| 1. |
- Hägg, S, et al.
(författare)
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Leptin concentrations are increased in subjects treated with clozapine or conventional antipsychotics.
- 2001
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Ingår i: Journal of Clinical Psychiatry. - 0160-6689 .- 1555-2101. ; 62:11, s. 843-848
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Overweight is a considerable clinical problem in patients treated with antipsychotic agents. Recent results suggest that insulin resistance with increased insulin levels is also associated with treatment with the atypical antipsychotic agent clozapine. Leptin is important for the control of body weight and has been proposed to be a link between obesity and the insulin resistance syndrome. This study examined if clozapine-treated subjects and subjects treated with conventional antipsychotics had increased leptin levels compared with the general population and whether there was a gender difference in this respect.METHOD: Clozapine-treated patients (N = 41), patients treated with conventional antipsychotic drugs (N = 62), and healthy subjects from the Northern Sweden Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) project (N = 189) were investigated with a cross-sectional study design. Weight, body mass index (BMI), and plasma leptin concentrations were measured, and all study subjects were investigated for the presence of diabetes mellitus. Drug treatment, health status, and smoking habits were registered.RESULTS: After adjustment for gender, BMI, smoking habits, age, and diabetes, hyperleptinemia was independently (p < .001) associated with clozapine treatment and with treatment with conventional antipsychotics (p < .005) within a multiple regression analysis. In separate multiple regression analyses, leptin levels were significantly associated with clozapine treatment in men (p = .002) and women (p =.023) and with conventional antipsychotic treatment in men (p = .027) but not in women.CONCLUSION: Treatment with clozapine as well as with conventional antipsychotics is associated with increased levels of circulating leptin. Hyperleptinemia can be an important link in the development of overweight and the insulin resistance syndrome in subjects receiving antipsychotic drugs, especially atypical agents like clozapine.
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| 2. |
- Ruchkin, Vladislav, et al.
(författare)
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Psychopathology and age at onset of conduct problems in juvenile delinquents.
- 2003
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Ingår i: Journal of Clinical Psychiatry. - 0160-6689 .- 1555-2101. ; 64:8, s. 913-20
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: This study aimed to assess psychopathology among incarcerated Russian juvenile delinquents in relation to the onset of conduct problems.METHOD: 358 male juvenile delinquents were interviewed from January to September 1999, using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version. Early behavior problems, current antisocial behavior, and psychopathology were also assessed through self-reports. The presence of conduct disorder (CD) and other diagnoses was determined according to DSM-IV criteria.RESULTS: 73.2% of the incarcerated youths met criteria for CD. 23.5% of the total sample reported at least 1 criterion for CD being present before the age of 10 years. All participants from this early-onset group fulfilled the criteria for CD. This group also had significantly higher rates of psychopathology, and particularly of externalizing behaviors, as compared with youths whose conduct problems began at or after the age of 10 years.CONCLUSION: Poor psychosocial adaptation and future prognosis in juvenile delinquents with early-onset conduct problems may be related to their greater degree of psychiatric disturbance compared with later-onset delinquent youths. Need for psychiatric treatment should be carefully considered in prevention and rehabilitation efforts for troubled youths.
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