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- Dahlbäck, Björn, et al.
(författare)
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Apolipoprotein M: structure and function
- 2008
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Ingår i: Future Lipidology. - : Informa UK Limited. - 1746-0875. ; 3:5, s. 495-503
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Forskningsöversikt (refereegranskat)abstract
- Lipoproteins in blood play an important physiological role transporting cholesterol, lipids and lipid-soluble substances to the different organs of the body. Diseases such as atherosclerosis, cardiovascular disease and stroke are associated with defects in lipoprotein metabolism. For many years, intense research has focused on the role of cholesterol in development of atherosclerosis. Cholesterol is transported in both LDL and HDL; increased concentrations of LDL-C are associated with atherosclerosis, whereas high HDL-C is considered to be protective against development of atherosclerosis. Apolipoproteins Al and B are the major proteins of HDL and LDL, respectively. In HDL, a large number of additional proteins with important functions have been identified. A late addition to the list of HDL-associated proteins is apoM, the structure and function of which are the topic of this review.
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| 3. |
- Norlin, Maria
(författare)
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Regulation of cellular steroid levels with special focus on oxysterol and estrogen metabolism
- 2008
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Ingår i: Future Lipidology. - : Informa UK Limited. - 1746-0875. ; 3:3, s. 337-346
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Forskningsöversikt (refereegranskat)abstract
- Steroids play essential roles in a number of physiological systems. However, disturbed functions or abnormal levels of steroids can result in serious health problems. The cellular levels of steroids are regulated by enzymes and other factors that control the formation and elimination of these compounds. Recent findings on steroid action and metabolism have identified novel links between two groups of steroids, oxysterols and estrogens. A better understanding of cellular processes related to these steroids is of interest for developing future therapies in several conditions, including endocrine tumors and hyperlipidemia.
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