| 1. |
- Ambrosetti, Elena, et al.
(författare)
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A DNA-nanoassembly-based approach to map membrane protein nanoenvironments
- 2020
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Ingår i: Nature Nanotechnology. - Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics. - 1748-3387 .- 1748-3395. ; 120:3, s. 273A-274A
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Tidskriftsartikel (refereegranskat)abstract
- Most proteins at the plasma membrane are not uniformly distributed but localize to dynamic domains of nanoscale dimensions. To investigate their functional relevance, there is a need for methods that enable comprehensive analysis of the compositions and spatial organizations of membrane protein nanodomains in cell populations. Here we describe the development of a non-microscopy based method for ensemble analysis of membrane protein nanodomains. The method, termed NANOscale DEciphEring of membrane Protein nanodomains (NanoDeep), is based on the use of DNA nanoassemblies to translate membrane protein organization information into a DNA sequencing readout. Using NanoDeep, we characterised the nanoenvironments of Her2, a membrane receptor of critical relevance in cancer. Importantly, we were able to modulate by design the inventory of proteins analysed by NanoDeep. NanoDeep has the potential to provide new insights into the roles of the composition and spatial organization of protein nanoenvironments in the regulation of membrane protein function.
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| 2. |
- Andrén, Daniel, 1991, et al.
(författare)
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Microscopic metavehicles powered and steered by embedded optical metasurfaces
- 2021
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Ingår i: Nature Nanotechnology. - : Springer Science and Business Media LLC. - 1748-3387 .- 1748-3395. ; 16:9, s. 970-974
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Tidskriftsartikel (refereegranskat)abstract
- Nanostructured dielectric metasurfaces offer unprecedented opportunities to manipulate light by imprinting an arbitrary phase gradient on an impinging wavefront(1). This has resulted in the realization of a range of flat analogues to classical optical components, such as lenses, waveplates and axicons(2-6). However, the change in linear and angular optical momentum(7) associated with phase manipulation also results in previously unexploited forces and torques that act on the metasurface itself. Here we show that these optomechanical effects can be utilized to construct optical metavehicles-microscopic particles that can travel long distances under low-intensity plane-wave illumination while being steered by the polarization of the incident light. We demonstrate movement in complex patterns, self-correcting motion and an application as transport vehicles for microscopic cargoes, which include unicellular organisms. The abundance of possible optical metasurfaces attests to the prospect of developing a wide variety of metavehicles with specialized functional behaviours.
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| 3. |
- Chen, Shangzhi, et al.
(författare)
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Conductive polymer nanoantennas for dynamic organic plasmonics
- 2020
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Ingår i: Nature Nanotechnology. - London : Nature Publishing Group. - 1748-3387 .- 1748-3395. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Being able to dynamically shape light at the nanoscale is oneof the ultimate goals in nano-optics1. Resonant light–matterinteraction can be achieved using conventional plasmonicsbased on metal nanostructures, but their tunability is highlylimited due to a fixed permittivity2. Materials with switchablestates and methods for dynamic control of light–matterinteraction at the nanoscale are therefore desired. Here weshow that nanodisks of a conductive polymer can supportlocalized surface plasmon resonances in the near-infraredand function as dynamic nano-optical antennas, with their resonancebehaviour tunable by chemical redox reactions. Theseplasmons originate from the mobile polaronic charge carriersof a poly(3,4-ethylenedioxythiophene:sulfate) (PEDOT:Sulf)polymer network. We demonstrate complete and reversibleswitching of the optical response of the nanoantennasby chemical tuning of their redox state, which modulatesthe material permittivity between plasmonic and dielectricregimes via non-volatile changes in the mobile chargecarrier density. Further research may study different conductivepolymers and nanostructures and explore their usein various applications, such as dynamic meta-optics andreflective displays.
