| 1. |
- Karlsson, Martin, 1978, et al.
(författare)
-
Prophylactic Fibrinogen Infusion in Cardiac Surgery Patients: Effects on Biomarkers of Coagulation, Fibrinolysis, and Platelet Function.
- 2011
-
Ingår i: Clinical and applied thrombosis/hemostasis. - : SAGE Publications. - 1938-2723 .- 1076-0296. ; 17:4, s. 393-404
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: We have recently reported that prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass grafting (CABG) surgery. Because fibrinogen for the first time was administered to patients without hereditary fibrinogen deficiency or ongoing bleeding, a detailed analysis of the effects of fibrinogen concentrate on biomarkers of coagulation, fibrinolysis, and platelet function was performed. Methods: Twenty CABG patients with preoperative plasma fibrinogen levels <3.8 g/L were included in a prospective study. Patients were randomized to preoperative infusion of 2 g fibrinogen concentrate (fibrinogen group) or no infusion (control group). Activated partial thromboplastin time (aPTT), prothrombin time, activated clotting time, and plasma concentrations of fibrinogen, antithrombin, thrombin-antithrombin complex, prothrombin fragment 1.2, and d-dimer, thromboelastometry, platelet count, and platelet aggregometry were analyzed before and 15 minutes after infusion, and 2 and 24 hours after surgery. Results: Fifteen minutes after infusion of fibrinogen concentrate, fibrinogen plasma levels increased by 0.6 +/- 0.2 g/L (P < .001 between groups), and induced minimal changes in aPTT and plasma levels of antithrombin, while remaining variables remained unchanged. After surgery, fibrinogen levels no longer differed between groups. d-dimer was significantly higher after surgery in the fibrinogen group (P = .03), while none of the other markers were statistically different between groups. Conclusions: Infusion of 2 g fibrinogen to cardiac surgery patients, without hereditary or acquired fibrinogen deficiency or ongoing bleeding, results in no or minimal changes in biomarkers reflecting coagulation and platelet function. An increased release of fibrin degradation products was detected after surgery in fibrinogen-treated patients.
|
|
| 2. |
- Beckerman, Carina, 1956-
(författare)
-
Transforming and Computerizing Professional Artifacts : An Underestimated Opportunity for Learning
- 2010
-
Ingår i: International Journal of Healthcare Delivery Reform Initiative. - Philadelphia, US : IGI Publishing. - 1938-0216 .- 1938-0224. ; 2:3, s. -10
-
Tidskriftsartikel (refereegranskat)abstract
- Improving the artifacts a knowledge worker uses and how he or she exercises his or her knowledge is a desire that is part of being professional, especially since modern man are supposed to live in a knowledge society. In the knowledge society there is a continuous structuring and re-structuring, construction and re-construction and learning and re-learning going on due to implementing new information and communication technology. But many of these projects fail in spite of management spending huge amounts of money on them. This paper focuses on and wants to create an awareness of how an artefact such as a new knowledge management system becomes a driving force behind expanding the knowledge of an anesthesist and has implications for continuous learning among a group of employees at the anesthesia and intensive care unit. In addition to this, implementing new technology is an underestimated opportunity for learning. This paper suggests that a significant educational effort is taking place in society channelled through many these IT-projects, even when they fail.
|
|
| 3. |
- Aramo-Immonen, Heli, 1964-, et al.
(författare)
-
Multicultural Software Development : The Productivity Perspective
- 2011
-
Ingår i: International Journal of Information Technology Project Management. - : IGI Global. - 1938-0232 .- 1938-0240. ; 2:1, s. 19-36
-
Tidskriftsartikel (refereegranskat)abstract
- Productivity management is a challenge for software engineering companies and, in this regard, there is a current trend toward globalization. Via acquisitions and mergers, business has become international and employs different national cultures. Therefore, the focus of this article is on the understanding of cultural differences affecting productivity in globalized software production. The relation between productivity and non coding activities in software development projects has not been proven. Software development is expert work, typically made in closely collaborating local teams and global distribution of expert work increases the degree of difficulty. In this paper, the authors analyze multicultural ICT companies from their productivity perspective through the lens of cultural differences. The purpose of this study is to report findings based on general cultural studies and reported experiences that seem to affect productivity in the software industry. Some company cases are also described and analyzed.
|
|
| 4. |
- Gatenholm, Paul, 1956, et al.
