SwePub - sökning: L773:2296 2360

Numrering	Referens	Omslagsbild	Hitta
1.	Evans, Brittany, 1982-, et al. (författare) Blunted Heart Rate Response as a Potential Endophenotype of Substance Use Disorders : Evidence from High-Risk Youth 2015 Ingår i: Frontiers in Pediatrics. - : Frontiers Media S.A.. - 2296-2360. ; 3 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Children of parents with a substance use disorder (CPSUD) are at increased risk for developing problematic substance use later in life. Endophenotypes may help to clarify the mechanism behind this increased risk. However, substance use and externalizing symptoms may confound the relation between dysregulated physiological stress responding and familial risk for substance use disorders (SUDs).METHODS: We examined whether heart rate (HR) responses differed between CPSUDs and controls. Participants (aged 11-20 years) were CPSUDs (N = 75) and controls (N = 363), semi-matched on the basis of sex, socioeconomic status, and ethnicity. HR was measured continuously during a psychosocial stress procedure. Substance use and externalizing symptoms were self-reported and mother-reported, respectively.RESULTS: A piecewise, mixed-effects model was fit for HR across the stress procedure, with fixed effects for HR reactivity and HR recovery. CPSUDs showed a blunted HR recovery. CPSUDs reported drinking more frequently, were more likely to use tobacco daily, were more likely to report ever use of cannabis and used cannabis more frequently, and exhibited more externalizing symptoms. These variables did not confound the relation between familial risk for SUDs and a blunted HR recovery.CONCLUSION: Our findings suggest dysregulated autonomic nervous system (ANS) responding in CPSUDs and contribute to the accumulating evidence for ANS dysregulation as a potential endophenotype for SUDs.
2.	Zandian, M, et al. (författare) Control of Body Weight by Eating Behavior in Children 2015 Ingår i: Frontiers in pediatrics. - : Frontiers Media SA. - 2296-2360. ; 3, s. 89- Tidskriftsartikel (refereegranskat)

Evans, Brittany, 1982-, et al. (författare)
Blunted Heart Rate Response as a Potential Endophenotype of Substance Use Disorders : Evidence from High-Risk Youth
2015
Ingår i: Frontiers in Pediatrics. - : Frontiers Media S.A.. - 2296-2360. ; 3
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Children of parents with a substance use disorder (CPSUD) are at increased risk for developing problematic substance use later in life. Endophenotypes may help to clarify the mechanism behind this increased risk. However, substance use and externalizing symptoms may confound the relation between dysregulated physiological stress responding and familial risk for substance use disorders (SUDs).METHODS: We examined whether heart rate (HR) responses differed between CPSUDs and controls. Participants (aged 11-20 years) were CPSUDs (N = 75) and controls (N = 363), semi-matched on the basis of sex, socioeconomic status, and ethnicity. HR was measured continuously during a psychosocial stress procedure. Substance use and externalizing symptoms were self-reported and mother-reported, respectively.RESULTS: A piecewise, mixed-effects model was fit for HR across the stress procedure, with fixed effects for HR reactivity and HR recovery. CPSUDs showed a blunted HR recovery. CPSUDs reported drinking more frequently, were more likely to use tobacco daily, were more likely to report ever use of cannabis and used cannabis more frequently, and exhibited more externalizing symptoms. These variables did not confound the relation between familial risk for SUDs and a blunted HR recovery.CONCLUSION: Our findings suggest dysregulated autonomic nervous system (ANS) responding in CPSUDs and contribute to the accumulating evidence for ANS dysregulation as a potential endophenotype for SUDs.

Träfflista för sökning "L773:2296 2360 srt2:(2015)"

Avgränsa träffmängd