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| 4. |
- Cornelis, Geert
(författare)
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Key principles and operational practices for improved nanotechnology environmental exposure assessment
- 2020
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Ingår i: Nature Nanotechnology. - : Springer Science and Business Media LLC. - 1748-3387 .- 1748-3395. ; 15, s. 731-742
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Forskningsöversikt (refereegranskat)abstract
- Nanotechnology is identified as a key enabling technology due to its potential to contribute to economic growth and societal well-being across industrial sectors. Sustainable nanotechnology requires a scientifically based and proportionate risk governance structure to support innovation, including a robust framework for environmental risk assessment (ERA) that ideally builds on methods established for conventional chemicals to ensure alignment and avoid duplication. Exposure assessment developed as a tiered approach is equally beneficial to nano-specific ERA as for other classes of chemicals. Here we present the developing knowledge, practical considerations and key principles need to support exposure assessment for engineered nanomaterials for regulatory and research applications.The operationalization and improvement of environmental exposure assessment models for engineered nanomaterials can build on ten emerging principles relating to their release pathways, waste handling, transformations, influence of the properties on reactions and role that organisms can play in their fate and transport.
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| 5. |
- Engelsen, Nils Johan, 1987, et al.
(författare)
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Ultrahigh-quality-factor micro- and nanomechanical resonators using dissipation dilution
- 2024
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Ingår i: Nature Nanotechnology. - 1748-3387 .- 1748-3395. ; 19:6, s. 725-737
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Forskningsöversikt (refereegranskat)abstract
- Mechanical resonators are widely used in sensors, transducers and optomechanical systems, where mechanical dissipation sets the ultimate limit to performance. Over the past 15 years, the quality factors in strained mechanical resonators have increased by four orders of magnitude, surpassing the previous state of the art achieved in bulk crystalline resonators at room temperature and liquid helium temperatures. In this Review, we describe how these advances were made by leveraging ‘dissipation dilution’—where dissipation is reduced through a combination of static tensile strain and geometric nonlinearity in dynamic strain. We then review the state of the art in strained nanomechanical resonators and discuss the potential for even higher quality factors in crystalline materials. Finally, we detail current and future applications of dissipation-diluted mechanical resonators.
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| 6. |
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| 7. |
- Goswami, Sreetosh, et al.
(författare)
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Charge disproportionate molecular redox for discrete memristive and memcapacitive switching
- 2020
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Ingår i: Nature Nanotechnology. - : Springer Science and Business Media LLC. - 1748-3387 .- 1748-3395. ; 15:5, s. 380-389
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Tidskriftsartikel (refereegranskat)abstract
- Electronic symmetry breaking by charge disproportionation results in multifaceted changes in the electronic, magnetic and optical properties of a material, triggering ferroelectricity, metal/insulator transition and colossal magnetoresistance. Yet, charge disproportionation lacks technological relevance because it occurs only under specific physical conditions of high or low temperature or high pressure. Here we demonstrate a voltage-triggered charge disproportionation in thin molecular films of a metal-organic complex occurring in ambient conditions. This provides a technologically relevant molecular route for simultaneous realization of a ternary memristor and a binary memcapacitor, scalable down to a device area of 60 nm(2). Supported by mathematical modelling, our results establish that multiple memristive states can be functionally non-volatile, yet discrete-a combination perceived as theoretically prohibited. Our device could be used as a binary or ternary memristor, a binary memcapacitor or both concomitantly, and unlike the existing 'continuous state' memristors, its discrete states are optimal for high-density, ultra-low-energy digital computing. Charge disproportionation in thin molecular films of a metal-organic complex enables the realization of a ternary memristor and binary memcapacitor.
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| 8. |
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| 9. |
- Grommet, Angela Beth, 1991, et al.
(författare)
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Chemical Reactivity Under Nanoconfinement
- 2020
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Ingår i: Nature Nanotechnology. - : Springer Science and Business Media LLC. - 1748-3387 .- 1748-3395. ; 15:4, s. 256-271
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Forskningsöversikt (refereegranskat)
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| 10. |
- Hansen, Steffen Foss, et al.
(författare)
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Nanotechnology meets circular economy
- 2022
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Ingår i: Nature Nanotechnology. - : Springer Science and Business Media LLC. - 1748-3387 .- 1748-3395. ; 17:7, s. 682-685
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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