| 1. |
- Flärdh, Klas, et al.
(författare)
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Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium.
- 2009
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Ingår i: Nature Reviews. Microbiology. - : Springer Science and Business Media LLC. - 1740-1534 .- 1740-1526. ; 7:1, s. 36-49
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Forskningsöversikt (refereegranskat)abstract
- During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation is closely integrated with fundamental growth and cell-cycle processes, as well as with truly complex multicellular behaviour that involves hormone-like extracellular signalling and coordination with an extraordinarily diverse secondary metabolism. Not only are the bacterial cytoskeleton and the machineries for cell-wall assembly, cell division and chromosome segregation reorganized during sporulation, but the developmental programme of these fascinating organisms also has many unusual elements, including the formation of a sporulating aerial mycelium and the production of a surfactant peptide and a hydrophobic sheath that allow cells to escape from the surface tension of the growth medium.
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| 2. |
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| 3. |
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| 4. |
- Martínez, José L., et al.
(författare)
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Predicting antibiotic resistance
- 2007
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Ingår i: Nature Reviews Microbiology. - : Springer Science and Business Media LLC. - 1740-1526 .- 1740-1534. ; 5:12, s. 958-965
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Forskningsöversikt (refereegranskat)abstract
- The treatment of bacterial infections is increasingly complicated because microorganisms can develop resistance to antimicrobial agents. This article discusses the information that is required to predict when antibiotic resistance is likely to emerge in a bacterial population. Indeed, the development of the conceptual and methodological tools required for this type of prediction represents an important goal for microbiological research. To this end, we propose the establishment of methodological guidelines that will allow researchers to predict the emergence of resistance to a new antibiotic before its clinical introduction.
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| 5. |
- Sandegren, Linus, et al.
(författare)
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Bacterial gene amplification : implications for the evolution of antibiotic resistance
- 2009
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Ingår i: Nature Reviews Microbiology. - : Springer Science and Business Media LLC. - 1740-1526 .- 1740-1534. ; 7:8, s. 578-588
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Forskningsöversikt (refereegranskat)abstract
- Recent data suggest that, in response to the presence of antibiotics, gene duplication and amplification (GDA) constitutes an important adaptive mechanism in bacteria. For example, resistance to sulphonamide, trimethoprim and beta-lactams can be conferred by increased gene dosage through GDA of antibiotic hydrolytic enzymes, target enzymes or efflux pumps. Furthermore, most types of antibiotic resistance mechanism are deleterious in the absence of antibiotics, and these fitness costs can be ameliorated by increased gene dosage of limiting functions. In this Review, we highlight the dynamic properties of gene amplifications and describe how they can facilitate adaptive evolution in response to toxic drugs.
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| 6. |
- Weidmann, M, et al.
(författare)
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Networking for BSL-3/4 laboratory scientist training
- 2009
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Ingår i: Nature reviews. Microbiology. - : Springer Science and Business Media LLC. - 1740-1534 .- 1740-1526. ; 7:10, s. 756-U82
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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