Sökning: L773:1872 8081 OR L773:0951 6433
> (2010-2014) >
Ligand binding by P...
Ligand binding by PDZ domains
-
- Chi, Celestine N. (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,ETH,Chi Celestine
-
Bach, Anders (författare)
-
Stromgaard, Kristian (författare)
-
visa fler...
-
Gianni, Stefano (författare)
-
- Jemth, Per (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
visa färre...
-
(creator_code:org_t)
- 2012-06-07
- 2012
- Engelska.
-
Ingår i: Biofactors. - : Wiley. - 0951-6433 .- 1872-8081. ; 38:5, s. 338-348
- Relaterad länk:
-
https://uu.diva-port... (primary) (Raw object)
-
visa fler...
-
http://uu.diva-porta...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common proteinprotein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found in most cell types, but neuronal proteins, for example, are particularly rich in these domains. The general function of PDZ domains is to bring proteins together within the appropriate cellular compartment, thereby facilitating scaffolding, signaling, and trafficking events. The many functions of PDZ domains under normal physiological as well as pathological conditions have been reviewed recently. In this review, we focus on the molecular details of how PDZ domains bind their protein ligands and their potential as drug targets in this context.
Nyckelord
- PDZ domain
- ligand binding
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas