 Mb proximal to the MEN1 region shown to be rearranged frequently in hibernoma. The presence of a karyotype of low complexity, but without any of the genetic aberrations characteristic for other types of soft-tissue tumors, indicate that chondroid lipoma develops along a unique pathogenetic pathway.
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| 3. |
- Ladisch, S, et al.
(författare)
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Langerhans cell granulomatosis
- 1997
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Ingår i: The American journal of surgical pathology. - : Ovid Technologies (Wolters Kluwer Health). - 0147-5185. ; 21:12, s. 1523-1523
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Parada, Luis Antonio, et al.
(författare)
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Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma
- 1997
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Ingår i: American Journal of Surgical Pathology. - 1532-0979. ; 21:11, s. 6-1381
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Tidskriftsartikel (refereegranskat)abstract
- Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood tumors, providing further support for the importance of these abnormalities in the development of hepatoblastoma, the level of genomic complexity seen in the present case has never been described in childhood hepatoblastomas and may suggest a different etiology or pathogenesis.
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