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Search: L773:1534 5807 OR L773:1878 1551 > (2003-2004)

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1.
  • Kreuger, Johan, et al. (author)
  • Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity.
  • 2004
  • In: Developmental Cell. - : Elsevier BV. - 1534-5807 .- 1878-1551. ; 7:4, s. 503-512
  • Journal article (peer-reviewed)abstract
    • The glypican family of heparan sulfate proteoglycans has been implicated in formation of morphogen gradients. Here, we examine the role of the glypican Dally-like protein (Dlp) in shaping the Wingless gradient in the Drosophila wing disc. Surprisingly, we find that Dlp has opposite effects at high and low levels of Wingless. Dlp promotes low-level Wingless activity but reduces high-level Wingless activity. We present evidence that the Wg antagonist Notum acts to induce cleavage of the Dlp glypican at the level of its GPI anchor, which leads to shedding of Dlp. Thus, spatially regulated modification of Dlp by Notum employs the ligand binding activity of Dlp to promote or inhibit signaling in a context-dependent manner. Notum-induced shedding of Dlp could convert Dlp from a membrane-tethered coreceptor to a secreted antagonist.
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3.
  • Hultmark, Dan, et al. (author)
  • A cytokine in the Drosophila stress response.
  • 2003
  • In: Dev Cell. - 1534-5807. ; 5:3, s. 360-1
  • Journal article (peer-reviewed)abstract
    • The fruit fly, Drosophila melanogaster, has become a popular tool for studying immediate reactions to environmental hazards, such as the heat shock and innate immune responses. In mammals, protective responses to infections and other insults are coordinated by a complex network of cytokines that mediate cell-to-cell signaling. By contrast, the corresponding heat shock and innate immune responses in Drosophila have usually been regarded as cell-autonomous processes. However, in this issue of Developmental Cell, show that cytokines do play a role in mediating an acute phase response in this organism.
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  • Result 1-3 of 3

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