(författare)
-
Bacterial Nanocellulose as a Renewable Material for Biomedical Applications
- 2010
-
Ingår i: MRS Bulletin. - : Springer Science and Business Media LLC. - 0883-7694 .- 1938-1425. ; 35:3, s. 208-213
-
Tidskriftsartikel (refereegranskat)abstract
- Nanocellulose, such as that produced by the bacteria Gluconacetobacter xylinus (bacterial cellulose, BC), is an emerging biomaterial with great potential as a biological implant, wound and burn dressing material, and scaffolds for tissue regeneration. BC has remarkable mechanical properties despite the fact that it contains up to 99% water. The water-holding ability is the most probable reason why BC implants do not elicit any foreign body reaction. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization and cell support. The architecture of BC materials can be engineered over length scales ranging from nano to macro by controlling the biofabrication process. This article describes current and future applications of BC in the biomedical field.
|
|
| 5. |
- Lilja Andersson, Petra, 1964-, et al.
(författare)
-
The transition from rookie to genuine nurse : narratives from Swedish nurses 1 year after graduation
- 2010
-
Ingår i: Journal of Continuing Education in Nursing. - : Slack Inc. - 0022-0124. ; 41:4, s. 186-192
-
Tidskriftsartikel (refereegranskat)abstract
- This article describes nurses' experiences during their first year after graduation, based on the qualitative content analysis of eight interviews. The results show that the nurses experienced a transition from "being a rookie," including being accepted as a member of the team and respected as a colleague, to "becoming a genuine nurse," including the feeling of being able to shoulder responsibility, prioritize tasks, and convey confidence to patients. This transition seems to occur regardless of support, and it is important to be aware of nurses' level of maturity and to adjust the degree of responsibility given to them because they may not be comfortable revealing their limitations to others. J Contin Educ Nurs 2010;41(4):186-192.
|
|
| 6. |
- Rasmussen Goloubeva, Irina, 1964-
(författare)
-
"Molly Bloom: A Re-Immersion in the Concrete"
- 2010
-
Ingår i: James Joyce Quarterly. - : Project Muse. - 0021-4183 .- 1938-6036. ; 47:3, s. 395-415
-
Tidskriftsartikel (refereegranskat)
|
|
| 7. |
- Aurelius, Johan, 1980, et al.
(författare)
-
Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes.
- 2013
-
Ingår i: Journal of leukocyte biology. - : Oxford University Press (OUP). - 1938-3673 .- 0741-5400. ; 93:1, s. 155-160
-
Tidskriftsartikel (refereegranskat)abstract
- NK cells and T cells are commonly dysfunctional in CML, and their status may determine the course of disease. We aimed to define the molecular mechanisms of leukemia-induced immunosuppression with focus on the role of ROS and the PARP-1 pathway of cell death. Malignant granulocytes from patients with BCR-ABL-positive CML expressed the oxygen radical-producing enzyme NOX, produced large amounts of ROS, and triggered extensive cell death in NK cells. Inhibition of PARP-1 maintained NK cell viability in cocultures with suppressive leukemic cells. Under conditions of oxidative stress, PARP-1 inhibition upheld the capacity of NK cells to kill myeloid leukemic cells, in addition to restoring the proliferation and cytokine production of NK cells and cytotoxic T cells. Our findings are suggestive of a novel pathway of relevance to immunosuppression in CML.
|
|
| 8. |
- Fjellström, Christina, et al.
(författare)
-
To Be a Good Food Provider : An Exploratory Study Among Spouses of Persons With Alzheimer's Disease
- 2010
-
Ingår i: American Journal of Alzheimer’s Disease and Other Dementia. - : Sage Publications. - 1533-3175 .- 1938-2731. ; 25:6, s. 521-526
-
Tidskriftsartikel (refereegranskat)abstract
- Large proportions of people with dementia live at home and need help from a relative. The aim of the current study was to examine how people living with persons with Alzheimer's disease (AD) perceived everyday life aspects of food choices, cooking, and food-related work. The analyses are based on focus group interviews including women and men acting as caregivers to people with AD and living in Sweden. The main results identified from the data, were how cohabitants to persons with AD struggle with either taking on a new role as a food provider or extending it, but also how they tried to cope as carer, which entailed food being an important part of the treatment of the disease. Those expressing greatest concern were those perceiving themselves as inexperienced food providers and carers, which in this study were all men.
|
|
| 9. |
|
|
| 10. |
|
|
