| 1. |
- Räihä, Niels, et al.
(författare)
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Letters to the editor.
- 2004
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Ingår i: Journal of Pediatric Gastroenterology and Nutrition - Jpgn. - : Elsevier BV. - 1536-4801. ; 18:4, s. 453-453
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Toft, G, et al.
(författare)
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Epidemiological evidence on reproductive effects of persistent organochlorines in humans
- 2004
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Ingår i: Reproductive Toxicology. - : Elsevier BV. - 1873-1708 .- 0890-6238. ; 19:1, s. 5-26
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Forskningsöversikt (refereegranskat)abstract
- Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health. (C) 2004 Elsevier Inc. All rights reserved.
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| 3. |
- Källén, Bengt, et al.
(författare)
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Maternal drug use in early pregnancy and infant cardiovascular defect
- 2003
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Ingår i: Reproductive Toxicology. - 1873-1708. ; 17:3, s. 255-261
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the paper is to identify maternal drug use that may be associated with an increased risk for cardiac defects in the offspring. A case-control study was performed with cases (cardiovascular defects without known chromosome anomalies) being identified from three Swedish health registers (n = 5015) and controls being all infants born in Sweden during the period 1 July 1995-2001 (n = 577,730). Information on drug exposure was obtained by interview in early pregnancy. Associations between maternal drug use and infant cardiovascular defect were identified for insulin, antihypertensives, fertility drugs, erythromycin, naproxen, anticonvulsants, nitrofurantoin, clomipramine, and budesonide in nasal preparations. Some of these associations are probably due to confounding from underlying disease or complaint, some may be due to multiple testing, some may be true drug effects. Further studies are needed to verify or reject these associations. (C) 2003 Elsevier Science Inc. All rights reserved.
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| 4. |
- Källén, Bengt, et al.
(författare)
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Use of folic acid and delivery outcome: a prospective registry study
- 2002
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Ingår i: Reproductive Toxicology. - 1873-1708. ; 16:4, s. 327-332
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Tidskriftsartikel (refereegranskat)abstract
- Periconceptional use of folic acid is thought to reduce the risk for both neural tube defects and other congenital malformations. Most published data were obtained retrospectively. We used the Swedish Medical Birth Registry to study congenital malformations in infants born of women who reported the use of folic acid in early pregnancy (of which 70% probably used it also preconceptionally) and compared them with population rates. We divided the material according to two major confounders: subfertility problems and use of antiepileptic drugs. We found no protective effect of folic acid tablet use on the rate of congenital malformations but data on neural tube defects were scarce. Our results support the scepticism recently expressed in the literature on the beneficial effect of folic acid in preventing congenital malformations, especially of a non-neural tube defect type.
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| 5. |
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