| 1. |
- Forsey, R.J., et al.
(författare)
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Plasma cytokine profiles in elderly humans
- 2003
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Ingår i: Mechanisms of Ageing and Development. - 0047-6374 .- 1872-6216. ; 124:4, s. 487-493
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- It is known that as we age, immune dysregulation often occurs, leading to failing health, and increased susceptibility to a number of different diseases. In this study we have investigated plasma cytokine profiles in order to identify immune markers of ageing. Plasma samples were obtained from 138 participants of the Swedish longitudinal NONA study (aged 86, 90 and 94 years) and 18 healthy Swedish volunteers (aged between 32 and 59 years). Our results show significantly increased levels of the pro-inflammatory cytokine interleukin-6 (P<0.0001) and soluble intercellular adhesion molecule-1 (P<0.0001) in the elderly group. The anti-inflammatory cytokine interleukin-10 did not alter with age whereas active (naturally processed) transforming growth factor-ß levels were significantly (P<0.0001) increased in the elderly group. No difference was observed between males and females. These data suggest that there are measurable changes in cytokine profiles with ageing with increased levels of potentially harmful molecules, which may contribute to immune alterations and declining health in the elderly population. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
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| 2. |
- Nilsson, Bengt-Olof, et al.
(författare)
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Morbidity does not influence the T-cell immune risk phenotype in the elderly : Findings in the Swedish NONA Immune Study using sample selection protocols
- 2003
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Ingår i: Mechanisms of Ageing and Development. - : Elesvier. - 0047-6374 .- 1872-6216. ; 124:4, s. 469-476
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Tidskriftsartikel (refereegranskat)abstract
- A critical issue in our understanding of ageing and the immune system refers to the health status of the population from which inferences are drawn. The commonly used SENIEUR protocol, selecting individuals representing 'normal ageing' has recently been under debate because a substantial amount of individuals with various health problems are excluded. The aim of the present study was to investigate the influence of morbidity on immune parameters and to evaluate the associations with the T-cell immune risk phenotype (IRP), related to cytomegalovirus (CMV) seropositivity by applying the SENIEUR protocol and the OCTO-Immune protocol in the unselected population based sample (n = 138) of oldest-olds, participating in the Swedish NONA Immune Study. The SENIEUR protocol excluded over 90% of the sample whereas the OCTO-Immune protocol excluded almost 65% of the sample. Three independent groups, very healthy (SENIEUR), moderately healthy (OCTO-Immune) and frail (non-SENIEUR/non-OCTO-Immune) were created. Flow cytometry studies on lymphocyte sub-populations revealed no significant difference in CD4/CD8 ratio, CD3+CD4-CD8+, CD3+CD4+CD8-, CD8+CD57+CD28-, CD8+CD56+CD57- or CD8+CD56+CD57+ between the very healthy, moderately healthy and the frail subsamples. Our findings indicate that morbidity does not significantly influence the T-cell immune risk profile in the elderly, and we suggest the inclusion of broader samples in future immunogerontological studies.
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| 6. |
- Pawelec, G, et al.
(författare)
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The SENIEUR protocol after 16 years.
- 2001
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Ingår i: Mechanisms of Ageing and Development. - 0047-6374 .- 1872-6216. ; 122:2, s. 132-134
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Vanmechelen, E, et al.
(författare)
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Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders
- 2001
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Ingår i: Mechanisms of Ageing and Development. - 0047-6374. ; 122:16, s. 2005-2011
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Tidskriftsartikel (refereegranskat)abstract
- The reliability of cerebrospinal fluid (CSF)-tau and CSF-beta-amyloid assays for diagnosis of Alzheimer's disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSF-tau levels can discriminate CJD from AD.
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