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3D printed fluidic ...
3D printed fluidic swab for COVID-19 testing with improved diagnostic yield and user comfort
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- Kim, Joochan (författare)
- Sungkyunkwan Univ SKKU, South Korea
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- Jeon, Jaehyung (författare)
- Sungkyunkwan Univ SKKU, South Korea
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- Jang, Hyowon (författare)
- Korea Res Inst Biosci & Biotechnol KRIBB, South Korea
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- Moon, Youngkwang (författare)
- Sungkyunkwan Univ SKKU, South Korea
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- Abafogi, Abdurhaman Teyib (författare)
- Sungkyunkwan Univ SKKU, South Korea
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- van Noort, Danny (författare)
- Linköpings universitet,Biofysik och bioteknik,Tekniska fakulteten
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- Lee, Jinkee (författare)
- Sungkyunkwan Univ SKKU, South Korea; Sungkyunkwan Univ SKKU, South Korea
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- Kang, Taejoon (författare)
- Korea Res Inst Biosci & Biotechnol KRIBB, South Korea; Sungkyunkwan Univ SKKU, South Korea
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- Park, Sungsu (författare)
- Sungkyunkwan Univ SKKU, South Korea; Sungkyunkwan Univ SKKU, South Korea
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(creator_code:org_t)
- SPRINGER, 2023
- 2023
- Engelska.
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Ingår i: NANO CONVERGENCE. - : SPRINGER. - 2196-5404. ; 10:1
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The current standard method of diagnosing coronavirus disease 2019 (COVID-19) involves uncomfortable and invasive nasopharyngeal (NP) sampling using cotton swabs (CS), which can be unsuitable for self-testing. Although mid-turbinate sampling is an alternative, it has a lower diagnostic yield than NP sampling. Nasal wash (NW) has a similar diagnostic yield to NP sampling, but is cumbersome to perform. In this study, we introduce a 3D printed fluidic swab (3DPFS) that enables easy NW sampling for COVID-19 testing with improved diagnostic yield. The 3DPFS comprises a swab head, microchannel, and socket that can be connected to a syringe containing 250 & mu;L of NW solution. The 3DPFS efficiently collects nasal fluid from the surface of the nasal cavity, resulting in higher sensitivity than CS for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This was confirmed by both reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and lateral flow assays (LFA) in virus-spiked nasal samples and clinical samples. Additionally, users reported greater comfort when using the 3DPFS compared to CS. These findings suggest that the 3DPFS can improve the performance of COVID-19 testing by facilitating efficient and less painful nasal sample collection.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- COVID-19; SARS-CoV-2; Mid-turbinate; Fluidic swab; 3D printing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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