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Novel hepaci- and p...
Novel hepaci- and pegi-like viruses in native Australian wildlife and non-human primates
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- Porter, Ashleigh F. (författare)
- Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sch Med Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.
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- Pettersson, John, 1981- (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sch Med Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.,Zoonosis Sci Ctr
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- Chang, Wei-Shan (författare)
- Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sch Med Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.
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- Harvey, Erin (författare)
- Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sch Med Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.
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- Rose, Karrie (författare)
- Taronga Conservat Soc Australia, Australian Registry Wildlife Hlth, Mosman 2088, Australia.
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- Shi, Mang (författare)
- Sun Yat Sen Univ, Sch Med, Guangzhou, Peoples R China.
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- Eden, John-Sebastian (författare)
- Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sch Med Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Westmead Inst Med Res, Ctr Virus Res, Westmead, NSW 2145, Australia.
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- Buchmann, Jan (författare)
- Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sch Med Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.
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- Moritz, Craig (författare)
- Australian Natl Univ, Res Sch Biol Ctr Biodivers Anal, Acton, ACT, Australia.
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- Holmes, Edward C. (författare)
- Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sch Med Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.
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Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sch Med Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia. Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
- 2020-08-20
- 2020
- Engelska.
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Ingår i: Virus Evolution. - : OXFORD UNIV PRESS. - 2057-1577. ; 6:2
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The Flaviviridae family of positive-sense RNA viruses contains important pathogens of humans and other animals, including Zika virus, dengue virus, and hepatitis C virus. The Flaviviridae are currently divided into four genera-Hepacivirus, Pegivirus, Pestivirus, and Flavivirus-each with a diverse host range. Members of the genus Hepacivirus are associated with an array of animal species, including humans, non-human primates, other mammalian species, as well as birds and fish, while the closely related pegiviruses have been identified in a variety of mammalian taxa, also including humans. Using a combination of total RNA and whole-genome sequencing we identified four novel hepaci-like viruses and one novel variant of a known hepacivirus in five species of Australian wildlife. The hosts infected comprised native Australian marsupials and birds, as well as a native gecko (Gehyra lauta). From these data we identified a distinct marsupial clade of hepaci-like viruses that also included an engorged Ixodes holocyclus tick collected while feeding on Australian long-nosed bandicoots (Perameles nasuta). Distinct lineages of hepaci-like viruses associated with geckos and birds were also identified. By mining the SRA database we similarly identified three new hepaci-like viruses from avian and primate hosts, as well as two novel pegi-like viruses associated with primates. The phylogenetic history of the hepaci-and pegi-like viruses as a whole, combined with co-phylogenetic analysis, provided support for virus-host co-divergence over the course of vertebrate evolution, although with frequent cross-species virus transmission. Overall, our work highlights the diversity of the Hepacivirus and Pegivirus genera as well as the uncertain phylogenetic distinction between.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- hepacivirus
- pegivirus
- marsupial
- metagenomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Porter, Ashleigh ...
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Pettersson, John ...
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Chang, Wei-Shan
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Harvey, Erin
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Rose, Karrie
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Shi, Mang
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Eden, John-Sebas ...
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Buchmann, Jan
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Moritz, Craig
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Holmes, Edward C ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Mikrobiologi
- Artiklar i publikationen
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Virus Evolution
- Av lärosätet
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Uppsala universitet