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Reactive oxygen spe...
Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention
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- Nasi, A (författare)
- Ultimovacs AB, Uppsala, Sweden
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- McArdle, S (författare)
- Nottingham Trent University, Nottingham, UK
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- Gaudernack, G (författare)
- Ultimovacs ASA, Oslo, Norway
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- Westman, Gabriel, 1977- (författare)
- Uppsala universitet,Infektionsmedicin
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- Melief, C (författare)
- Leiden University Medical Center, The Netherlands; ISA Pharmaceuticals, Leiden, The Netherlands
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- Rockberg, Johan (författare)
- KTH,Proteinteknologi,Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden
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- Arens, R (författare)
- Leiden University Medical Center, Leiden, The Netherlands
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- Kouretas, D (författare)
- Dept Biochemistry-Biotechnology, University of Thessaly, Larissa, Greece
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- Sjölin, Jan (författare)
- Uppsala universitet,Infektionsmedicin
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- Mangsbo, Sara, 1981- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Ultimovacs AB, Uppsala Sweden,Immunonkologi
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(creator_code:org_t)
- Elsevier Inc. 2020
- 2020
- Engelska.
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Ingår i: Toxicology reports. - : Elsevier Inc.. - 2214-7500. ; 7, s. 768-771
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- During the current COVID-19 pandemic, a need for evaluation of already available drugs for treatment of the disease is crucial. Hereby, based on literature review from the current pandemic and previous outbreaks with corona viruses we analyze the impact of the virus infection on cell stress responses and redox balance. High levels of mortality are noticed in elderly individuals infected with SARS-CoV2 and during the previous SARS-CoV1 outbreak. Elderly individuals maintain a chronic low level of inflammation which is associated with oxidative stress and inflammatory cytokine production, a condition that increases the severity of viral infections in this population. Coronavirus infections can lead to alterations of redox balance in infected cells through modulation of NAD + biosynthesis, PARP function along with altering proteasome and mitochondrial function in the cell thereby leading to enhanced cell stress responses which further exacerbate inflammation. ROS production can increase IL-6 production and lipid peroxidation resulting in cell damage. Therefore, early treatment with anti-oxidants such as NAC during COVID-19 can be a way to bypass the excessive inflammation and cell damage that lead to severe infection, thus early NAC as intervention should be evaluated in a clinical trial setting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Antioxidants
- Article
- C reactive protein
- COVID-19
- N-acetylcysteine
- Oxidative stress
- SARS-CoV2
- Severe acute respiratory syndrome coronavirus 2
- acetylcysteine
- aging
- angiotensin converting enzyme 2
- cell stress
- coronavirus disease 2019
- cryopyrin
- cytokine production
- cytokine release
- group 2d secretory phospholipase a2
- homeostasis
- human
- immune response
- inflammasome
- innate immunity
- interferon
- interleukin 6
- mortality
- neutrophil cytosol factor 1
- nicotinamide adenine dinucleotide adenosine diphos
- nonhuman
- oxidation reduction reaction
- oxidative phosphorylation
- peptides and proteins
- priority journal
- proteasome
- protein expression
- reactive oxygen metabolite
- reduced nicotinamide adenine dinucleotide phosphat
- toll like receptor 4
- tryptophan 2
- 3 dioxygenase
- tumor necrosis factor
- unclassified drug
- viremia
- Biology with specialization in Molecular Immunology
- Infektionssjukdomar
- Immunologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Nasi, A
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McArdle, S
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Gaudernack, G
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Westman, Gabriel ...
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Melief, C
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Rockberg, Johan
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Arens, R
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Kouretas, D
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Sjölin, Jan
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Mangsbo, Sara, 1 ...
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